Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is supported by some scientific evidence for its role in supporting or treating depression, though the evidence is not robust. Vitamin B6 is a coenzyme involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play important roles in mood regulation. Several observational studies have found associations between low B6 status and an increased risk of depressive symptoms. For example, some research suggests that individuals with depression may have lower levels of B6 compared to healthy controls. Randomized controlled trials (RCTs) evaluating B6 supplementation alone for depression are limited and have shown mixed results, with some small studies reporting modest improvements, particularly in specific populations (such as premenstrual women or the elderly), while others find no significant benefit. B6 is often studied in combination with other B vitamins (such as folate and B12), making it difficult to isolate its independent effects. Professional guidelines do not currently recommend B6 supplementation as a primary treatment for depression, but clinicians may consider correcting deficiencies as part of a broader strategy. In summary, while there is some scientific rationale and preliminary evidence for vitamin B6 in managing depression, the overall quality and quantity of evidence is limited, and more high-quality RCTs are needed to establish its efficacy.

More about vitamin B6
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Other ingredients used for Depression

Other health conditions supported by vitamin B6

Products containing vitamin B6

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