Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Choline is an essential nutrient that serves as a precursor for the synthesis of acetylcholine, a key neurotransmitter in the body involved in memory, muscle control, and various other functions. Scientific research confirms that choline is necessary for acetylcholine production. Studies show that choline deficiency can reduce acetylcholine synthesis, which may impair cognitive and neuromuscular function. Supplementation with choline has been demonstrated to increase plasma choline levels and, in some cases, acetylcholine levels in the brain, particularly in animal models.

However, while the biochemical role of choline in acetylcholine synthesis is clear, the evidence that choline supplementation enhances acetylcholine-dependent functions in healthy individuals is mixed. Some clinical studies suggest modest benefits for memory and cognitive function in elderly or cognitively impaired populations, but robust improvements in healthy adults are not consistently observed. There is stronger support for choline supplementation in cases of deficiency, such as in certain liver and neurological disorders or in populations with increased needs (e.g., pregnant women).

Overall, scientific validation exists for choline’s role in supporting the acetylcholine system at a biochemical level, and supplementation is justified when dietary intake is insufficient. However, evidence for widespread cognitive or performance enhancement in the general population is limited, resulting in a moderate evidence rating.

More about choline
More about Acetylcholine

Other ingredients that support Acetylcholine

Other body systems supported by choline

Products containing choline

Integrative Therapeutics Active B-Complex
Vitabase Active Woman's Multi
Thorne Advanced Nutrients Multivitamin
Vitabase B-Complex 100 mg Sustained Release
Thorne B-Complex #12
Thorne B-Complex #6
Designs For Health B-Supreme
Designs For Health B-Supreme
Pure Encapsulations B6 Complex
Pure Encapsulations B6 Complex
Thorne Basic B Complex
Thorne Basic Prenatal Multivitamin
Vitabase Brain Support
Pure Encapsulations Choline Bitartrate
Douglas Laboratories Choline Bitartrate
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Metagenics Glutagenics
Integrative Therapeutics Glycemic Manager
Metagenics Glycogenics
Vitabase Hair, Skin & Nails Formula
Integrative Therapeutics K-PAX MitoNutrients
Klean Athlete Klean B-Complex
Klean Athlete Klean Multivitamin ™
Vitabase Life's Essentials Plus
Metagenics Lipo-Gen™
Metagenics Lipo-Gen
Integrative Therapeutics Lipotropic Complex
Pure Encapsulations Lipotropic Detox
Thorne MediClear Plus
Thorne Men's Multi 50+
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Metagenics Multigenics®
Metagenics Multigenics Intensive Care
Metagenics Multigenics Intensive Care without Iron
Metagenics Multigenics without Iron
Integrative Therapeutics Multiplex-1 No-Iron
Pure Encapsulations NeuroMood Pure Pack
Integrative Therapeutics Nutrivitamin No-Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health PaleoMeal®
Designs For Health PaleoMeal®
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse Plus™ 570g
Metagenics PlusOne® Daily Prenatal Packs
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Pure Encapsulations PureGenomics® B-Complex
Pure Encapsulations PureGenomics® Multivitamin
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PurePals
Pure Encapsulations PurePals with Iron
Pure Encapsulations PureResponse™ Multivitamin
Thorne Stress B-Complex
Douglas Laboratories Stress-B-Plus ™
Vitabase Super Fat Burner
Vitabase Super Stress Formula
Douglas Laboratories Ultra B-Complex
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ® 2 Daily
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients