Relationship: Cancer (prevention) and folate

Evidence supporting the use of: Folate
For the health condition: Cancer (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Folate (vitamin B9) has a scientifically explored but complex relationship with cancer prevention. Folate is crucial for DNA synthesis, repair, and methylation, processes that are fundamental in maintaining genomic stability and preventing mutations that could lead to cancer. Epidemiological studies have shown that low folate status is associated with an increased risk of certain cancers, particularly colorectal cancer. Some clinical trials and meta-analyses suggest that adequate dietary intake of folate may reduce the risk of developing some cancers, supporting its role in cancer prevention.

However, the evidence is not unequivocal. Some studies indicate that excessive folate intake, especially from supplements, may have the opposite effect in certain populations, potentially promoting the progression of existing precancerous lesions. Thus, while there is scientific validation for folate’s role in supporting DNA integrity and possibly reducing cancer risk when consumed at recommended dietary levels, high-dose supplementation is not universally endorsed for cancer prevention and may even be contraindicated in some cases. Current guidelines recommend meeting folate needs through a balanced diet rather than supplements for cancer prevention.

In summary, folate’s use in cancer prevention has a scientific basis, but the overall strength of evidence is moderate (rated 2/5), with recommendations favoring dietary folate rather than supplementation, and with some caution in specific populations.

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15,16-Dihydrotanshinone I
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7-hydroxymatairesinol (HMR)
8-Bromo-7-Methoxychrysin
Abalone
Acacetin
Acai berry
Acemannan
Acetogenin
Achyranthes
Adzuki bean
Agarikon Mushroom
AHCC
Ajoene
Akkermansia muciniphila
Alantolactone
Albizia
Algae
algal oil
Algal protein
Allicin
Alliin
Allium tuberosum
Allophycocyanin
Allyl isothiocyanate
Allyl mercaptan
Allyl sulfide
Alpha-carotene
alpha-humulene
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpha-methylselenobutanoic acid
alpinia galangal
amentoflavone
American Pawpaw
amethoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
amygdalin
anamu
Andrographis
andrographolide
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
anti-aromatase
Antrodia camphorata
apigenin
apple
apricot
arabinoxylan
Aralia
arctiin
Ardisia
Arjunolic acid
Armillaria mellea
Aronia melanocarpa
Artepillin C
arugula
ashitaba
ashwagandha
astaxanthin
aster root
Asteraceae
astragalin
astragaloside
astragalus
atractylone
Auricularia
avocado
bacteria
bael
baicalein
baicalin
Baikal Skullcap
banyan
baobab
barbasco
barberry
barley
Basidiomycota
basil
Bassia scoparia
Bauhinia
bayleaf
bean
bee pollen
bee products
bee propolis
Beef liver
beet
benzyl isothiocyanate
berberine
bergenin
berry
beta and delta tocopherols
beta caryophyllene
beta-carotene
beta-glucan
beta-lapachone
beta-sitosterol
betanin
betulinic acid
Bidens pilosa
bignay
biochanin
biota seed
black cumin
black galingale
black garlic
black ginger
black seed
black tea
black walnut
blackberry
blueberry
Boerhavia diffusa
bok choy
Bombax
Borassus aethiopum
Boswellia
bran
branched-chain amino acids
Brassica
Brazil nut
breadnut
broccoli
Brussel sprouts
Buckwheat
burdock
Butea monosperma
butein
butenyl isothiocyanate
butyrate triglyceride
butyric acid
C-phycocyanin
cabbage
Caesalpinia crista
caffeic Acid
calycosin
Camellia sinensis
cancerina
capillary artemisia
capsaicin
capsaicinoids
capsanthin
capsicum
carnosic acid
carnosol
carotene (unspecified)
carrot
carvacrol
caryophyllene
casticin
cat's claw
catechins
caterpillar mushroom
cauliflower
cayenne pepper
Celastrus
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chaga mushroom
chalcone
champignon
cherry
chia seed
Chinese fleeceflower
Chinese Ligustrum berry
Chinese mountain ant
Chinese salvia root
chirata
chlorella
chlorogenic acid
chlorophyll
chlorophyllin
chocolate
chokeberry
Chordaria cladosiphon
chrysanthemum
cinnamaldehyde
cinnamic acid
Cinnamomum
cinnamon
cistanche
Citrus
citrus bioflavonoids
citrus pectin
Clostridium butyricum
clove
cocoa
coconut oil
cod liver oil
coix
collard
commiphora
condurango
conjugated linoleic acid (CLA)
Coprinus
cordyceps
corilagin
coriolus mushroom
costus
coumaric acid
cowage seed
cowherb
crocetin
cruciferous
cryptoxanthin
Cucurbita
cumin
Curcuma
curcumen
curcumin
Curcuminoid
curry leaf
cyanidin
cyanobacteria
cynaropicrin
Cynomorium
cytokines
d-alpha tocopherol
d-glucarate
daidzein
daidzin
date
decursin
delphinidin
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl sulfide
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Dichrostachys glomerata
didymin
Dihydrocapsaicin
DIM (diindolylmethane)
diosgenin
diosmetin
dithiolthiones
DNA
docosahexaenoic Acid
dodder
dong quai root
DPA (docosapentaenoic acid)
Dumontiaceae
Dunaliella
Dunaliella salina
E-Viniferin
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equol (proprietary)
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fiber
fiber blend (proprietary)
fisetin
fish
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Flammulina velutipes
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Flueggea suffruticosa
fo-ti
folate
Fomitopsis pinicola
formononetin
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fucoidan
fucosterol
fucoxanthin
fungus
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gallate
gallic acid
gamma tocopherol
ganoderma
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Garcinone A
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Gigartina
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Glutathione
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Graviola
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greens blend (proprietary)
Guava
Gypenoside
Haematococcus pluvialis
heal-all
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Herb Robert
hericium mushroom
hesperetin
hesperidin
hibiscus
HMR lignan
Honokiol
