Chromium (as amino acid chelate) — 67.00 mcg
Chromium is a trace mineral required for the formation of glucose tolerance factor (GTF), which potentiates insulin action. Research suggests Chromium supplementation may support glycemic control: a 2020 meta-analysis of 28 studies showed Chromium supplementation significantly reduced fasting plasma glucose, insulin, HbA1c, and HOMA-IR in diabetic patients. A 2022 meta-analysis found significant HbA1c reduction. A systematic review and meta-analysis of 20 RCTs with 1,147 cases found significant reductions in HOMA-IR in patients with T2DM, prediabetes, and confirmed insulin resistance. Chromium is also an essential trace mineral that supports pancreatic function by enhancing insulin receptor sensitivity.
Biotin — 300.00 mcg
Biotin (vitamin B7) is a water-soluble vitamin that acts as an essential cofactor in cellular metabolic processes including gluconeogenesis and fatty acid metabolism. A 2022 systematic review and meta-analysis of five RCTs involving 445 participants suggested that biotin supplementation for 28 to 90 days may help decrease fasting blood glucose. Biotin assists enzymes in breaking down fats, carbohydrates, and proteins — all critical processes in glucose metabolism. It also plays key roles in gene regulation and cell signaling that influence metabolic health.
Magnesium (as Magnesium oxide) — 125.00 mg
Magnesium is an essential mineral involved in over 300 enzymatic reactions, including glucose metabolism and insulin signaling. Multiple systematic reviews and meta-analyses of RCTs confirm that Magnesium supplementation significantly reduces fasting blood glucose and modestly improves HbA1c in type 2 diabetes patients, particularly those with low baseline Magnesium levels. Research also shows a significant effect on HOMA-IR, a key measure of insulin resistance. Magnesium is required for normal pancreatic β-cell function and insulin secretion, and supplementation for more than 4 months shows the most consistent improvements in insulin sensitivity.
Zinc (as Zinc oxide) — 7.50 mg
Zinc is involved in virtually all aspects of insulin metabolism, including insulin synthesis, secretion, and utilization. Meta-analyses show Zinc supplementation may improve glycemic parameters in type 2 diabetes. Zinc is essential for insulin storage, secretion, and signal transduction at the insulin receptor. Multiple clinical trials and meta-analyses confirm Zinc supplementation may reduce fasting blood glucose, HbA1c, and HOMA-IR. Zinc is found in the highest concentrations in pancreatic beta cells, where it is indispensable for insulin hexamer formation and beta cell signaling.
Vitamin C (ascorbic acid) — 50.00 mg
Vitamin C is a potent water-soluble antioxidant and cofactor for many enzymes involved in biological functions such as immune system support, collagen biosynthesis, and iron absorption. Studies have examined Vitamin C both as monotherapy and in antioxidant combinations for pancreatitis. Multiple RCTs of combined antioxidants including ascorbic acid showed pain reduction in chronic pancreatitis. As an antioxidant, Vitamin C helps protect tissues — including the pancreas — from oxidative stress.
Vitamin E (as tocopheryl succinate) — 15 IU
Vitamin E is a fat-soluble antioxidant that protects cell membranes from lipid peroxidation. Multiple RCTs and meta-analyses have examined Vitamin E's effect on glycemic indices in diabetic patients. A 2023 meta-analysis of 38 RCTs found significant reductions in HbA1c, fasting insulin, and HOMA-IR, though fasting blood glucose reduction was not statistically significant. Vitamin E has also been evaluated in combination antioxidant regimens for chronic pancreatitis pain management, with multiple placebo-controlled RCTs showing significant pain benefits.
Manganese (as amino acid chelate) — 1.00 mg
Manganese is an essential trace mineral that serves as a cofactor for key metabolic enzymes, including pyruvate carboxylase and phosphoenolpyruvate carboxykinase — enzymes critical for gluconeogenesis. Multiple population-based studies associate lower blood Manganese with higher rates of diabetes and impaired glucose regulation. The pancreas is a primary site of Manganese storage in the body, and Manganese deficiency impairs pancreatic insulin synthesis and secretion in animal models. Research also suggests Manganese may potentiate insulin action, though human intervention trials are sparse.
Gymnema sylvestre leaf powder — 50.00 mg
Gymnema sylvestre, known as the 'sugar destroyer' in Ayurvedic medicine, has been used for centuries to help manage blood sugar in India. A meta-analysis of 10 clinical studies showed significant reductions in fasting blood glucose, postprandial glucose, and HbA1c in T2DM patients. Its active gymnemic acids block sweet taste receptors and inhibit intestinal glucose absorption. A double-blind RCT demonstrated effects on both insulin secretion and insulin sensitivity in metabolic syndrome patients. Animal studies suggest gymnemic acids may also promote regeneration of pancreatic beta cells.
Banaba leaf (Lagerstroemia speciosa) — 25.00 mg
Banaba leaf has been used as a traditional anti-diabetic remedy in the Philippines for centuries. Scientific studies confirm its blood sugar-supporting effects are primarily mediated by corosolic acid and ellagitannins. Human trials show 12–30% reductions in blood glucose with Banaba extract supplementation. A 12-week placebo-controlled RCT in prediabetics demonstrated significant reductions in HbA1c, fasting plasma glucose, and HOMA-IR. A 2022 randomized, double-blind trial in metabolic syndrome patients found significant improvements in fasting glucose, insulin, waist circumference, blood pressure, and triglycerides.
