Twice Daily Multi Designs for Health | Full Guide

Name: Twice Daily Multi™
Brand: Designs For Health
SKU: DH-TDM120
Price: 62.49 USD
Availability: InStock

Explore the Twice Daily Multi from Designs for Health — a science-based multivitamin with methylated B vitamins, chelated minerals, and tocotrienols.

Overview

Twice Daily Multi Designs for Health: A Science-Based Multivitamin

The Twice Daily Multi™ from Designs for Health is a comprehensive multivitamin formulated to deliver optimal amounts of nutrients not easily obtained from most diets. Available in 120 vegetarian capsules, this formula is designed around three core health priorities: methylation support, energy production, and metabolic function.

What sets the Twice Daily Multi Designs for Health apart from conventional multivitamins is the quality of its nutrient forms. Rather than relying on standard synthetic vitamins and poorly absorbed mineral salts, this formula features methylated B12 (as methylcobalamin) and methylated folate (as Quatrefolic® 5-MTHF), Vitamin E isomers delivered as DeltaGold® tocotrienols, and true amino acid chelate minerals for superior tolerance and absorption.

The product is formulated without iron, allowing the formula to focus on delivering the most important nutrients that are commonly insufficient in the modern diet. It is Non-GMO and free of gluten, dairy, and soy.

Why It Matters

Methylation, Energy, and Metabolism Support

Methylation is a critical biochemical process that occurs in every cell, supporting DNA repair, neurotransmitter synthesis, detoxification, and homocysteine metabolism. Several nutrients in the Twice Daily Multi Designs for Health directly participate in or support the methylation cycle, including methylfolate (5-MTHF), methylcobalamin (B12), pyridoxal-5-phosphate (B6), and riboflavin (B2 as FAD cofactor for MTHFR).

Energy production depends on a network of B vitamins and trace minerals that serve as cofactors for enzymes driving the citric acid cycle, electron transport chain, and macronutrient metabolism. Thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), Vitamin B6, and Vitamin B12 each play scientifically established roles in converting food into cellular ATP.

Research suggests that inadequate intake of these nutrients may contribute to fatigue, impaired cognitive function, and suboptimal metabolic performance. By providing bioavailable forms of each, the Twice Daily Multi supports the body's foundational metabolic pathways.

What's inside

Key ingredients

Vitamin A (from palmitate, mixed carotenoids) — 960 mcg

Vitamin A is a fat-soluble nutrient essential for vision, immune function, cellular differentiation, and gene regulation. In the body, preformed Vitamin A (retinol) supports the visual cycle through its metabolite 11-cis-retinal, while retinoic acid acts as a ligand for nuclear receptors that regulate the transcription of a large number of genes. Research confirms its role in supporting epithelial integrity, hematopoiesis, and the immune system.

Vitamin C (as ascorbic acid) — 500 mg

Vitamin C is a water-soluble antioxidant and essential cofactor for enzymes involved in collagen biosynthesis, carnitine synthesis, and neurotransmitter production. Research suggests it supports energy-yielding metabolism through its role in L-carnitine biosynthesis, which is required for fatty acid transport into mitochondria. It also enhances non-heme iron absorption by reducing ferric iron to its more bioavailable ferrous form and contributes to immune defense by supporting various cellular functions of both innate and adaptive immunity.

Vitamin D (as cholecalciferol) — 25 mcg

Vitamin D is a fat-soluble prohormone synthesized in the skin upon sunlight exposure and obtained from select dietary sources. After sequential hydroxylation in the liver and kidneys, its active form calcitriol binds to Vitamin D receptors found in nearly every tissue. Research suggests Vitamin D supports bone health by promoting calcium absorption, supports muscular and nervous system function, and may play a role in immune modulation. Studies have also associated Vitamin D deficiency with fatigue and low energy, with supplementation in deficient individuals shown to significantly improve fatigue outcomes.