Huang hua
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hydroxytyrosol
Hyperoside
Hyphomycetes
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icariin
Indian coraltree
Indian fagonia
Indian sarsparilla
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indigo leaves
indole-3-carbinol
iridoids
Isatis
Isoalantolactone
isodon rubescens
isoflavones
isoliquiritigenin
isoquinoline alkaloids
isosilybin
isothiocyanates
isovitexin
Jaboticaba
Java brucea
jiaogulan
Job\'s tears
jujube
Kaempferol
kale
Kefir
Kefiran
kelp
kiwi
knotweed
Kohlrabi
Kokilaksha
Kombucha
Lactoferrin
Laggera pterodonta
Laminaria
Lapachol
Lebbek
Legume protein
lemon
lemongrass
Lentil
Lentinan
Lentinula edodes mycelia
Leptadenia
lichen
lignans
Ligusticum
Ligustrazin
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limonene
Limonium sinense
limonoid
lingzhi
lion's mane
long pepper
loquat
Loranthus
lotus
lupulone
lutein
luteolin
lychee
Lycium
lycopene
Lycoris
Macaranga indica
Maclura tricuspidata
magnolol
maitake mushroom
malvidin
mangiferin
mangostanol
mangosteen
mangostene xanthone
mangostin
marigold
Marine fat
Marine lipid
Marine protein
Maslinic acid
Matcha
Mayapple
Maytenus ilicifolia
medium chain triglycerides (MCT)
Melia
Mesima
Methoxylated flavones
Methylselenocysteine
Milk Protein
Millettia
mixed carotenoids
Momordica
Momordicosides
Mondo grass
Monoterpenes
Morinda
Moringa
Morus
Mulberry
Mushroom
mustard seed
Myricetin
Myricitrin
Myrosinase
Myrrh
Naphthoquinones
Naringenin
Naringin
Neem tree
Neoandrographolides
Nettle
Niacinamide (vitamin B3)
Nigella seed
Nobiletin
Nomilin
noni
nopal
nut grass
oleanolic acid
oleic acid
Oleuropein
Oligomeric proanthocyanidins
Oligosaccharides
olive
omega-3 fatty acids
onion
Onosma bracteatum
oolong tea
orange
Oroxylum indicum
Osmanthus
Osthole
oyster mushroom
pagoda tree
Pansit-pansitan
papaya
Paris polyphylla
parsley
parthenolide
pau d'arco
paw paw
Pentacyclic triterpenoids
Pepper
perilla
Periwinkle
Persimmon
Petiveria
Phaeophyceae
Phellodendron
phellodendron amurense
Phenethyl isothiocyanate (PEITC)
phenolic compounds
Phenylpropanoids
phlorotannins
Phthalides
Phycocyanin
Physalis angulata
Phytoecdysteroid
Phytoestrogens
phytosterols
Piceid
pineapple
Piper nigrum
Piperine
Pistachio
Pleurotus eryngii
plum fruit
Podophyllum
Pokeweed
Polydatin
Polygonatum
Polygonum
polymethoxylated flavones
polyphenols
polyporous mushroom
polysaccharides
pomegranate
pomelo
Poncirin
Portulaca
proanthocyanidins
procyanidin
Propionibacterium freudenreichii
Propolis
protein
Puerarin
pumpkin
punicalagins
punicic acid
punicosides
purslane
Pyrrosia
quail egg
quercetin
quinoa
radish
raspberry
red clover
reishi mushroom
resveratrol
Rhabdosia rubescens
rhizome
rhubarb
root tuber
Rosa roxburghii
rosemary
rosmarinic acid
royal jelly
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
rutin
S-allylcysteine
Salidroside
Salmon Oil
Salvianolic acid
Sapogenin
saponins
Sargassum
Schisandrins
Schizophyllum commune
seaweed
secoisolariciresinol diglucoside
Selaginella
selenium
Selenocysteine
Selenomethionine
Semecarpus anacardium
sesame
Sesamin
Sesbania
Sesquiterpenes
Sete sangrias
shen-chu
shiitake mushroom
Shilajit
Shogaol
Sichuan Lovage
Silybin
Sinensetin
Sinigrin
Smartweed
smilax
Solanum indicum
Sophora
Sotetsuflavone
soursop
Soy
soy isoflavones
Soy Protein
soybean
Sphaeranthus indicus
spinach
spirulina
stigmasterol
Stilbenoid
strawberry
Sulfated polysaccharide
Sulforaphane
sulforaphane glucosinolate
suma
Sword Bean
Syringic acid
Tangeretin
Tanshinone
Taraxasterol
Taxifolin
Tea
Terpenoids
Theaflavin
Thiosulfinate
Thistle
Thymoquinone
Thymus
Tiliroside
Tinospora cordifolia
tocotrienols
Trametes
Trans-pterostilbene
Tremella
tributyrin
Triphala
Triterpenes
Tulbaghia
Tumerone
Turkey tail mushroom
turmeric
Turmerones
Tylophorine
typhonium
Typhonium flagelliforme
Uncaria
Urolithin A
Ursolic Acid
vegetable and fruit blend (proprietary)
Vegetable Protein
Verbascoside
Vestitol
Vicenin
Vine tea
Viniferin
vitamin A
vitamin B
vitamin C
vitamin D
vitamin D3
Vitexin
Wakame
Walnut
Wasabi
Water Pepper
Watercress
Wax Gourd
wheat germ
wheat grass
Whey protein
White Tea
Withanolides
Wogonin
Xanthohumol
Xanthone
Xanthoparmelia
Xanthophyll
Xanthorrhizol
Xylaria nigripes
Yacon
Yellow root
Yerba mate
Yumberry
Yuzu
zanthoxylum
Zedoary
Zinc
Zingerone
Zingiberene
Zucchini

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: Folate
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Cancer (prevention)