Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (vitamin B5) has been investigated for its potential role in treating acne, with some scientific interest but limited robust evidence. The rationale for its use is based on the role of coenzyme A, for which pantothenic acid is a precursor, in fatty acid metabolism and skin barrier function. The hypothesis is that increasing pantothenic acid intake could enhance fatty acid metabolism, possibly reducing sebum production—a key factor in acne development.

A few small clinical studies have explored high-dose pantothenic acid supplementation for acne. A notable randomized, double-blind, placebo-controlled study published in 2014 (Yang et al., Dermatology and Therapy) found that participants taking 2.2 grams/day of pantothenic acid for 12 weeks experienced a significant reduction in total facial lesions compared to placebo. However, the sample size was small (n=48), and the study has not been widely replicated. Other studies are limited in size, duration, and methodological rigor, and there is a lack of large, independent trials.

While the mechanism is plausible and preliminary data are promising, the overall quality and quantity of scientific evidence remain low, and pantothenic acid supplementation for acne is not widely endorsed in clinical guidelines. More research is needed to confirm efficacy and safety. Thus, the evidence supporting pantothenic acid for acne rates as weak/moderate (2/5) and is primarily based on limited scientific investigation rather than tradition or widespread clinical use.

More about pantothenic acid (vitamin B5)
More about Acne

Other ingredients used for Acne

Other health conditions supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

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Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
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Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
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