Vitamin K (as K1 phytonadione, vitamin K2 menaquinone-4 and MenaQ7 Full Spectrum MK-6, MK-7, MK-9) — 120 mcg

Vitamin K is a fat-soluble vitamin essential for the activation of Vitamin K-dependent proteins involved in blood coagulation, bone metabolism, and cardiovascular health. Through gamma-glutamyl carboxylation, it activates osteocalcin and matrix Gla protein (MGP), which research suggests may promote calcium deposition in bone while helping to inhibit vascular calcification. MK-7 displays superior pharmacokinetics with a markedly extended half-life and higher bioavailability compared to phylloquinone. This formula provides both K1 and a full spectrum of K2 menaquinones.

Thiamin (vitamin B-1) (as thiamin HCl) — 2.3 mg

Thiamin is an essential cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase — key enzymes coupling glycolysis to the TCA cycle and enabling mitochondrial ATP production from glucose. Research confirms that thiamin plays a critical role in energy-yielding metabolism and the growth, development, and function of cells. Its active form, thiamine diphosphate (TDP), is also required by transketolase in the pentose phosphate pathway. Deficiency causes profound cellular energy failure and is linked to fatigue and impaired physical performance.

Riboflavin (vitamin B-2) — 2.8 mg

Riboflavin is the precursor to FAD and FMN, coenzymes essential for the mitochondrial electron transport chain, beta-oxidation of fatty acids, and TCA cycle function. FAD directly accepts electrons at Complex II of the ETC, making riboflavin indispensable for cellular ATP production. Importantly for methylation, riboflavin as FAD is the obligate coenzyme for MTHFR, the enzyme that converts 5,10-methyleneTHF to 5-MTHF. Research shows that riboflavin deficiency impairs MTHFR activity, reduces 5-MTHF levels, and elevates homocysteine, especially in individuals with the MTHFR 677TT genotype.

Niacin (as niacinamide and niacin) — 50 mg

Niacin is the dietary precursor to NAD⁺ and NADP⁺, the central coenzymes for over 400 enzymatic reactions including glycolysis, the TCA cycle, and oxidative phosphorylation. Research confirms niacin's critical role in cellular energy metabolism, and supplementation in mitochondrial disease has been shown to raise cellular NAD concentrations. Niacin also supports normal psychological function and contributes to the maintenance of skin and mucous membranes.

Vitamin B-6 (as pyridoxal-5-phosphate) — 5.2 mg

Provided in its active coenzyme form (PLP), Vitamin B6 serves as a cofactor for more than 140 different enzyme reactions, including amino acid metabolism, glycogen phosphorylase (for muscle energy), and neurotransmitter synthesis (serotonin, dopamine, GABA). PLP supports the methylation cycle by enabling the transsulfuration pathway — the CBS-catalyzed conversion of homocysteine to cystathionine, which clears homocysteine from the cycle. Research also supports its role in heme synthesis and immune function through interleukin-2 production.

Folate (as Quatrefolic [6S]-5-methyltetrahydrofolate, glucosamine salt) — 680 mcg

This formula provides 680 mcg of Quatrefolic® methylfolate (5-MTHF), an innovative folate form that has demonstrated high bioavailability and solubility as well as long-lasting stability. Unlike folic acid, 5-MTHF is the biologically active form of folate that directly participates in homocysteine remethylation without requiring metabolic conversion by the MTHFR enzyme — making it particularly important for the estimated portion of the population carrying reduced-function MTHFR variants. Research supports its role in one-carbon metabolism, DNA synthesis, neurotransmitter production, and red blood cell formation.

Vitamin B-12 (as methylcobalamin) — 500 mcg

Provided as methylcobalamin — one of the metabolically active forms — Vitamin B12 is essential for methionine synthase, the enzyme that remethylates homocysteine to methionine using 5-MTHF, directly sustaining the SAMe/methylation cycle. B12 is also required for methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a direct TCA cycle intermediate supporting mitochondrial ATP production. Research confirms its essential roles in red blood cell formation, neurological function, myelin synthesis, and DNA synthesis. Deficiency is among the most common and well-documented causes of chronic fatigue.

Biotin (as d-biotin) — 30 mcg

Biotin is an essential cofactor for five carboxylase enzymes that catalyze critical steps in gluconeogenesis, fatty acid synthesis and oxidation, and amino acid catabolism. These enzymes include pyruvate carboxylase (TCA cycle anaplerosis), propionyl-CoA carboxylase, and acetyl-CoA carboxylases. Research supports biotin's role in normal energy-yielding metabolism and macronutrient utilization.

