GI Revive Designs for Health | Complete Gut Support

Name: GI Revive®
Brand: Designs For Health
SKU: DH-GIR225
Price: 89.49 USD
Availability: InStock

Discover how GI Revive Designs for Health supports leaky gut, IBS, and digestive health with 15 targeted ingredients including L-glutamine, Zinc, and botanicals.

Comprehensive GI Support

GI Revive Designs for Health: Advanced Gastrointestinal Repair

GI Revive® by Designs for Health is a 15-in-1 gut support powder formulated with specific amino acids, a botanical blend, and minerals to offer comprehensive support for gastrointestinal (GI) health and function. The lining of the GI tract must be permeable enough for nutritional absorption yet also provide a barrier against toxins, allergens, and certain microbes.

The ingredients in GI Revive® support healthy intestinal function by coating and soothing the GI lining and promoting the body's natural GI repair process. This formula also supports GI tract health, a healthy inflammatory response, and healthy intestinal function and regularity.

Available in a convenient powdered form with a natural peach flavor and sweetened with Stevia leaf extract, GI Revive® can be mixed into any beverage or functional food powder. It contains no GMOs, dairy, gluten, or soy.

How It Works

A Multi-Pathway Approach to Gut Lining Support

GI Revive® addresses gastrointestinal health through multiple complementary mechanisms. The formula contains a robust 1,500 mg of L-glutamine, an amino acid that provides structural and metabolic support for intestinal cells. L-glutamine is the primary fuel for enterocytes — the cells lining the intestinal wall — and research suggests it plays a critical role in maintaining tight junction integrity and mucosal barrier function.

MSM powder supports the structure, integrity, and permeability of the GI cell walls and a healthy inflammatory response. Meanwhile, a botanical blend of deglycyrrhizinated Licorice root extract, Aloe vera, Marshmallow root, Okra extract, and Cat's claw provides support for healthy intestinal function by coating and soothing the intestinal lining. These ingredients promote the body's natural gastrointestinal repair process.

Zinc (as Zinc-L-Carnosine) plays a crucial role in maintaining the integrity of the gastric mucosa, while N-Acetyl-D-Glucosamine serves as a critical structural component of the intestinal mucus layer. Together, these ingredients work synergistically to support mucosal defense, barrier integrity, and gut-associated immune function.

What's inside

Key ingredients

L-glutamine (1.5 g)

L-glutamine is the most abundant amino acid in the body and the primary fuel source for intestinal enterocytes. Research suggests it plays a key role in maintaining mucosal barrier integrity and tight junction function. A landmark RCT found that 79.6% of IBS-D patients receiving L-glutamine achieved significant symptom reduction versus 5.8% on placebo. A 2024 systematic review and meta-analysis of randomized placebo-controlled trials found that doses above 30 g/day significantly reduced intestinal permeability markers. Studies also suggest L-glutamine may support gastric mucosal integrity, modulate gut microbiota composition by reducing the Firmicutes-to-Bacteroidetes ratio, and help reduce abdominal discomfort through improved intestinal barrier function.

Zinc (as Zinc-L-Carnosine) (17 mg)

Zinc is an essential trace mineral that plays a crucial role in maintaining the integrity of the gastric mucosa and exerts a gastroprotective action against gastric lesions. The chelated form Zinc L-carnosine has been specifically shown in human crossover RCTs to help prevent increases in small intestinal permeability by stabilizing tight junctions and increasing epithelial resistance. A 2025 patient-based clinical study showed that orally administered Zinc induced tight junctional remodeling and reduced passive transmucosal permeability. Zinc carnosine has also demonstrated in clinical trials the ability to support the gastric mucosal lining, and research suggests it may help inhibit H. pylori.

N-Acetyl-D-Glucosamine (1 g)

N-Acetyl-D-Glucosamine (NAG) is the primary precursor for glycosaminoglycans (GAGs), structural compounds that give the intestinal mucus layer its thickness, viscosity, and barrier-forming properties. It is preferentially taken up by intestinal epithelial cells and redirected toward Mucin and GAG synthesis. In a clinical trial with 34 IBD patients, NAG at 6 g daily for four weeks improved symptoms including pain, diarrhea, and bleeding in 88% of cases. NAG also supports the intestinal mucosal barrier and selectively promotes beneficial gut bacteria including Bifidobacterium species, and post-treatment biopsies have shown reduced inflammatory infiltration and restoration of mucosal villi.

