Relationship: Depression and vitamin B12

Evidence supporting the use of: Vitamin B12
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is scientifically recognized as an important nutrient for brain health and neurological function, and its deficiency has been associated with neuropsychiatric symptoms, including depression. Several observational studies suggest that individuals with low serum B12 levels may have a higher risk of developing depressive symptoms. The proposed mechanisms include B12's role in methylation processes, neurotransmitter synthesis (such as serotonin and dopamine), and homocysteine metabolism—all factors implicated in mood regulation. However, the evidence for B12 supplementation as a treatment for depression in those with normal B12 levels is limited. Randomized controlled trials (RCTs) and systematic reviews generally find that while B12 supplementation may improve mood and reduce depressive symptoms in people who are B12-deficient, it does not appear to have a significant effect in those with adequate levels. For example, a 2013 systematic review concluded that B-vitamin supplementation could benefit people with depression who are deficient, but the effect size is modest and not universal. Current clinical guidelines recommend checking B12 status in patients presenting with depressive symptoms, especially in older adults or those with risk factors for deficiency. Supplementation is indicated when deficiency is identified, as this may alleviate depressive symptoms and prevent further neurological decline. In summary, there is some scientific basis for the use of vitamin B12 in depression, but primarily as correction of deficiency rather than as a direct antidepressant.

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alpha-linolenic acid (ALA)
amino acids
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basil
bergamot
beta caryophyllene
Bifidobacterium longum
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chamomile
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clove
coenzyme Q10 (CoQ10)
cordyceps
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damiana
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DPA (docosapentaenoic acid)
eleuthero
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flavonols
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Evidence supporting the use of: Vitamin B12
For the health condition: Depression

Table of Contents

Synopsis

Other ingredients used for Depression

Other health conditions supported by vitamin B12

Products containing vitamin B12

Health Concerns

Brands

Evidence supporting the use of: Vitamin B12For the health condition: Depression

Table of Contents

Synopsis

Other ingredients used for Depression

Other health conditions supported by vitamin B12

Products containing vitamin B12

Evidence supporting the use of: Vitamin B12
For the health condition: Depression