Relationship: Cancer (prevention) and folate

Evidence supporting the use of: Folate
For the health condition: Cancer (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Folate (vitamin B9) has a scientifically explored but complex relationship with cancer prevention. Folate is crucial for DNA synthesis, repair, and methylation, processes that are fundamental in maintaining genomic stability and preventing mutations that could lead to cancer. Epidemiological studies have shown that low folate status is associated with an increased risk of certain cancers, particularly colorectal cancer. Some clinical trials and meta-analyses suggest that adequate dietary intake of folate may reduce the risk of developing some cancers, supporting its role in cancer prevention.

However, the evidence is not unequivocal. Some studies indicate that excessive folate intake, especially from supplements, may have the opposite effect in certain populations, potentially promoting the progression of existing precancerous lesions. Thus, while there is scientific validation for folate’s role in supporting DNA integrity and possibly reducing cancer risk when consumed at recommended dietary levels, high-dose supplementation is not universally endorsed for cancer prevention and may even be contraindicated in some cases. Current guidelines recommend meeting folate needs through a balanced diet rather than supplements for cancer prevention.

In summary, folate’s use in cancer prevention has a scientific basis, but the overall strength of evidence is moderate (rated 2/5), with recommendations favoring dietary folate rather than supplementation, and with some caution in specific populations.

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algal oil
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alpha-linolenic acid (ALA)
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apple
apricot
ashwagandha
astaxanthin
astragalus
barberry
barley
basil
beet
berberine
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beta and delta tocopherols
beta caryophyllene
beta-carotene
beta-glucan
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bisabolol
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black garlic
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sesame
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blueberry
branched-chain amino acids
broccoli
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burdock
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capsaicinoids
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cat's claw
catechins
caterpillar mushroom
cauliflower
chaga mushroom
champignon
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chia seed
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chlorella
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citrus bioflavonoids
citrus oil
citrus pectin
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cordyceps
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fiber blend (proprietary)
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fruit and vegetable blend (proprietary)
gamma tocopherol
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ginseng
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polysaccharides
pagoda tree
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procyanidin
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punicalagins
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punicic acid
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Rosa roxburghii
rhubarb
Sapogenin
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Sete sangrias
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Salidroside
Silybin
Syringic acid
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Sinigrin
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Schisandrins
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saponins
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Sulfated polysaccharide
Shilajit
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S-allylcysteine
Sesamin
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Thymoquinone
Tumerone
Thymus
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Triterpenes
Typhonium flagelliforme
Tangeretin
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Tiliroside
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Tremella
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Ursolic Acid
Vestitol
Vegetable Protein
Vine tea
Vitexin
Viniferin
Vicenin
Verbascoside
Withanolides
White Tea
Wax Gourd
Wogonin
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Products containing folate

Health Concerns

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Evidence supporting the use of: Folate
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Cancer (prevention)