Tri-Magnesium Integrative Therapeutics | Full Guide

Tri-Magnesium from Integrative Therapeutics delivers 300 mg of elemental Magnesium per capsule, designed to support cellular metabolism.* What sets this formula apart is its use of three complementary Magnesium forms — citrate, oxide, and malate — combined in a single capsule to provide broad-spectrum nutritional support for muscles, bones, and cardiovascular function.*

Magnesium is the fourth most abundant cation in the human body and a critical cofactor in over 300 enzymatic reactions that regulate energy metabolism, neuromuscular function, cardiovascular health, and bone integrity. Despite its essential nature, an estimated 56–68% of Americans do not obtain enough Magnesium from their daily diet to meet the recommended dietary allowance. Tri-Magnesium addresses this widespread shortfall with a thoughtfully designed multi-form blend.

The formula is gluten-free and vegan, with no wheat, corn, soy, dairy, artificial colors, or flavors. Each bottle contains 90 capsules.

Different forms of Magnesium vary in solubility, bioavailability, and concentration. Tri-Magnesium Integrative Therapeutics strategically combines three forms to leverage the strengths of each:

• Magnesium citrate — one of the most bioavailable forms, with high solubility in water (55%) and efficient absorption, substantially more soluble than Magnesium oxide across all states of acid secretion.
• Magnesium oxide — the most concentrated form by weight, delivering more elemental Magnesium per milligram of compound, though it has lower bioavailability compared to organic salts.
• Magnesium malate — an organic form in which Magnesium is chelated to malic acid, an organic molecule. Organic Magnesium forms are generally more soluble and have higher bioavailability than inorganic salts.

By pairing a highly bioavailable organic salt (citrate) and another well-absorbed organic form (malate) with a high-concentration inorganic salt (oxide), the formula aims to balance absorption efficiency with a robust per-capsule Magnesium yield.

Magnesium is indispensable for ATP synthesis — the fundamental energy currency of every cell. It plays a pivotal role in transition state formation during ATP synthesis and is an essential cofactor for the Na,K-ATPase pump that drives ion transport across cell membranes. These mechanisms underpin Tri-Magnesium's support for cellular metabolism, energy production, and overall physiological function.*

Tri-Magnesium Integrative Therapeutics is formulated for adults seeking comprehensive Magnesium support for bone density, muscle function, and cardiovascular health.* Several populations may find it particularly relevant:

• Adults concerned about bone health: Magnesium is involved in bone formation, influencing osteoblast and osteoclast activity, and affects concentrations of parathyroid hormone and active vitamin D. People with higher levels of Magnesium may have higher bone mineral density, which is important for helping reduce the risk of bone fractures.*
• Individuals experiencing muscle cramps or tension: Magnesium deficiency impairs muscle relaxation — muscles contract normally but may struggle to fully release when levels are low. Research suggests supplementation may support muscle recovery and reduce soreness in physically active individuals.*
• Those seeking cardiovascular support: Magnesium modulates cardiac ion channels, myocardial conduction, and contraction. Hypomagnesemia is directly linked to arrhythmias and increased cardiovascular risk.*
• People under stress: Tri-Magnesium supports a healthy response to stress, a positive outlook, and a sense of calm.* Magnesium may help replenish stress-depleted levels.*
• Older adults: Magnesium absorption and retention decrease with age. Older adults are more susceptible to Magnesium deficiency due to decreased absorption from food, increased medication use (certain diuretics can deplete Magnesium), and potential dietary restrictions.

Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for Magnesium. The RDA for adult men is 400–420 mg/day, while for adult women it is 310–320 mg/day. Each capsule of Tri-Magnesium provides 300 mg of elemental Magnesium, making it a convenient way to help bridge this common dietary gap.*

Adults take 1 capsule once or twice daily, or as recommended by a healthcare professional.

Each capsule delivers a full 300 mg of elemental Magnesium. At the one-capsule-daily serving, this provides roughly 71–97% of the adult RDA (depending on sex); at two capsules daily, total intake from the supplement reaches 600 mg of elemental Magnesium.

Important safety considerations: Magnesium supplements may interact with certain medications. If you take bisphosphonates (used for osteoporosis), separate dosing by at least 2 hours. Tetracycline or quinolone antibiotics should be taken at least 2 hours before or 4–6 hours after Magnesium. Magnesium may also reduce the absorption of gabapentin. Loop and thiazide diuretics can deplete Magnesium, while proton pump inhibitors (PPIs) taken for prolonged periods may cause low Magnesium levels. Consult a healthcare professional before use if you take any medications.