Citrus pectin (1 g)

Citrus pectin is a fermentable soluble dietary fiber recognized for its prebiotic properties and potential to support digestive health. An RCT in 87 diarrhea-predominant IBS patients found that daily pectin significantly reduced symptoms, improved stool consistency, and enhanced quality of life versus placebo. Research suggests it acts as a prebiotic, selectively increasing Bifidobacterium, Lactobacillus, and Akkermansia muciniphila while reducing potentially pathogenic bacteria. Citrus pectin can also help relieve constipation by promoting colonic water retention and increasing stool bulk, and infant clinical trials suggest it may support intestinal permeability in inflamed states.

Deglycyrrhizinated Licorice root Extract (400 mg)

Licorice root (Glycyrrhiza glabra) has been used in traditional medicine for gastrointestinal problems for over 4,000 years. Deglycyrrhizinated licorice (DGL) has been studied in clinical trials for gastritis and peptic ulcer disease, where research suggests it enhances gastric mucus production, promotes mucosal healing, and may exhibit anti-H. pylori activity. A placebo-controlled RCT of a standardized Glycyrrhiza extract showed significant reduction in heartburn and regurgitation. DGL is also a component of Iberogast (STW-5), for which multiple RCTs demonstrate support for reducing abdominal discomfort and IBS symptoms. In traditional Chinese medicine, licorice appears in approximately 60% of prescriptions.

Aloe vera Extract (300 mg)

Aloe vera has been used as a traditional medicine for over 2,000 years across Arab, Chinese, Egyptian, Greek, Indian, and other cultures. A 2015 pilot RCT compared Aloe vera gel syrup to omeprazole and ranitidine over 4 weeks, finding it reduced all eight assessed GERD symptoms with no adverse events requiring withdrawal. A 2021 review of five clinical studies concluded Aloe vera gel syrup consistently reduced GERD symptoms. Research suggests its polysaccharides, particularly acemannan, support gut-barrier repair, stimulate Mucin secretion, and exert anti-inflammatory effects on the intestinal lining. A 2025 umbrella review confirmed Aloe vera improved IBS symptoms alongside peppermint oil and soluble fiber.

Slippery elm bark (200 mg)

Slippery elm (Ulmus rubra) has been used in Native American traditional medicine for centuries for gastrointestinal and skin disorders. Its inner bark contains mucilaginous polysaccharides that form a viscous gel when mixed with water, coating and soothing the GI lining. A 2010 published pilot study using two slippery elm-containing formulas in 31 IBS patients found significant improvements in bowel movement frequency, stool consistency, abdominal pain, bloating, and global symptom severity. The FDA classifies slippery elm as an oral demulcent. Its polysaccharides also have documented prebiotic potential, supporting Lactobacillus and Bifidobacterium species.

Mucin (200 mg)

Mucin glycoproteins form the structural backbone of the mucus layer that covers all mucosal surfaces in the GI tract. They provide a physical, chemical, and immunological barrier between the environment and the organism. Mucin glycans meet the formal definition of a prebiotic — serving as selective nutritional substrates for specific gut bacteria. In vitro and preclinical research suggests Mucin supplementation may reshape microbial composition, enriching beneficial Lactobacillus species and promoting polyamine production that supports epithelial barrier function. Clinical studies in xerostomia confirm Mucin-based preparations effectively support mucosal lubrication.

Marshmallow Root (100 mg)

Marshmallow (Althaea officinalis) has been used in traditional European medicine for over 2,000 years. Its root contains mucilage that can make up as much as 35% of the dry weight, forming a soft, slippery gel on contact with water that coats mucosal surfaces. The German Commission E approved Marshmallow root for mild inflammation of the gastric mucosa, and ESCOP lists indications including irritation of the gastric mucosa and dry irritating cough. In vitro studies demonstrate that Marshmallow root polysaccharides stimulate cell physiology of human epithelial cells. Aqueous root extract also inhibits hyaluronidase activity, which may contribute to its anti-inflammatory and tissue-protective effects.

