Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacinamide (vitamin B3) is an essential nutrient involved in DNA repair and cellular metabolism. Its use in cancer prevention and support is primarily rooted in scientific investigation rather than traditional medicine. Several preclinical studies and some clinical research suggest niacinamide may have chemopreventive effects, particularly in skin cancer. The most significant human evidence comes from the ONTRAC study (New England Journal of Medicine, 2015), a randomized controlled trial that demonstrated oral niacinamide (500 mg twice daily) reduced the rate of new non-melanoma skin cancers in high-risk individuals by about 23%. The proposed mechanisms include enhancement of DNA repair, reduction of immunosuppression caused by UV radiation, and anti-inflammatory effects. However, the evidence for niacinamide’s benefit in preventing or treating other types of cancer is limited and mainly based on laboratory or animal models. There is not enough high-quality clinical data to justify its broad use for cancer prevention outside of specific indications, such as non-melanoma skin cancer in high-risk individuals. No major guidelines currently recommend niacinamide for general cancer prevention or treatment, and its use should be considered adjunctive rather than primary. Therefore, while there is scientific backing for a specific context, the overall evidence strength is modest (rated 2/5).

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