Designs for Health Twice Daily Multi | Full Guide

Name: Twice Daily Multi™
Brand: Designs For Health
SKU: DH-TDM120
Price: 62.49 USD
Availability: InStock

In-depth guide to Designs for Health Twice Daily Multi™ — methylated B vitamins, chelate minerals, and science-based nutrient forms for energy and metabolism.

Product Overview

What is the Designs for Health Twice Daily Multi?

Twice Daily Multi™ is a comprehensive multivitamin formulated to deliver optimal amounts of nutrients that are difficult to obtain from diet alone. Rather than relying on generic vitamin forms, this formula features higher-quality ingredients — including methylated B12 and folate, Vitamin E isomers as DeltaGold® tocotrienols, and true amino acid chelate minerals — designed for superior tolerance and absorption.

The formula is built around three interconnected goals: methylation support, energy production, and metabolic function. Each nutrient form was selected based on current nutritional science to create a multivitamin that goes beyond basic coverage. It is Non-GMO and free of gluten, dairy, soy, and iron.

The deliberate omission of iron allows the formula to focus on the nutrients most commonly under-supplied by modern diets, making it suitable for both men and women who obtain adequate iron through food or a separate supplement.

How It Works

Superior nutrient forms for methylation, energy, and metabolism

A distinguishing feature of this multivitamin is the use of active, methylated B vitamins. The formula provides 680 mcg of Quatrefolic® methylfolate (5-MTHF) — a form of folate that has demonstrated high bioavailability and long-lasting stability — alongside methylcobalamin (active B12) and pyridoxal-5-phosphate (active B6). These nutrients directly support the methylation cycle, which is essential for homocysteine metabolism, DNA synthesis, neurotransmitter production, and detoxification.

Research suggests that methylated B vitamins may be particularly important for individuals with common MTHFR gene variants who cannot efficiently convert standard folic acid into its active form. By supplying 5-MTHF directly, the formula bypasses this enzymatic step.

The B-vitamin complex — thiamin, riboflavin, niacin, B6, folate, B12, biotin, and pantothenic acid — collectively serves as cofactors for hundreds of enzymatic reactions involved in energy-yielding metabolism, mitochondrial function, and macronutrient processing. The Vitamin E is provided as DeltaGold® delta and gamma tocotrienols rather than standard alpha-tocopherol, and minerals including Zinc, Selenium, Manganese, and Chromium are supplied as amino acid chelates or glycinate complexes for optimal absorption.

What's inside

Key ingredients

Vitamin A (from palmitate, mixed carotenoids) — 960 mcg

Vitamin A is a group of fat-soluble compounds essential for vision, immune function, epithelial integrity, and gene regulation. It is provided here as both preformed retinol (palmitate) and provitamin A carotenoids. Studies suggest Vitamin A supports the visual cycle through its metabolite 11-cis-retinal, promotes healthy immune cell differentiation, and is involved in gene transcription via retinoic acid receptors. Research confirms it plays a role in hematopoiesis and the maintenance of skin and mucosal barriers.

Vitamin C (as ascorbic acid) — 500 mg

Vitamin C is a water-soluble antioxidant and enzymatic cofactor essential for collagen biosynthesis, L-carnitine production, and iron absorption. Research suggests it supports normal energy-yielding metabolism by facilitating carnitine biosynthesis (required for mitochondrial fatty acid transport) and enhancing non-heme iron uptake. Studies indicate Vitamin C contributes to immune defense by supporting epithelial barrier function, enhancing phagocytosis, and promoting lymphocyte proliferation. It also helps regenerate Vitamin E, extending antioxidant protection.

Vitamin D (as cholecalciferol) — 25 mcg

Vitamin D3 (cholecalciferol) is a fat-soluble prohormone that supports calcium absorption, bone mineralization, immune modulation, and muscle function. Research suggests that Vitamin D deficiency is strongly associated with fatigue, muscle weakness, and reduced energy, and correction of deficiency has been shown in clinical trials to significantly improve fatigue outcomes. Studies also link low Vitamin D status with components of metabolic syndrome including insulin resistance and dyslipidemia, with supplementation modestly improving select parameters in deficient individuals.

Vitamin K (as K1 phytonadione, vitamin K2 menaquinone-4, and MenaQ7 Full Spectrum MK-6, MK-7, MK-9) — 120 mcg

This formula provides a comprehensive Vitamin K complex spanning both K1 and multiple K2 menaquinone forms. Vitamin K is essential for the gamma-carboxylation of proteins involved in blood coagulation, bone metabolism, and cardiovascular health. Research suggests that carboxylated osteocalcin and matrix Gla protein (both Vitamin K-dependent) help direct calcium into bones while reducing arterial calcification. MK-7 displays superior bioavailability and a markedly extended half-life compared to phylloquinone.

Thiamin (vitamin B-1) (as thiamin HCl) — 2.3 mg

Thiamin is an essential cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase — key enzymes coupling glycolysis to the TCA cycle for mitochondrial ATP production. Research confirms it plays a critical role in carbohydrate metabolism, nervous system function, and energy-yielding metabolism. Deficiency causes profound cellular energy failure and neurological dysfunction.