Chamomile Extract (100 mg)

Chamomile (Matricaria chamomilla) is one of the oldest and most widely used medicinal plants, employed for gastrointestinal complaints for millennia. The German Commission E approves Chamomile for gastrointestinal spasms and inflammatory conditions of the GI tract. Its key constituent apigenin has documented antispasmodic effects on intestinal smooth muscle. Chamomile is a core ingredient in Iberogast (STW-5), the most clinically studied herbal GI formula, with high-quality RCT evidence for reducing IBS symptoms and abdominal pain. Relaxant effects have been detected on human jejunum preparations, providing scientific support for its traditional use in spasmodic gastrointestinal disorders.

Okra Extract (100 mg)

Okra (Abelmoschus esculentus) is a medicinal plant widely used in Turkish traditional medicine for ulcers and gastritis. Its mucilage is a highly viscous polysaccharide that coats and soothes the GI lining. Animal studies demonstrate significant gastroprotective effects — research suggests Okra (500 mg/kg) inhibited ulcer formation by 81%, comparable to the drug famotidine. Studies also indicate that anti-adhesive compounds in Okra may help prevent H. pylori adhesion to gastric mucosa. Okra's pectin and mucilage polysaccharides function as prebiotics, supporting beneficial colonic bacteria and stimulating short-chain fatty acid production.

Cat's claw (100 mg)

Cat's claw (Uncaria tomentosa) is a tropical vine used in South American traditional medicine for over 2,000 years, particularly by the Asháninka people for gastric ulcers, intestinal disorders, and inflammation. It is included in Brazil's National List of Essential Medicines. Research suggests its pentacyclic oxindole alkaloids suppress chronic inflammation through inhibition of NF-κB activation and TNF-α. Preclinical studies confirm anti-inflammatory and gastroprotective effects in gastric models. Traditionally, Cat's claw has been used for gastritis, dysentery, and colitis, and it is listed as a traditional remedy for leaky bowel syndrome in multiple herbal medicine references.

Methylsulfonylmethane / MSM (100 mg)

MSM is a naturally occurring organosulfur compound known for its potential anti-inflammatory effects, particularly through the inhibition of transcription factors such as NF-κB. Research suggests it may help reduce production of pro-inflammatory cytokines including IL-1, IL-6, and TNF-α. MSM supports the structure, integrity, and permeability of the GI cell walls and a healthy inflammatory response. The FDA labeled MSM as Generally Recognized As Safe in 2008, and preclinical and clinical studies report good tolerability at doses up to 4 grams daily.

Quercetin (100 mg)

Quercetin is a flavonol polyphenol found widely in fruits, vegetables, and tea, with documented anti-inflammatory and antioxidant properties. Research suggests it supports intestinal barrier function by promoting assembly of tight junction proteins ZO-2, occludin, and claudin-1. In vitro studies in Caco-2 cell monolayers confirmed increased transepithelial electrical resistance and reduced paracellular permeability. Quercetin also stabilizes mast cells, reducing histamine-driven barrier disruption, and modulates gut microbiota composition through probiotic-like promotion of beneficial bacterial species.

Prune Powder (100 mg)

Prunes (dried plums, Prunus domestica) are among the best-studied natural foods for digestive health. Their combination of sorbitol, pectin, and polyphenols promotes colonic water retention, accelerates gut transit, and normalizes stool consistency. In head-to-head clinical trials, prunes outperformed psyllium on stool frequency and consistency scores. A 12-month RCT found Prune supplementation significantly enriched Lachnospiraceae — bacteria associated with reduced inflammatory markers and gut barrier integrity. Prune fiber and polyphenols also support Bifidobacterium populations in healthy adults.

Organic Stevia Leaf

Organic Stevia leaf (Stevia rebaudiana Bertoni) serves as the natural, zero-calorie sweetener in this formula. Stevia has been used for centuries by the Guaraní peoples of South America as a sweet herb and digestive tonic. Steviol glycosides do not induce a glycemic response when ingested. The European Food Safety Authority and the FDA have evaluated high-purity steviol glycosides and determined them to be safe for consumption.

