Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is involved in cardiovascular health primarily through its role in lowering homocysteine levels. Homocysteine is an amino acid in the blood, and elevated levels have been associated with an increased risk of cardiovascular disease (CVD). Vitamin B12, along with folic acid and vitamin B6, is essential for the metabolism of homocysteine to methionine, thereby reducing homocysteine concentrations. Early observational studies suggested a correlation between high homocysteine and greater CVD risk, leading to the hypothesis that B-vitamin supplementation could help reduce risk by lowering homocysteine.

However, randomized controlled trials (RCTs) and meta-analyses have largely failed to show that vitamin B12 supplementation, even when it effectively lowers homocysteine, results in a significant reduction in cardiovascular events such as heart attack or stroke. Notable large-scale studies (e.g., the HOPE-2 trial and others) found that while homocysteine levels dropped, clinical outcomes did not improve appreciably in most populations studied. This suggests that while B12 is mechanistically relevant, the direct impact of supplementation on CVD risk is limited or unproven for most people, especially those without an existing deficiency.

Therefore, the scientific evidence supporting vitamin B12 supplementation for the prevention or treatment of cardiovascular disease is weak (rated 2/5). It may be indicated for individuals with proven B12 deficiency or hyperhomocysteinemia, but routine use for CVD in the general population is not supported by strong evidence.

More about vitamin B12
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Other ingredients used for Cardiovascular Disease

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Products containing vitamin B12

Integrative Therapeutics Active B-Complex
Vitabase Active Man's Formula
Vitabase Active Woman's Multi
Pure Encapsulations Adenosyl/Hydroxy B12
Pure Encapsulations Adenosyl/Hydroxy B12 Liquid
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Thorne Advanced Nutrients Multivitamin
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Douglas Laboratories B-Complex
Vitabase B-Complex 100 mg Sustained Release
Thorne B-Complex #12
Thorne B-Complex #6
Pure Encapsulations B-Complex Plus
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Designs For Health B-Supreme
Designs For Health B-Supreme
Pure Encapsulations B12 5000 liquid
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Pure Encapsulations B12 Liquid
Pure Encapsulations B6 Complex
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Thorne Basic B Complex
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
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Thorne Catalyte
Designs For Health CatecholaCalm™
Metagenics Ceralin® Forte
Vitabase Cholesterol Support
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
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Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
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Designs For Health PaleoMeal®
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Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
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Metagenics UltraClear RENEW Detox Powder Berry
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Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
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Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
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Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
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Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
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Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations VisionPro Nutrients
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Thorne Vitamin B12 Methylcobalamin
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets