Relationship: Brain and niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the body system: Brain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacinamide (vitamin B3) is scientifically recognized as essential for normal brain function due to its role as a precursor for nicotinamide adenine dinucleotide (NAD⁺) and nicotinamide adenine dinucleotide phosphate (NADP⁺), which are critical cofactors in cellular energy metabolism and DNA repair. Severe deficiency of niacin (pellagra) leads to neurological symptoms such as confusion, depression, and memory loss, demonstrating its necessity for the brain. Some clinical studies and animal models suggest that niacinamide may have neuroprotective effects, possibly by reducing oxidative stress and inflammation, and by supporting mitochondrial function. There is ongoing research into its potential benefits in neurodegenerative diseases such as Alzheimer's and Parkinson's, but robust clinical evidence for supplemental use in these conditions is limited. Current support for niacinamide in brain health is grounded primarily in its ability to prevent deficiency-related neurological symptoms, with moderate evidence for additional neuroprotective effects. Thus, while niacinamide is scientifically validated as essential for brain health at nutritional levels, evidence for its use beyond correcting deficiency—such as for cognitive enhancement or disease prevention—is still emerging and not yet conclusive.

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Other body systems supported by niacinamide (vitamin B3)

Arteries
Blood
Brain
Circulatory System
Hepatic System
Immune System
Liver
Mitochondria
Nerves
Skin

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Evidence supporting the use of: Niacinamide (vitamin B3)
For the body system: Brain

Table of Contents

Synopsis

Other ingredients that support Brain

Health Concerns

Brands

Evidence supporting the use of: Niacinamide (vitamin B3)For the body system: Brain

Table of Contents

Synopsis

Other ingredients that support Brain

Other body systems supported by niacinamide (vitamin B3)

Products containing niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the body system: Brain