Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (vitamin B5) is essential for the synthesis of coenzyme A (CoA), which plays a central role in energy metabolism and the biosynthesis of steroid hormones, including those produced by the adrenal cortex. Historically, pantothenic acid deficiency in animals has been shown to cause adrenal atrophy and impaired adrenal function. Early studies (e.g., Fry et al., 1943) demonstrated that pantothenic acid is required for adrenal health in rats, supporting its traditional use as an "adrenal tonic" in some nutritional circles.

However, direct scientific evidence in humans for pantothenic acid supplementation enhancing or supporting adrenal cortex function in non-deficient individuals is limited. While the vitamin is undeniably necessary for the normal production of adrenal hormones (such as cortisol), clinical trials demonstrating a benefit of supplementation beyond correcting deficiency are lacking. Most individuals consuming a typical diet obtain sufficient pantothenic acid, and overt deficiency is rare. Thus, while the rationale for its importance to adrenal function is biochemically sound, there is insufficient evidence to support supplementation for adrenal health in people with adequate intake.

In summary, pantothenic acid is scientifically recognized as essential for adrenal cortex function due to its role in hormone biosynthesis; however, the evidence supporting supplementation for adrenal support in the absence of deficiency is weak, justifying a moderate-low evidence rating.

More about pantothenic acid (vitamin B5)
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