Relationship: Anemia and vitamin B12

Evidence supporting the use of: Vitamin B12
For the health condition: Anemia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B12 is scientifically validated as an essential treatment for certain types of anemia, particularly megaloblastic anemia and pernicious anemia. These conditions arise due to a deficiency of vitamin B12, which is crucial for DNA synthesis in red blood cell production. Without adequate B12, red blood cell precursors in the bone marrow cannot mature properly, resulting in large, immature, and dysfunctional red blood cells—a hallmark of megaloblastic anemia.

The connection between B12 and anemia was first recognized in the early 20th century, when pernicious anemia was a fatal disease until it was discovered that consuming liver (rich in B12) could reverse the symptoms. Subsequent research identified vitamin B12 as the critical factor in treating this disorder. Today, deficiency is diagnosed through blood tests, and standard therapy involves oral or intramuscular B12 supplementation, which reliably corrects anemia and prevents neurological complications.

Numerous clinical studies and decades of clinical practice confirm that vitamin B12 supplementation rapidly restores normal red blood cell production in deficient individuals, with improvement often seen within days to weeks. In contrast, B12 has no effect on anemias not caused by B12 deficiency. Thus, scientific evidence robustly supports the use of vitamin B12 for anemias resulting from its deficiency, earning this application the highest evidence rating.

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black cumin
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bovine
bovine liver
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Evidence supporting the use of: Vitamin B12
For the health condition: Anemia

Table of Contents

Synopsis

Other ingredients used for Anemia

Other health conditions supported by vitamin B12

Products containing vitamin B12

Health Concerns

Brands

Evidence supporting the use of: Vitamin B12For the health condition: Anemia

Table of Contents

Synopsis

Other ingredients used for Anemia

Other health conditions supported by vitamin B12

Products containing vitamin B12

Evidence supporting the use of: Vitamin B12
For the health condition: Anemia