Pantothenic acid (as D-calcium pantothenate) — 12 mcg

Pantothenic acid is the essential precursor to coenzyme A (CoA), which is required for the activation of acetyl groups entering the TCA cycle, fatty acid beta-oxidation, and synthesis of ATP-precursor substrates. Without adequate CoA, mitochondrial energy metabolism from carbohydrates, fats, and amino acids cannot proceed. Research also links pantothenic acid to normal mental performance, neurotransmitter synthesis (acetylcholine), and adrenal steroid production.

Iodine (as Potassium iodide) — 150 mcg

Iodine is an essential trace element required for the synthesis of thyroid hormones, which regulate metabolic rate, growth, and development. The thyroid gland concentrates iodine from the blood to produce thyroxine (T4) and triiodothyronine (T3). Adequate iodine intake supports normal thyroid function and energy-yielding metabolism.

Zinc (as Zinc bisglycinate chelate) — 15 mg

Provided as a true amino acid chelate for optimal tolerance and absorption, Zinc is required for the activity of more than 300 enzymes covering all six enzyme classes. Research supports its roles in immune regulation, DNA synthesis, energy metabolism, and insulin signaling. Zinc also functions as a structural cofactor for DNA methyltransferases (DNMTs) and BHMT in the methylation pathway. It is incorporated into approximately 10% of all human proteins, and deficiency has been associated with impaired immune function, fatigue, and poor wound healing.

Selenium (as Selenium glycinate complex) — 200 mcg

Selenium is an essential trace element incorporated into selenoproteins including glutathione peroxidases, thioredoxin reductases, and iodothyronine deiodinases. These selenoproteins participate in antioxidant defense, thyroid hormone metabolism, and maintenance of cellular redox status. Research suggests Selenium protects the mitochondrial electron transport chain from oxidative damage and supports immune function. A 4-year RCT combining Selenium and CoQ10 in elderly individuals showed improved vitality and quality of life.

Manganese (as TRAACS Manganese Bisglycinate Chelate) — 1 mg

Manganese is an essential trace mineral that serves as a cofactor for Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in the mitochondria where most cellular energy is generated. It is also the preferred cofactor for glycosyltransferases needed for cartilage and bone formation, and for pyruvate carboxylase, a key enzyme in gluconeogenesis and TCA cycle anaplerosis. Provided as a TRAACS® chelate for enhanced bioavailability.

Chromium (TRAACS Chromium nicotinate glycinate chelate) — 200 mcg

Chromium is a trace element that has been studied for its potential role in supporting insulin signaling and glucose metabolism. A systematic review and meta-analysis of 25 RCTs found that Chromium supplementation significantly improved glycemic control measures including HbA1c and fasting plasma glucose, particularly in individuals with type 2 diabetes and at doses above 200 mcg daily. Provided as a TRAACS® chelate.

Molybdenum (as TRAACS Molybdenum Glycinate Chelate) — 100 mcg

Molybdenum is an essential trace element that serves as the catalytic center of four mammalian enzymes: sulfite oxidase, xanthine oxidase, aldehyde oxidase, and mitochondrial amidoxime-reducing component (mARC). Sulfite oxidase, located in the mitochondrial intermembrane space, catalyzes the oxidation of sulfite to sulfate and transfers electrons to cytochrome c. These enzymes are involved in sulfur amino acid catabolism, purine metabolism, and drug biotransformation.

Vitamin E isomers (as DeltaGold® delta and gamma tocotrienols) — 15 mg

Rather than standard alpha-tocopherol, this formula uses DeltaGold® tocotrienols — the delta and gamma forms of the tocotrienol family. Tocotrienols have three double bonds in their phytyl tail, granting them greater mobility in biological membranes and higher antioxidant activity compared to tocopherols. Research in human trials has explored tocotrienols for their roles in supporting lipid metabolism and metabolic health parameters in diabetic and hyperlipidemic populations.