Cinnamon bark powder — 50.00 mg
Cinnamon has been studied in multiple clinical trials for its ability to support fasting blood glucose levels. Active compounds including cinnamaldehyde enhance insulin receptor signaling and GLUT-4 translocation. Several meta-analyses confirm modest but significant fasting blood glucose-lowering effects in patients with type 2 diabetes and prediabetes. Cinnamon polyphenols (type-A proanthocyanidins) have been identified as insulin sensitizers that activate insulin receptor signaling. Traditional Chinese Medicine and Ayurveda have long used Cinnamon for digestive and metabolic conditions.
Guggul resin (10% extract) — 50.00 mg
Guggul is an oleo-gum resin from Commiphora wightii, valued in Ayurveda for over 3,000 years. Animal studies suggest guggulsterones may exert hypoglycemic and insulin-sensitizing effects, and an antidiabetic effect has been noted in high-fat diet-induced diabetic rats. Guggul has traditionally been used to address multiple components of metabolic health including dyslipidemia, adiposity, and insulin resistance. Preclinical studies show guggulsterones may inhibit adipocyte differentiation and induce adipocyte apoptosis.
Licorice root extract — 50.00 mg
Licorice root (Glycyrrhiza glabra) has been used worldwide as a medicine for over 4,000 years, with medicinal uses recorded in ancient Assyrian, Egyptian, Greek, and Chinese texts. Licorice contains glycyrrhizin and flavonoids that contribute to its anti-inflammatory and antioxidant properties. It appears in approximately 60% of traditional Chinese medicine prescriptions and has historically been valued for digestive and metabolic support.
Alpha lipoic acid — 30.00 mg
Alpha-lipoic acid (ALA) is an endogenous antioxidant that has been clinically evaluated for improving insulin sensitivity in type 2 diabetes. Multiple clinical trials support modest improvements in insulin sensitivity and fasting glucose. ALA activates the PI3K/Akt pathway for cellular glucose metabolism and influences energy homeostasis via AMPK activation. A meta-analysis of 12 RCTs found ALA significantly reduced fasting blood glucose and insulin resistance in metabolic syndrome patients. ALA also protects pancreatic islet cells from oxidative stress-induced damage.
L-Taurine — 25.00 mg
Taurine is a conditionally essential amino sulfonic acid widely distributed in mammalian tissues. Multiple RCTs and a 2025 systematic review and meta-analysis confirm Taurine supplementation significantly reduces fasting blood glucose, HbA1c, fasting insulin, and HOMA-IR in populations including type 2 diabetics. Taurine improves insulin signaling via the PI3K/Akt pathway and enhances pancreatic insulin secretion. A 2024 systematic review and meta-analysis of 25 RCTs found significant reductions in blood pressure, fasting blood glucose, and triglycerides.
Juniper berry 4:1 extract — 25 mg
Juniper berries (Juniperus communis) have been used medicinally since ancient Egypt. In preclinical studies, methanolic extract of juniper mediated significant reduction in blood glucose levels and increase in HDL levels in diabetic animal models. One double-blind, placebo-controlled study suggests juniper may help support blood sugar regulation. The berries contain flavonoids, volatile oils, and polyphenols with documented antioxidant activity. Native Americans traditionally used Juniper berries in the treatment of diabetes.
Huckleberry — 25 mg
Huckleberry (Vaccinium membranaceum and related species) is an anthocyanin-rich berry from the Ericaceae family. Native American groups traditionally used Huckleberry leaves and berries as a folk remedy for regulating blood sugar, a use corroborated by folk records for closely related Vaccinium species. Leaf teas containing glucoquinones and tannins were traditionally taken to reduce glycosuria and hyperglycemia. Scientific evidence from related Vaccinium species shows anthocyanins may reduce insulin resistance and enhance glucose uptake.
Yarrow flowers powder — 25.00 mg
Yarrow (Achillea millefolium) is one of the oldest known medicinal plants, used across cultures for thousands of years. Preclinical studies show Yarrow hydroalcoholic extract significantly reduces blood glucose in diabetic animal models, performing comparably to metformin. Mechanistic work identifies alpha-glucosidase inhibition, insulin sensitization, and insulin secretagogue activity. While controlled human trials for blood sugar are not yet available, the preclinical evidence is promising.
Cayenne pepper fruit powder — 10.00 mg
Cayenne pepper (Capsicum annuum) contains capsaicin, a compound that activates TRPV1 receptors in insulin-sensitive tissues. An oral glucose tolerance test study in healthy volunteers showed capsaicin increased plasma insulin and attenuated post-load blood glucose. A meta-analysis of RCTs in metabolic syndrome patients documented meaningful effects on lipid profiles and cardiometabolic risk factors. Cayenne has been used in traditional medicine systems including Ayurveda and Traditional Chinese Medicine for centuries to aid digestion and improve circulation.
Vanadyl sulfate — 1 mcg
Vanadyl sulfate is the most widely recognized supplemental form of the trace element vanadium. Small human trials report improvements in hepatic and skeletal muscle insulin sensitivity in type 2 diabetes patients. Vanadyl sulfate exhibits insulin-mimetic properties by activating insulin receptor tyrosine kinase and downstream signaling cascades. It acts at the post-receptor level in insulin signaling pathways and has been shown in clinical studies to suppress hepatic glucose production and improve peripheral insulin-mediated glucose disposal.
