Vascanox HP®

Vascanox HP is a practitioner-formulated nitric oxide support supplement produced by Calroy Health Sciences and distributed through Designs for Health. It is designed for adults seeking sustained cardiovascular support, particularly those focused on maintaining healthy blood pressure already within the normal range, healthy circulation, and endothelial function. The product is appropriate for individuals who want a research-backed, multi-pathway approach to nitric oxide optimization, including those using it alongside Arterosil HP as part of a broader vascular health protocol.

The formula is built around Noxa24®, Calroy's patented proprietary blend of fermented black garlic extract, beetroot extract, and a panel of berry extracts — black currant, bilberry, raspberry, blue honeysuckle berry, and blueberry. These ingredients were selected for their complementary roles: beetroot and potassium nitrate supply dietary nitrates that feed the nitrate-nitrite-NO conversion pathway, while the fermented black garlic and berry polyphenols support endothelial nitric oxide synthase (eNOS) activity and help protect NO from oxidative degradation. The vitamin and mineral component is equally considered — vitamin C is delivered as magnesium and zinc ascorbate, thiamine is included at a meaningful clinical dose, and B12 is provided as methylcobalamin, the bioactive form. Each of these cofactors plays a role in supporting the enzymatic machinery of NO production and overall vascular health.

Nitric oxide functions as a signaling molecule within the vascular endothelium, triggering smooth muscle relaxation and vasodilation. This mechanism underlies its central role in blood pressure regulation and blood flow. The body produces NO through two primary pathways: the enzymatic NOS pathway, which relies on adequate substrate and cofactor availability, and the nitrate-nitrite-NO pathway, which is diet-dependent. Both pathways decline with age and are further impaired by oxidative stress, dietary inadequacy, and reduced endothelial glycocalyx integrity. Most nitric oxide supplements address only one of these pathways. Vascanox HP is designed to support both simultaneously, and in a published open-label IRB-approved clinical study, a single dose raised salivary nitric oxide levels for up to 24 hours — a meaningful distinction from single-pathway formulations that typically provide only a few hours of support.

Secondary benefits include support for antioxidant status through the berry polyphenol blend, and energy and cognitive clarity through the B-vitamin and thiamine content. The product is free from gluten, dairy, soy, eggs, fish, shellfish, tree nuts, peanuts, sesame, and other common allergens, and is vegan and non-GMO. Vascanox HP is a reasonable consideration for adults experiencing age-related cardiovascular changes, those with occupational or athletic demands on circulation, or individuals working with a practitioner on a foundational vascular health program.