Relationship: Circulation (poor) and niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Circulation (poor)

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacinamide (vitamin B3) is chemically related to niacin (nicotinic acid), though their pharmacological effects differ. While niacin is more widely recognized for its vasodilatory properties—producing skin flushing and being used in high doses to improve lipid profiles and peripheral circulation—niacinamide does not cause significant vasodilation at normal supplemental doses. However, both forms are precursors to NAD+ and NADP+, essential coenzymes in cellular metabolism, including pathways that affect vascular health and energy production. The use of niacinamide for circulation is supported by some scientific rationale, mainly extrapolated from studies on niacin. Niacin has demonstrated efficacy in improving peripheral vascular circulation, particularly in conditions like peripheral artery disease (PAD) and intermittent claudication. However, the evidence for niacinamide is less robust. Some small studies and case reports suggest that niacinamide may help in certain microvascular disorders—such as Raynaud's phenomenon or pellagra—where deficiency of vitamin B3 impairs vascular function. In pellagra, vascular symptoms resolve with vitamin B3 supplementation, indicating a role in vascular health when deficiency is present. Overall, while niacinamide might support circulation indirectly by correcting deficiency and supporting endothelial function, its direct vasodilatory effects are minimal compared to niacin. Therefore, scientific evidence supports its use for circulation to a moderate extent (rated 3/5), but it is not the preferred form for addressing poor circulation unless B3 deficiency is implicated.

More about Niacinamide (vitamin B3)
More about Circulation (poor)

Other ingredients used for Circulation (poor)

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black currant
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blueberry
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Other health conditions supported by Niacinamide (vitamin B3)

Acne
Age Spots
Alzheimer's Disease
Arthritis
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cholesterol (high)
Circulation (poor)
Dermatitis
Diabetes
Hair (loss or thinning)
Inflammation
Liver Detoxification
Memory and Brain Function
Psoriasis
Wounds and Sores

Products containing Niacinamide (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Circulation (poor)

Table of Contents

Synopsis

Other ingredients used for Circulation (poor)

Other health conditions supported by Niacinamide (vitamin B3)

Products containing Niacinamide (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacinamide (vitamin B3)For the health condition: Circulation (poor)

Table of Contents

Synopsis

Other ingredients used for Circulation (poor)

Other health conditions supported by Niacinamide (vitamin B3)

Products containing Niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Circulation (poor)