Integrative Therapeutics Active B Complex Guide

Name: Active B-Complex
Brand: Integrative Therapeutics
SKU: IT-10032
Price: 18.25 USD
Availability: InStock

Comprehensive guide to Integrative Therapeutics Active B-Complex: all 8 B vitamins in active forms for energy, methylation, and nervous system support.

Overview

What Is Integrative Therapeutics Active B Complex?

Integrative Therapeutics Active B-Complex is a comprehensive blend of all eight essential B vitamins, including the active forms of B2, B6, B12, and folate, designed to support energy production and overall wellness.* It contains active forms of B2 (riboflavin-5'-phosphate), B6 (pyridoxal-5-phosphate), and B12 (methylcobalamin), as well as Quatrefolic® methylfolate for immediate bioavailability.

This formula supports daily energy, neurotransmitter production, and nerve function, promoting brain and nervous system health.* It also includes an excellent source of Choline to support healthy brain function. Active B-Complex helps maintain optimal cellular function, growth, and metabolism, making it a well-rounded choice for overall vitality and well-being.*

The formula is gluten-free and vegan, and free from wheat, soy, dairy, artificial colors, and flavors. Each bottle contains 60 capsules with a serving size of 1 capsule.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Why It Matters

Energy, Methylation, and Nervous System Support

B vitamins play essential roles in cell function, growth, and energy production. They support energy production by helping metabolize carbohydrates, proteins, and fats — converting food into fuel to help you tackle the day. Research confirms that each B vitamin serves as a cofactor or precursor in key metabolic pathways, from the TCA cycle and mitochondrial ATP production to neurotransmitter synthesis.

The nervous system relies heavily on B vitamins for the synthesis of serotonin, dopamine, and GABA — neurotransmitters closely linked to mood, focus, and cognitive function. Studies suggest that adequate B-vitamin status supports normal neurotransmitter balance and nervous system integrity.

Methylation is a fundamental biochemical process that influences DNA synthesis, homocysteine metabolism, and cellular repair. Active B-Complex provides active forms of folate (as Quatrefolic® methylfolate), B12 (as methylcobalamin), and riboflavin (as riboflavin-5'-phosphate), which research identifies as key participants in the methylation cycle. These active forms are readily utilized by the body without requiring additional enzymatic conversion.

What's inside

Key Ingredients

Thiamin (Vitamin B1) — 50 mg

Thiamin is an essential cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase — key enzymes that couple glycolysis to the TCA cycle and enable mitochondrial ATP production from glucose. Research confirms that thiamin plays a critical role in energy-yielding metabolism, and European regulatory authorities have authorized a health claim that B1 contributes to normal energy-yielding metabolism. Thiamin is also essential for neurological function, serving as a cofactor in glucose metabolism that indirectly supports synthesis of neurotransmitters, myelin, and nucleic acids in the nervous system. It is directly required for the synthesis of acetylcholine and modulates GABA and glutamate levels. Deficiency causes severe neurological disorders including peripheral neuropathy and Wernicke's encephalopathy.

Riboflavin (Vitamin B2) — 50 mg

Riboflavin is the precursor to FAD and FMN — coenzymes essential for the mitochondrial electron transport chain, beta-oxidation of fatty acids, and TCA cycle function. FAD directly accepts electrons at Complex II of the electron transport chain, making B2 indispensable for cellular ATP production. EFSA has authorized a health claim for riboflavin contributing to energy-yielding metabolism and reduction of tiredness and fatigue. Riboflavin is also the obligate coenzyme (as FAD) for MTHFR, the enzyme that converts 5,10-methyleneTHF to 5-MTHF — a critical step in the methylation cycle. Research demonstrates that riboflavin deficiency impairs MTHFR activity, reduces 5-MTHF levels, and elevates homocysteine, especially in individuals with the MTHFR 677TT genotype. Riboflavin transporter deficiency causes severe progressive neuropathy responsive to high-dose riboflavin supplementation, and FAD-dependent enzymes are indispensable for neuronal energy metabolism.

Niacin (Vitamin B3) — 100 mg

Niacin is the dietary precursor to NAD+ and NADP+ — coenzymes essential for over 500 enzymatic reactions including glycolysis, the TCA cycle, and oxidative phosphorylation. EFSA authorizes a health claim that niacin contributes to normal energy-yielding metabolism. NAD+ is also critical for neuronal energy metabolism, DNA repair, and survival of neurons. Severe deficiency causes pellagra with neurological manifestations including confusion and dementia. Niacin spares tryptophan from the kynurenine pathway, preserving its availability for serotonin synthesis, and is a precursor to NAD+ supporting energy metabolism in neurotransmitter-producing neurons.