Decaffeinated Black tea

Black tea (Camellia sinensis) polyphenols, particularly theaflavins and thearubigins, selectively modulate the composition of gut microbiota, promoting beneficial bacterial species such as Flavonifractor plautii and supporting Bifidobacterium and Lactobacillus populations. In traditional Chinese, Indian, and European medicine, Black tea's astringent tannins were widely used as a folk remedy for digestive upset. In its decaffeinated form, it contributes polyphenolic benefits without the stimulant effects of caffeine.

Designs For Health

GI Revive®

✓ Free shipping over $75
✓ 90-day easy returns
✓ Ships within hours

GI Revive®

$89.49

Who Benefits

Who May Benefit from GI Revive®

GI Revive® is formulated for individuals seeking comprehensive support for gastrointestinal health. It may be particularly relevant for those experiencing concerns related to leaky gut, digestive system irregularities, or IBS-related discomfort.

The formula's blend of amino acids, botanical extracts, and minerals addresses multiple aspects of gut health simultaneously — from mucosal coating and soothing to barrier integrity and gut-associated immune support. This makes it suitable for individuals who want a broad-spectrum approach to GI wellness rather than targeting a single mechanism.

Because it is free of GMOs, dairy, gluten, and soy, GI Revive® accommodates a range of dietary preferences and sensitivities.

Usage Guidelines

How to Take GI Revive®

Mix 8 grams (approx. one scoop) in water or other liquid per day, or as directed by your health care practitioner.

Each container provides 28 servings. The powder features a natural peach flavor sweetened with Stevia leaf extract, making it easy to incorporate into a daily routine.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What makes GI Revive Designs for Health different from single-ingredient gut supplements?

GI Revive® is a 15-in-1 formula that combines specific amino acids (L-glutamine), minerals (Zinc as Zinc-L-Carnosine), and a comprehensive botanical blend (deglycyrrhizinated Licorice root extract, Aloe vera, Marshmallow root, Okra extract, Cat's claw, and others) to offer multi-pathway support for GI health. Rather than targeting a single mechanism, it supports the gut lining through coating, soothing, barrier integrity, and the body's natural GI repair processes.

Does GI Revive® contain any common allergens?

GI Revive® contains no GMOs, dairy, gluten, or soy. Individuals with specific allergies or sensitivities should review the full ingredient label and consult their health care practitioner.

How does L-glutamine in GI Revive® support gut health?

L-glutamine at 1,500 mg per serving provides structural and metabolic support for intestinal cells. It is the primary fuel source for enterocytes — the cells lining the intestinal wall. Research suggests L-glutamine supports tight junction integrity, mucosal barrier function, and may help modulate gut microbiota composition. Clinical trials have investigated its role in IBS and intestinal permeability.

What role does Zinc-L-Carnosine play in this formula?

Zinc-L-Carnosine provides 17 mg of Zinc in a chelated form specifically shown in human studies to support intestinal tight junction stability and gastric mucosal integrity. This form of Zinc has demonstrated in clinical trials the ability to support the gastric mucosal lining, and research suggests it may help stabilize tight junctions and increase epithelial resistance in the small intestine.

Can GI Revive® be taken alongside other supplements or foods?

GI Revive® is a convenient powder that can be mixed into water or other liquid. For specific guidance on combining it with other supplements or dietary protocols, consult your health care practitioner, as some ingredients (such as deglycyrrhizinated licorice and Marshmallow root) may affect the timing of absorption of other substances.

How long does one container of GI Revive® last?

Each container provides 28 servings at the suggested serving size of one scoop (approximately 8 grams) per day.

Talk to an expert

Talk to Dr. Shannyn Fowl

Not sure if this is right for you? Book a free, no-pressure consultation for personalized guidance on your health goals.

Book your free consult →

Who we are

About Vitabase

A family-run reseller of premium supplements — free shipping, a 90-day guarantee, and real people who know the products.

Learn more about us →