Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacinamide (vitamin B3) has been explored as a possible adjunct treatment for osteoarthritis and rheumatoid arthritis, primarily based on a small body of clinical research and some historical reports. The most notable evidence comes from a series of studies conducted by Dr. William Kaufman in the 1940s and 1950s, followed by a small double-blind, placebo-controlled pilot study published in 1996 in Inflammation Research by Dr. Jonathan Prousky and others. These studies suggest that niacinamide at high doses (often several grams per day) may help reduce symptoms such as joint stiffness, improve joint mobility, and decrease the need for anti-inflammatory medications in some patients. The proposed mechanisms include anti-inflammatory effects, enhancement of cartilage repair, and improved synovial fluid production. However, these findings have not been widely replicated in larger, high-quality clinical trials, and the evidence remains limited and somewhat outdated. No major medical organizations currently recommend niacinamide as a standard arthritis therapy. While there are some reports of benefit, the scientific consensus is that the evidence is weak (rated 2/5), and niacinamide should not replace established arthritis treatments. Potential side effects at high doses (such as liver toxicity) also warrant caution. More rigorous research is needed to confirm its efficacy and safety for arthritis patients.

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Other ingredients used for Arthritis

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