Vitamin B6 (as Pyridoxal-5-Phosphate) — 50 mg

Vitamin B6, provided here in its active form pyridoxal-5-phosphate (PLP), is a cofactor for over 100 enzymatic reactions including amino acid metabolism, glycogen phosphorylase (crucial for muscle glycogen mobilization), and neurotransmitter biosynthesis. PLP is the essential coenzyme for decarboxylation reactions producing serotonin (from 5-HTP), dopamine (from L-DOPA), and GABA (from glutamate). Without PLP, all three pathways are impaired. EFSA authorizes the health claim that B6 contributes to normal energy-yielding metabolism and to the reduction of tiredness and fatigue. B6 also supports methylation by enabling the transsulfuration pathway — the CBS-catalyzed conversion of homocysteine to cystathionine — which clears homocysteine from the methylation cycle and supports methionine production for SAMe synthesis.

Folate (as Quatrefolic® Methylfolate) — 800 mcg

Folate is an indispensable cofactor in one-carbon metabolism, directly supporting the biosynthesis of purines, thymidylate, and S-adenosylmethionine (SAMe) — processes critical for DNA replication, repair, and cellular proliferation. Active B-Complex provides folate as Quatrefolic® methylfolate, a form that is immediately bioavailable without requiring enzymatic conversion by MTHFR. Research confirms folate is among the most extensively studied methylation-supporting nutrients, facilitating transport of methyl groups in the one-carbon pathway for DNA methylation and homocysteine remethylation. Deficiency produces global hypomethylation and impaired SAMe synthesis. Folate is also essential for nervous system development and maintenance, and deficiency is associated with peripheral neuropathy, depression, and cognitive decline. EFSA recognizes that folate contributes to normal energy-yielding metabolism and to the reduction of tiredness and fatigue.

Vitamin B12 (as Methylcobalamin) — 1000 mcg

Vitamin B12, provided as methylcobalamin — one of the two metabolically active forms — is essential for methionine synthase, which remethylates homocysteine to methionine using 5-MTHF, directly sustaining the SAMe/methylation cycle. B12 deficiency stalls this reaction, trapping folate in the methyl-folate trap and elevating homocysteine. B12 is also critically required for myelin synthesis, DNA synthesis, and fatty acid metabolism in nerve cells; its deficiency is one of the most common and clinically recognized reversible causes of peripheral neuropathy. Research confirms that B12 deficiency causes megaloblastic anemia and severe fatigue; correction of deficiency consistently restores energy. EFSA authorizes the health claim that B12 contributes to normal energy-yielding metabolism.

Biotin (Vitamin B7) — 300 mcg

Biotin is an essential coenzyme for five carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid catabolism — all central to energy homeostasis. EFSA authorizes the health claim that biotin contributes to normal energy-yielding metabolism. Biotin is also a cofactor for mitochondrial carboxylase enzymes including pyruvate carboxylase (TCA cycle anaplerosis) and propionyl-CoA carboxylase (branched-chain amino acid and odd-chain fatty acid catabolism), both localized in the mitochondrial matrix and essential for mitochondrial metabolic flux. Deficiency impairs energy metabolism and causes fatigue.

Pantothenic Acid (Vitamin B5) — 100 mg

Pantothenic acid is the essential precursor to coenzyme A (CoA), which is required for the metabolism of carbohydrates, fats, and proteins into ATP. CoA plays an indispensable role in the TCA cycle via acetyl-CoA and is essential for fatty acid beta-oxidation. EFSA authorizes the health claim that pantothenic acid contributes to normal energy-yielding metabolism and reduction of tiredness and fatigue. B5 is also essential for the synthesis of acetylcholine, the primary neurotransmitter enabling nervous system communication. EU health claims recognize its contribution to normal mental performance. Experimental B5 deficiency in humans produces neurological symptoms including paresthesia, muscle weakness, and impaired coordination.

Choline — 120 mg

Choline is an essential nutrient and a direct precursor to the neurotransmitter acetylcholine, which is critical for memory, attention, and mental alertness. Choline insufficiency impairs cognitive performance, and research supports its role in cholinergic neurotransmission. Choline is also the metabolic precursor to betaine (trimethylglycine), which donates methyl groups to homocysteine via BHMT, supporting SAMe regeneration — a key step in the methylation cycle. Higher dietary Choline intake is associated with lower circulating homocysteine concentrations. Choline is required for the synthesis of phosphatidylcholine, which enables hepatic VLDL secretion and proper liver function.

