Relationship: Circulation (poor) and niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Circulation (poor)

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacinamide (vitamin B3) is chemically related to niacin (nicotinic acid), though their pharmacological effects differ. While niacin is more widely recognized for its vasodilatory properties—producing skin flushing and being used in high doses to improve lipid profiles and peripheral circulation—niacinamide does not cause significant vasodilation at normal supplemental doses. However, both forms are precursors to NAD+ and NADP+, essential coenzymes in cellular metabolism, including pathways that affect vascular health and energy production. The use of niacinamide for circulation is supported by some scientific rationale, mainly extrapolated from studies on niacin. Niacin has demonstrated efficacy in improving peripheral vascular circulation, particularly in conditions like peripheral artery disease (PAD) and intermittent claudication. However, the evidence for niacinamide is less robust. Some small studies and case reports suggest that niacinamide may help in certain microvascular disorders—such as Raynaud's phenomenon or pellagra—where deficiency of vitamin B3 impairs vascular function. In pellagra, vascular symptoms resolve with vitamin B3 supplementation, indicating a role in vascular health when deficiency is present. Overall, while niacinamide might support circulation indirectly by correcting deficiency and supporting endothelial function, its direct vasodilatory effects are minimal compared to niacin. Therefore, scientific evidence supports its use for circulation to a moderate extent (rated 3/5), but it is not the preferred form for addressing poor circulation unless B3 deficiency is implicated.

More about Niacinamide (vitamin B3)
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Other ingredients used for Circulation (poor)

2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acetyl L-carnitine
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Ajoene
algal oil
Allicin
Alliin
Allium tuberosum
alpha-linolenic acid (ALA)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
Angelica
anthocyanidins
anthocyanins
anthocyanosides
antler
Aralia
arginine alpha ketoglutarate
Arginine aspartate
arginine creatine
Arginine nitrate
Arginine silicate
arjun tree
arjuna
arjunic acid
Aronia melanocarpa
ashitaba
ashwagandha
asparagus
astaxanthin
Asteraceae
astragaloside
astragalus
atractylodes
atractylone
Auricularia
Autumn elaeagnus
Bassia scoparia
bee products
beet
bergamot
berry
bilberry
bioflavonoids
biota seed
birch
bishop\'s weed
black cumin
black currant
black galingale
black garlic
black ginger
black pepper
black tea
blackboard tree
blueberry
Boerhavia diffusa
borneol
bromelain
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Buddha\'s hand
bupleurum falcatum
bur-reed
burdock
butcher's broom
Butea monosperma
Caesalpinia crista
caffeine
calycosin
capillary artemisia
capsaicin
capsaicinoids
capsicum
capsinoids
cardamom
carqueja
Carthamus
cat's claw
catecholamine
caterpillar mushroom
cayenne pepper
celery
Centella asiatica
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chen pi
cherry
chestnut
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chocolate
chokeberry
cinnamaldehyde
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cinnamon
cistanche
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citrus bioflavonoids
citrus sinensis (proprietary)
clove
coca
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coenzyme Q10 (CoQ10)
cola nut
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d-alpha tocopherol
danshen
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diallyl sulfide
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lovage
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nicotinamide riboside
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olive
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onion
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paeoniflorin
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peony
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Other health conditions supported by Niacinamide (vitamin B3)

Acne
Age Spots
Alzheimer's Disease
Arthritis
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cholesterol (high)
Circulation (poor)
Dermatitis
Diabetes
Hair (loss or thinning)
Inflammation
Liver Detoxification
Memory and Brain Function
Psoriasis
Wounds and Sores

Products containing Niacinamide (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Circulation (poor)

Table of Contents

Synopsis

Other ingredients used for Circulation (poor)

Other health conditions supported by Niacinamide (vitamin B3)

Products containing Niacinamide (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacinamide (vitamin B3)For the health condition: Circulation (poor)

Table of Contents

Synopsis

Other ingredients used for Circulation (poor)

Other health conditions supported by Niacinamide (vitamin B3)

Products containing Niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Circulation (poor)