Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in supporting or treating anxiety, with some scientific rationale behind its use, though the strength of evidence is limited. Vitamin B6 is essential in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA)—all of which play important roles in mood regulation and the anxiety response. Deficiency in B6 can lead to symptoms including irritability, confusion, and, in rare cases, anxiety-like symptoms. Several small-scale studies and clinical trials have explored the effect of B6 supplementation on anxiety. For instance, a 2022 randomized controlled trial found that high-dose vitamin B6 supplementation over one month led to a modest reduction in self-reported anxiety, possibly due to enhanced GABAergic activity. However, other studies have been mixed or inconclusive, and many have methodological limitations such as small sample size or lack of placebo controls. B6 is sometimes included in multivitamin formulations marketed for stress or mood support, and it is occasionally recommended by healthcare professionals for patients with confirmed B6 deficiency or as part of a broader strategy for supporting neurotransmitter balance. Nevertheless, there is not yet robust clinical evidence to support standalone vitamin B6 supplementation as an effective treatment for anxiety disorders in the general population. More large-scale, well-controlled studies are needed to clarify its therapeutic potential.

More about vitamin B6
More about Anxiety

Other ingredients used for Anxiety

Other health conditions supported by vitamin B6

Products containing vitamin B6

Thorne 5-Hydroxytryptophan
Designs For Health 5-HTP Supreme™
Designs For Health 5-HTP Synergy™
Designs For Health Acnutrol™ capsules
Integrative Therapeutics Active B-Complex
Vitabase Active Man's Formula
Vitabase Active Woman's Multi
Designs For Health Adrenal Complex
Designs For Health Adrenal Complex
Metagenics Adrenogen
Designs For Health Adrenotone™
Designs For Health Adrenotone™
Metagenics AdvaClear
Metagenics AdvaClear
Thorne Advanced Bone Support Oscap
Thorne Advanced Nutrients Multivitamin
Designs For Health Amino Acid Supreme™
Designs For Health Amino Acid Synergy
Pure Encapsulations Amino-NR
Pure Encapsulations Amino Replete
Metagenics Axis Endo™ Mango
Douglas Laboratories B-Complex
Vitabase B-Complex 100 mg Sustained Release
Thorne B-Complex #12
Thorne B-Complex #6
Pure Encapsulations B-Complex Plus
Pure Encapsulations B-Complex Plus
Designs For Health B-Supreme
Designs For Health B-Supreme
Pure Encapsulations B6 Complex
Pure Encapsulations B6 Complex
Thorne Basic B Complex
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Pure Encapsulations CarbCrave Complex
Thorne Catalyte
Designs For Health CatecholaCalm™
Metagenics Ceralin® Forte
Vitabase Cholesterol Support
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change Daily Essentials
Integrative Therapeutics Clinical Nutrients HP
Metagenics Collagenics®
Metagenics Cortico-B5B6®
Designs For Health CraveArrest™
Thorne Craving and Stress Support Relora Plus
Integrative Therapeutics Detoxication Factors
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health DFH Complete Multi™ with Copper & Iron
Designs For Health DopaBoost™
Pure Encapsulations DopaPlus
Integrative Therapeutics EHB
Pure Encapsulations Emotional Wellness
Pure Encapsulations Emotional Wellness
Designs For Health EndoTrim™
Metagenics Endura® Lemonade
Pure Encapsulations Energize Plus™ Pure Pack
Metagenics EstroFactors®
Metagenics Fem EstroPlex®
Metagenics Fem Prenatal®
Designs For Health FemGuard+Balance™
Thorne Ferrasorb
Metagenics Fibroplex®
Pure Encapsulations Folate 5,000 Plus
Metagenics GI Sustain™ Powder
Metagenics Glutagenics
Integrative Therapeutics Glycemic Manager
Metagenics Glycogenics
Vitabase Hair, Skin & Nails Formula
Vitabase Healthy Sleep Support
Metagenics Hemagenics
Metagenics Hemagenics
Metagenics HerSynergy®
Pure Encapsulations Homocysteine Factors
Pure Encapsulations Homocysteine Factors
Designs For Health Homocysteine Supreme™
Designs For Health Homocysteine Supreme™
Designs For Health Insomnitol™ Capsules
Designs For Health Insomnitol™ Chewables
Integrative Therapeutics K-PAX MitoNutrients
Metagenics Ketogenic Shake Chocolate
Metagenics Ketogenic Shake Vanilla
Klean Athlete Klean B-Complex
Klean Athlete Klean Electrolytes ™
Klean Athlete Klean Multivitamin ™
Pure Encapsulations L-Tryptophan
Pure Encapsulations L-Tryptophan
Douglas Laboratories L-Tryptophan
Vitabase Life's Essentials Plus
Metagenics Lipo-Gen™
Metagenics Lipo-Gen
Designs For Health Liposomal B Supreme
Integrative Therapeutics Lipotropic Complex
Pure Encapsulations Lipotropic Detox
Pure Encapsulations Liquid B-Complex
Pure Encapsulations Liquid Magnesium
Douglas Laboratories Liquid Multivitamin
Pure Encapsulations LiquiNutrients
Designs For Health LV-GB Complex™
Thorne MediClear Plus
Thorne Men's Multi 50+
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaGlycemX™
Metagenics MetaGlycemX
Metagenics MetaKids Multi Soft Chew Grape
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Metagenics MetaRelax®
Thorne Methyl-Guard
Thorne Methyl-Guard Plus
Pure Encapsulations MethylAssist
Metagenics MethylCare
Designs For Health Mitochondrial NRG™
Metagenics MitoVive
Pure Encapsulations MotilPro
Pure Encapsulations Multi t/d
Pure Encapsulations Multi t/d
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Metagenics Multigenics®
Metagenics Multigenics Chewable Orange
Metagenics Multigenics Intensive Care
Metagenics Multigenics Intensive Care without Iron
Metagenics Multigenics without Iron
Integrative Therapeutics Multiplex-1 No-Iron
Designs For Health NeuroCalm™
Designs For Health Neurolink™
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations NeuroPure
Designs For Health NeuroRenew™
Pure Encapsulations NR Longevity
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950® A without Copper & Iron
Pure Encapsulations Nutrient 950® with NAC
Pure Encapsulations Nutrient 950® with Vitamin K
Pure Encapsulations Nutrient 950® without Copper, Iron & Iodine
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations Nutrient 950® without Iron
Integrative Therapeutics Nutrivitamin No-Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Designs For Health OcuForce™
Integrative Therapeutics Osteoprime Forte
Integrative Therapeutics Osteoprime Ultra
Designs For Health P-5-P
Pure Encapsulations P-5-P 50
Pure Encapsulations P-5-P 50
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health PaleoMeal®
Designs For Health PaleoMeal®
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse
Designs For Health Plant Protein Cleanse Plus™ 570g
Designs For Health Plant Protein Meal
Designs For Health Plant Protein Meal Plus
Designs For Health Plant Protein Meal
Metagenics PlusOne® Daily Prenatal Packs
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Vitabase Prostate Complex (Formerly Prostate Complete)
Designs For Health Prostate Supreme™
Designs For Health Prostate Supreme™
Integrative Therapeutics ProThrivers Multivitamin
Pure Encapsulations PureGenomics® B-Complex
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureLean® Protein
Pure Encapsulations PurePals
Pure Encapsulations PurePals with Iron
Pure Encapsulations PureResponse™ Multivitamin
Thorne Pyridoxal 5 Phosphate B6
Pure Encapsulations Rapid Calm
Vitabase Relaxation Support
Douglas Laboratories Relora ®-Plex
Metagenics Renagen™ DTX
Pure Encapsulations RevitalAge™ Nerve
Designs For Health S-Acetyl Glutathione Synergy
Designs For Health SAMe
Designs For Health SAMe
Pure Encapsulations SeroPlus
Metagenics SeroSyn
Thorne Stress B-Complex
Douglas Laboratories Stress-B-Plus ™
Thorne Stress Balance Phytisone
Designs For Health StressArrest™
Vitabase Super Antioxidant Formula
Vitabase Super Fat Burner
Vitabase Super Stress Formula
Metagenics Testralin®
Metagenics Trancor®
Designs For Health Twice Daily Essential Packets
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Douglas Laboratories Ultra B-Complex
Pure Encapsulations Ultra B-Complex with PQQ
Douglas Laboratories Ultra Benfotiamine
Metagenics Ultra Glucose Control® Chocolate
Metagenics Ultra Glucose Control Chocolate
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Glucose Control Vanilla
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ® 2 Daily
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Metagenics Ultra Prostagen Concentrated
Douglas Laboratories Ultra Protein Green
Pure Encapsulations Ultra Pure Pack
Metagenics UltraClear Detox Powder
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Douglas Laboratories Uro-Pro ®
Designs For Health UT Synergy™
Pure Encapsulations VisionPro Nutrients
Designs For Health Vitamin B-6 Liquid
Designs For Health Weight Loss Support Packets
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets
Designs For Health Zinc Supreme™