Ascorbyl palmitate

Ascorbyl palmitate is a lipophilic derivative of ascorbic acid (vitamin C) and palmitic acid. It serves as an antioxidant in the formula, helping to protect fat-soluble compounds from oxidative degradation. Research has demonstrated its ability to regenerate alpha-tocopherol (vitamin E) after oxidation by free radicals, and its amphipathic structure allows it to position at lipid membrane interfaces. The presence of Ascorbyl palmitate in oral supplements contributes to the ascorbic acid content and may help protect fat-soluble antioxidants within the formulation.

Integrative Therapeutics

Active B-Complex

✓ Free shipping over $75
✓ 90-day easy returns
✓ Ships within hours

Active B-Complex

$18.25

Who Benefits

Who Is Active B-Complex For?

Integrative Therapeutics Active B-Complex may be a good fit for adults seeking comprehensive B-vitamin support for everyday energy, methylation, and nervous system health. Because it provides active (coenzyme) forms of B2, B6, B12, and folate, it may be particularly relevant for individuals who want forms that are readily utilized by the body without requiring additional enzymatic conversion.

People concerned about maintaining healthy homocysteine levels may benefit from the combination of methylfolate, methylcobalamin, pyridoxal-5-phosphate, and riboflavin-5'-phosphate, which research suggests work together to support normal homocysteine metabolism through both remethylation and transsulfuration pathways.

Those experiencing occasional fatigue may appreciate the high-potency blend of B vitamins that support energy-yielding metabolism. The formula is also suitable for individuals following vegan diets or those who avoid gluten, wheat, soy, and dairy.

Directions

How to Take Active B-Complex

Adults take 1 or 2 capsules daily, preferably with food, or as recommended by a healthcare professional. If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What makes the B vitamins in Active B-Complex 'active'?

Active B-Complex contains the active (coenzyme) forms of key B vitamins: riboflavin-5'-phosphate (active B2), pyridoxal-5-phosphate (active B6), methylcobalamin (active B12), and Quatrefolic® methylfolate (active folate). These forms are readily utilized by the body without requiring additional enzymatic conversion, which may be especially relevant for individuals with certain genetic variations like MTHFR polymorphisms.

Does Active B-Complex support methylation?

Yes. The formula includes methylcobalamin, Quatrefolic® methylfolate, pyridoxal-5-phosphate, and riboflavin-5'-phosphate — nutrients that research identifies as key participants in the methylation cycle. Methylcobalamin serves as a cofactor for methionine synthase, which remethylates homocysteine to methionine. Methylfolate donates the methyl group for this reaction. Riboflavin (as FAD) is the obligate coenzyme for MTHFR, and B6 supports the transsulfuration pathway that clears homocysteine.

How does Active B-Complex support energy?

B vitamins are essential cofactors in the metabolic pathways that convert carbohydrates, proteins, and fats into cellular energy (ATP). Thiamin, riboflavin, and niacin are directly involved in the TCA cycle and mitochondrial electron transport chain. Pantothenic acid is the precursor to coenzyme A, required for acetyl-CoA production. Vitamin B6 supports glycogen mobilization and amino acid metabolism. European regulatory authorities have authorized health claims for multiple B vitamins contributing to normal energy-yielding metabolism and reduction of tiredness and fatigue.

Is Active B-Complex suitable for vegans?

Yes. Active B-Complex is vegan and also gluten-free, with no wheat, soy, dairy, artificial colors, or flavors. Since Vitamin B12 is not naturally present in plant foods, a vegan-friendly B12 supplement like methylcobalamin may be particularly beneficial for those following plant-based diets.

Why does Active B-Complex include Choline?

Choline is an essential nutrient that serves as a direct precursor to acetylcholine, a neurotransmitter critical for memory, attention, and mental alertness. It also functions as a methyl donor when converted to betaine, supporting homocysteine metabolism and the methylation cycle. Most people in the United States consume less than the Adequate Intake for Choline, making supplemental Choline a valuable addition to a B-complex formula.

How many capsules are in a bottle and what is the serving size?

Each bottle contains 60 capsules. The serving size is 1 capsule, and the recommended intake is 1 or 2 capsules daily, preferably with food, or as recommended by a healthcare professional.

Talk to an expert

Talk to Dr. Shannyn Fowl

Not sure if this is right for you? Book a free, no-pressure consultation for personalized guidance on your health goals.

Book your free consult →

Who we are

About Vitabase

A family-run reseller of premium supplements — free shipping, a 90-day guarantee, and real people who know the products.

Learn more about us →