Relationship: Cardiovascular Disease and folate

Evidence supporting the use of: Folate
For the health condition: Cardiovascular Disease

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Source of validity: Scientific
Rating (out of 5): 3

Folate, also known as vitamin B9, has been studied for its role in cardiovascular disease (CVD) prevention and management, primarily due to its ability to reduce homocysteine levels in the blood. Elevated homocysteine is considered a potential risk factor for atherosclerosis and other cardiovascular conditions. Folate functions as a coenzyme in the remethylation of homocysteine to methionine, helping to keep homocysteine levels within a healthy range.

Several large-scale epidemiological studies have observed an association between higher homocysteine levels and increased risk of CVD, leading to the hypothesis that folate supplementation could reduce risk by lowering homocysteine. Randomized controlled trials (RCTs), such as the HOPE-2 and NORVIT trials, have demonstrated that folic acid (with or without B12 and B6) effectively lowers homocysteine concentrations. However, these same trials found little to no effect on reducing cardiovascular events like heart attacks or strokes in populations with established CVD.

Despite the lack of strong evidence for secondary prevention, some meta-analyses suggest a potential modest benefit in primary prevention, particularly in regions with low baseline folate intake and no folic acid food fortification. The evidence is stronger for stroke reduction than for coronary heart disease. Thus, current guidelines generally do not recommend folate supplementation solely for CVD prevention in the general population, but it may be considered in specific contexts. Overall, the scientific justification exists primarily for homocysteine lowering, but translation into reduced cardiovascular events remains uncertain.

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5-methyltetrahydrofolate glucosamine
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
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Algae
algal oil
Algal protein
Allicin
Alliin
Almond fruit
Alpha phytosterol
Alpha-carotene
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
animal Tissue
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocynin
apple
Ardisia
argan nut oil
arginine creatine
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Arginine silicate
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
astaxanthin
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astragalin
astragaloside
astragalus
avocado
baicalin
banana
Basidiomycota
basil
Bassia scoparia
bee products
beet
benfotiamine
berry
beta-hydroxybutyrate
betanin
Bidens pilosa
bilberry
bioflavonoids
bishop\'s weed
black garlic
black ginger
black seed
black tea
blackberry
blueberry
bonito peptide
boysenberry
Brassica
Brazil nut
broccoli
brutieridin
butylphthalide
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caffeic Acid
calamari oil
Calanus finmarchicus
calycosin
camelina oil
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campesterol
capsaicin
capsaicinoids
capsicum
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cashew
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catecholamine
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citrus sinensis (proprietary)
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Evidence supporting the use of: Folate
For the health condition: Cardiovascular Disease

Table of Contents

Synopsis

Other ingredients used for Cardiovascular Disease

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Cardiovascular Disease

Table of Contents

Synopsis

Other ingredients used for Cardiovascular Disease

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Cardiovascular Disease