Relationship: Acne and pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Acne

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (vitamin B5) has been investigated for its potential role in treating acne, with some scientific interest but limited robust evidence. The rationale for its use is based on the role of coenzyme A, for which pantothenic acid is a precursor, in fatty acid metabolism and skin barrier function. The hypothesis is that increasing pantothenic acid intake could enhance fatty acid metabolism, possibly reducing sebum production—a key factor in acne development.

A few small clinical studies have explored high-dose pantothenic acid supplementation for acne. A notable randomized, double-blind, placebo-controlled study published in 2014 (Yang et al., Dermatology and Therapy) found that participants taking 2.2 grams/day of pantothenic acid for 12 weeks experienced a significant reduction in total facial lesions compared to placebo. However, the sample size was small (n=48), and the study has not been widely replicated. Other studies are limited in size, duration, and methodological rigor, and there is a lack of large, independent trials.

While the mechanism is plausible and preliminary data are promising, the overall quality and quantity of scientific evidence remain low, and pantothenic acid supplementation for acne is not widely endorsed in clinical guidelines. More research is needed to confirm efficacy and safety. Thus, the evidence supporting pantothenic acid for acne rates as weak/moderate (2/5) and is primarily based on limited scientific investigation rather than tradition or widespread clinical use.

More about pantothenic acid (vitamin B5)
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Other ingredients used for Acne

ajoene
aloe vera
alpha-pinene
berberine
bisabolol
black cumin
burdock
bасора
cannabis sativa oil
chamomile
cucumber
turmeric
curcumin
DIM (diindolylmethane)
epigallocatechin gallate (EGCG)
evening primrose oil
garlic bulb
green tea
hemp oil
honeysuckle
l-cystine
lactobacillus acidophilus
lactobacillus casei
lactobacillus reuteri
lactobacillus rhamnosus
lactoperoxidase
lauric acid
lavender
licorice root
monolaurin
niacinamide (vitamin B3)
omega-3 fatty acids
omega-6 fatty acids
oregon grape
pantothenic acid (vitamin B5)
phenolic acids
scrophularia root
sphaeranthus indicus
thyme
tomato
vitamin A
vitamin B
vitamin C
vitamin D
vitamin E
seaweed
zinc
shen-chu
neem tree
paederia foetida
tinospora cordifolia
blackboard tree
chrysanthemum
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oriental arborvitae
trace minerals
anemarrhena asphodeloides
fulvic acid
herbal blend (proprietary)
melaleuca alternifolia
indigo leaves
15,16-Dihydrotanshinone I
Ash
Apple Cider Vinegar
Alpha-terpineol
Azelaic acid
Allicin
Abrus
Andrographolide
Alpha Hydroxy Acids
Allantoin
Asteracea
Argan nut oil
Anemarrhena
Bee Propolis
Black Seed
Babchi
Baphicacanthus cusia
Bidens pilosa
Banyan
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Bassia scoparia
Coconut
Caryophyllene
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Chlorophyllin
Carvacrol
Curcuminoid
Chinese Raisintree
Curcumen
Centipeda
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Castile Soap
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Clerodendrum indicum
Cannabichromene
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Dianthus
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Estrogen

Other health conditions supported by pantothenic acid (vitamin B5)

Acne
Adrenal Fatigue
Burning Feet or Hands
Energy (lack of)
Fatigue
Hair (loss or thinning)

Products containing pantothenic acid (vitamin B5)

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Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Acne

Table of Contents

Synopsis

Other ingredients used for Acne

Other health conditions supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

Health Concerns

Brands

Evidence supporting the use of: Pantothenic acid (vitamin B5)For the health condition: Acne

Table of Contents

Synopsis

Other ingredients used for Acne

Other health conditions supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Acne