Relationship: Brain and pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the body system: Brain

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (vitamin B5) plays an essential role in human metabolism as a component of coenzyme A, which is necessary for the synthesis and oxidation of fatty acids and the metabolism of carbohydrates and proteins. This broad metabolic function is important for all tissues, including the brain. Deficiency of pantothenic acid is rare but, when present, can cause symptoms such as fatigue, irritability, numbness, and neurological disturbances (e.g., paresthesia, also known as "burning feet syndrome"). Animal studies and rare reports in humans have shown that severe deficiency can impact brain function, likely due to impaired energy metabolism and neurotransmitter synthesis (notably acetylcholine).

However, there is limited evidence that supplementing with pantothenic acid above the recommended dietary allowance supports cognitive performance or brain health in healthy individuals. Most research focuses on preventing deficiency rather than enhancing brain function. Some preliminary studies suggest a possible role in stress response or mood, but results are inconsistent and mechanisms are not well established. Overall, the use of pantothenic acid to support the "brain body system" is scientifically plausible in the context of deficiency, but there is insufficient evidence to support its use as a cognitive enhancer or neuroprotective supplement in those with adequate intake. Thus, the evidence rating is 2 (limited scientific support, mainly for deficiency correction).

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Other body systems supported by pantothenic acid (vitamin B5)

Adrenal Cortex
Adrenal Glands
Brain
Cortisol
Glandular System
Hair
Mitochondria
Nerves
Skin

Products containing pantothenic acid (vitamin B5)

Health Concerns

Brands

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the body system: Brain

Table of Contents

Synopsis

Other ingredients that support Brain

Other body systems supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

Health Concerns

Brands

Evidence supporting the use of: Pantothenic acid (vitamin B5)For the body system: Brain

Table of Contents

Synopsis

Other ingredients that support Brain

Other body systems supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the body system: Brain