Riboflavin (vitamin B-2) — 2.8 mg

Riboflavin is the precursor to FAD and FMN, coenzymes essential for the mitochondrial electron transport chain, beta-oxidation of fatty acids, and TCA cycle function. FAD directly accepts electrons at Complex II of the ETC, making riboflavin indispensable for cellular ATP production. As a cofactor for MTHFR, riboflavin also supports the methylation cycle — research shows that riboflavin status is inversely related to homocysteine levels, particularly in individuals with the MTHFR 677TT genotype.

Niacin (as niacinamide and niacin) — 50 mg

Niacin (vitamin B3) is the dietary precursor to NAD+ and NADP+, coenzymes that drive over 500 enzymatic reactions including glycolysis, the TCA cycle, and oxidative phosphorylation. Research suggests supplementation can raise cellular NAD concentrations and support mitochondrial energy production. Provided here as a blend of niacinamide and niacin to support both metabolic function and tolerability.

Vitamin B-6 (as pyridoxal-5-phosphate) — 5.2 mg

Supplied as pyridoxal-5-phosphate (PLP), the biologically active form that serves as a cofactor for over 140 enzyme reactions. PLP is essential for neurotransmitter synthesis (serotonin, dopamine, GABA, norepinephrine), amino acid metabolism, glycogen mobilization, and hemoglobin formation. Research confirms its role in the transsulfuration pathway, where it enables the conversion of homocysteine to cystathionine — supporting methylation cycle clearance.

Folate (as Quatrefolic [6S]-5-methyltetrahydrofolate, glucosamine salt) — 680 mcg

Quatrefolic® provides the bioactive (6S)-5-methyltetrahydrofolate form of folate, which demonstrated high bioavailability and solubility as well as long-lasting stability. Unlike synthetic folic acid, 5-MTHF bypasses the need for enzymatic conversion by MTHFR and does not produce unmetabolized folic acid in plasma. Research suggests this is particularly relevant for individuals with MTHFR polymorphisms. Clinical trials demonstrate that 5-MTHF effectively reduces homocysteine and supports the methylation cycle, neurotransmitter synthesis, and red blood cell production.

Vitamin B-12 (as methylcobalamin) — 500 mcg

Methylcobalamin is the metabolically active form of B12 that serves as a cofactor for methionine synthase — the enzyme that remethylates homocysteine to methionine, directly sustaining the SAMe/methylation cycle. Research confirms B12 is essential for DNA synthesis, myelin formation, neurological function, and red blood cell production. Deficiency causes megaloblastic anemia and severe fatigue; correction consistently restores energy and neurological function.

Biotin (as d-biotin) — 30 mcg

Biotin is a cofactor for five carboxylase enzymes that catalyze critical steps in the metabolism of fatty acids, glucose, and amino acids — including pyruvate carboxylase (TCA cycle anaplerosis), propionyl-CoA carboxylase, and acetyl-CoA carboxylase. Research confirms these enzymes are essential for energy homeostasis and macronutrient utilization.

Pantothenic acid (as D-calcium pantothenate) — 12 mcg

Pantothenic acid is the essential precursor to coenzyme A (CoA), which is required for the TCA cycle (via acetyl-CoA), fatty acid beta-oxidation, and the synthesis of steroid hormones and neurotransmitters. Research confirms that without adequate CoA, cellular energy metabolism from carbohydrates, fats, and amino acids cannot proceed. It also supports normal mental performance and the reduction of tiredness and fatigue.

Iodine (as Potassium iodide) — 150 mcg

Iodine is an essential trace element required for the synthesis of thyroid hormones, which regulate metabolic rate, energy production, and numerous developmental processes. Potassium iodide provides a well-absorbed form of iodine at the standard recommended daily amount.

Zinc (as Zinc bisglycinate chelate) — 15 mg

Zinc is an essential trace element required as a cofactor for over 300 enzymes spanning all six enzyme classes. Supplied as Zinc bisglycinate chelate — a true amino acid chelate form — for optimal tolerance and absorption. Research suggests Zinc supports immune regulation, DNA synthesis, insulin signaling, and cognitive function. It also participates in DNA methylation through its structural role in DNA methyltransferases and BHMT.

Selenium (as Selenium glycinate complex) — 200 mcg

Selenium is incorporated into 25 human selenoproteins — including glutathione peroxidases, thioredoxin reductases, and iodothyronine deiodinases — that protect against oxidative stress and regulate thyroid hormone metabolism. Research suggests Selenium supports mitochondrial health through mitochondrial thioredoxin reductase and glutathione peroxidase, which protect the electron transport chain from oxidative damage.

Manganese (as TRAACS Manganese Bisglycinate Chelate) — 1 mg

Manganese is an essential trace mineral required for Manganese superoxide dismutase (MnSOD) — the primary antioxidant enzyme within mitochondria — as well as glycosyltransferases for bone and cartilage formation, pyruvate carboxylase for gluconeogenesis, and arginase for the urea cycle. Supplied as TRAACS® bisglycinate chelate for enhanced bioavailability.

