Relationship: Cancer Treatment (reducing side effects) and folate

Evidence supporting the use of: Folate
For the health condition: Cancer Treatment (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folate (vitamin B9) is scientifically validated in the context of cancer treatment, primarily as a means to reduce the side effects of certain chemotherapy agents, rather than as a direct anticancer agent. The most notable use is with the drug methotrexate, a folate antagonist used in the treatment of various cancers (such as leukemia, breast cancer, and osteosarcoma) as well as autoimmune diseases. Methotrexate inhibits dihydrofolate reductase, disrupting DNA synthesis and cell replication. While this is beneficial for targeting rapidly dividing cancer cells, it also affects normal cells, causing significant toxicity (e.g., mucositis, myelosuppression, and gastrointestinal side effects). To mitigate this toxicity, a form of folate called leucovorin (folinic acid) is administered after methotrexate therapy, a strategy known as "leucovorin rescue." Leucovorin provides a source of reduced folate that can bypass the methotrexate-induced block, selectively rescuing normal cells without significantly protecting cancer cells. Multiple controlled clinical studies and decades of clinical practice have established the efficacy of this approach in reducing methotrexate toxicity, making folate supplementation a standard part of high-dose methotrexate regimens. Additionally, folate is sometimes supplemented during treatment with other antifolate agents (like pemetrexed) to reduce toxicities. However, folate supplementation is not generally recommended as a cancer preventive or direct treatment, as excessive folate may, in some contexts, promote tumor growth. Thus, its clinical use is carefully tailored and evidence-based for reducing side effects of specific chemotherapy drugs.

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akkermansia muciniphila
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aloe vera
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
astragalus
bacillus coagulans
bacillus subtilis
basil
beet
berberine
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beta caryophyllene
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bifidobacterium bifidum
bifidobacterium breve
bifidobacterium lactis
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blueberry
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bromelain
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butyrate triglyceride
cannabis sativa oil
capsaicinoids
cat's claw
catalase
caterpillar mushroom
chaga mushroom
chamomile
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chlorella
chlorophyll
chokeberry
citrus oil
citrus pectin
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coenzyme Q10 (CoQ10)
colostrum
cordyceps
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cuspidatum root
cyclodextrin
d-alpha tocopherol
d-glucarate
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diallyl disulfide (DADS)
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DPA (docosapentaenoic acid)
eleuthero
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green tea
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HMR lignan
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knotweed
jujube
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Evidence supporting the use of: Folate
For the health condition: Cancer Treatment (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Cancer Treatment (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Cancer Treatment (reducing side effects)