Boron (as bororganic glycine) — 2 mg

Boron is a trace mineral that participates in calcium, magnesium, and Vitamin D metabolism. In a seminal metabolic ward study, Boron supplementation (3 mg/day) in postmenopausal women reduced urinary calcium excretion by 44% and significantly elevated serum 17β-estradiol. Research also suggests Boron may influence the methylation cycle, with Boron-deprived rats showing decreased liver S-adenosylmethionine (SAM) compared to Boron-supplemented animals. Limited evidence additionally suggests Boron may facilitate insulin action.

Designs For Health

Twice Daily Multi™

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Twice Daily Multi™

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Who Benefits

Who Is the Twice Daily Multi Designed For?

The Twice Daily Multi Designs for Health is crafted as a women's and men's multivitamin suitable for adults seeking comprehensive nutritional support. It is particularly well-suited for individuals who want methylated B vitamins, which may be especially relevant for those with common MTHFR gene variants that reduce the body's ability to convert folic acid to its active form.

Because this formula is made without iron, it focuses on nutrients that are most commonly insufficient in modern diets. This makes it appropriate for individuals who already obtain adequate iron from food or who prefer an iron-free multivitamin. The formula's vegetarian capsules, Non-GMO status, and freedom from gluten, dairy, and soy make it accessible to a wide range of dietary preferences.

Adults interested in supporting their energy levels, metabolic function, and methylation pathways through superior nutrient forms — including true amino acid chelate minerals and bioactive vitamins — may find this formula particularly well-matched to their needs.

Directions

How to Take the Twice Daily Multi

Take 2 capsules per day with meals or as directed by your health-care practitioner.

Each bottle contains 120 capsules, providing a 60-day supply at the recommended serving size of 2 capsules daily. Taking the capsules with a meal that includes some dietary fat may support absorption of the fat-soluble vitamins A, D, E, and K included in the formula.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

Why does the Twice Daily Multi use methylated B vitamins?

This formula uses methylcobalamin (active B12) and Quatrefolic® methylfolate (active 5-MTHF) because these are the biologically active forms that the body can use directly without requiring enzymatic conversion. This is particularly relevant for individuals with common MTHFR gene variants, which can reduce the body's ability to convert standard folic acid to its active form. Methylated B vitamins directly support the methylation cycle — a critical biochemical pathway for homocysteine metabolism, DNA repair, neurotransmitter synthesis, and detoxification.

Why is there no iron in this multivitamin?

The Twice Daily Multi was formulated without iron to focus on nutrients that are not easily obtained in most diets. Many adults already obtain adequate iron from food, and excess iron can interfere with the absorption of other minerals such as Zinc. Individuals who need supplemental iron can work with their health-care practitioner to add it separately.

What makes DeltaGold® tocotrienols different from standard Vitamin E?

Most multivitamins use alpha-tocopherol as their Vitamin E source. The Twice Daily Multi instead provides DeltaGold® delta and gamma tocotrienols, which have three double bonds in their side chain that allow greater mobility in cell membranes and higher antioxidant activity than tocopherols. Research has explored tocotrienols for their potential to support metabolic health parameters.

What are TRAACS® chelated minerals?

TRAACS® stands for The Real Amino Acid Chelate System. This formula uses true amino acid chelate minerals — including Zinc bisglycinate chelate, Manganese bisglycinate chelate, Chromium nicotinate glycinate chelate, and Molybdenum glycinate chelate — which are designed for optimal tolerance and absorption compared to standard mineral salts.

Is the Twice Daily Multi suitable for vegetarians?

Yes. The Twice Daily Multi uses vegetarian capsules and is also Non-GMO and free of gluten, dairy, and soy.

How does this multivitamin support energy and metabolism?

The formula includes the full spectrum of B vitamins — each serving as scientifically established cofactors in energy-yielding metabolic pathways. Thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), Vitamin B6, and Vitamin B12 are all required for enzymes driving the citric acid cycle, electron transport chain, and macronutrient metabolism. Additionally, trace minerals such as Zinc, Manganese, Chromium, Selenium, and iodine support enzymatic processes involved in glucose metabolism, thyroid function, and antioxidant defense.

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