Chromium (as TRAACS Chromium nicotinate glycinate chelate) — 200 mcg

Chromium is a trace mineral studied for its proposed role in enhancing insulin signaling via a low-molecular-weight Chromium-binding substance (chromodulin). Systematic reviews and meta-analyses of randomized controlled trials suggest that Chromium supplementation may support glycemic parameters, particularly in individuals with type 2 diabetes or impaired glucose metabolism. Supplied as TRAACS® nicotinate glycinate chelate.

Molybdenum (as TRAACS Molybdenum Glycinate Chelate) — 100 mcg

Molybdenum is an essential trace element that functions solely through the Molybdenum cofactor (Moco), which is required by four human enzymes: sulfite oxidase (sulfur amino acid metabolism), xanthine oxidase (purine catabolism), aldehyde oxidase, and mitochondrial amidoxime-reducing component (mARC). Research confirms sulfite oxidase is critical — its deficiency leads to severe neurological symptoms. Supplied as TRAACS® glycinate chelate.

Vitamin E isomers (as DeltaGold® delta and gamma tocotrienols) — 15 mg

Rather than standard alpha-tocopherol, this formula provides DeltaGold® delta and gamma tocotrienols — naturally occurring Vitamin E isomers with potent antioxidant activity. Tocotrienols have three unsaturated bonds in their phytyl tail, allowing greater membrane mobility and higher antioxidant efficiency. Research suggests they protect mitochondrial membranes from lipid peroxidation and may support metabolic parameters in individuals with dyslipidemia.

Boron (as boroorganic glycine) — 2 mg

Boron is a trace mineral that research suggests may influence calcium, magnesium, and Vitamin D metabolism, potentially supporting bone health. Studies in postmenopausal women found that 3 mg/day of Boron reduced urinary calcium excretion and influenced steroid hormone levels. Limited evidence also suggests Boron may facilitate insulin action through effects on thyroid hormone conversion.

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Twice Daily Multi™

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Twice Daily Multi™

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Who Benefits

Who is the Designs for Health Twice Daily Multi for?

This multivitamin is designed for adults who want a science-based daily multi with superior nutrient forms. It may be particularly relevant for:

Individuals with MTHFR gene variants — The active methylfolate (Quatrefolic®) and methylcobalamin bypass the need for enzymatic conversion, supporting efficient methylation regardless of genetic variation.
Adults seeking comprehensive energy support — The full B-vitamin complex, provided in active coenzyme forms, supports mitochondrial ATP production and energy-yielding metabolism across multiple pathways.
Those focused on metabolic health — Chromium, Zinc, Vitamin D, and the B vitamins collectively support glucose metabolism, insulin signaling, and macronutrient processing.
People with dietary gaps — The formula is specifically crafted to contain optimal amounts of nutrients not easily obtained from most diets.

This product is vegetarian, Non-GMO, and free of gluten, dairy, and soy, making it compatible with a wide range of dietary preferences.

Usage Guide

How to take Twice Daily Multi™

Take 2 capsules per day with meals or as directed by your health-care practitioner.

Each bottle contains 120 capsules, providing a 60-day supply at the recommended serving size of 2 capsules daily.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What makes Designs for Health Twice Daily Multi different from other multivitamins?

This formula uses higher-quality ingredient forms than most multivitamins, including methylated B12 (methylcobalamin) and folate (Quatrefolic® 5-MTHF), Vitamin E isomers as DeltaGold® tocotrienols, and true amino acid chelate minerals for optimal tolerance and absorption. These exceptional ingredients are combined in an up-to-date, science-based formulation.

Why does this multivitamin contain methylfolate instead of folic acid?

The formula provides 680 mcg of Quatrefolic® methylfolate (5-MTHF), which is the biologically active form of folate. Unlike synthetic folic acid, 5-MTHF does not require enzymatic conversion by MTHFR and has demonstrated high bioavailability and solubility as well as long-lasting stability. This may be particularly beneficial for individuals with MTHFR gene variants who cannot efficiently convert folic acid.

Why is there no iron in this multivitamin?

This women's and men's multivitamin was formulated without iron to focus on creating a formula that contains optimal amounts of the most important nutrients that are not easily obtained in most diets. Individuals who need supplemental iron can take it separately as directed by a health-care practitioner.

Is this multivitamin suitable for vegetarians?

Yes. Twice Daily Multi™ is vegetarian, Non-GMO, and free of gluten, dairy, and soy.

What type of Vitamin E is used in this formula?

Rather than standard alpha-tocopherol, this formula uses DeltaGold® delta and gamma tocotrienols — a highly bioavailable form of Vitamin E with potent antioxidant activity. Tocotrienols differ structurally from tocopherols and research suggests they offer distinct biological benefits.

How many capsules should I take per day?

The recommended serving is 2 capsules per day taken with meals, or as directed by your health-care practitioner. Each bottle contains 120 capsules, providing a 60-day supply.

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