Relationship: Dermatitis and niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Dermatitis

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Source of validity: Scientific
Rating (out of 5): 3

Synopsis of Evidence Supporting Niacinamide (Vitamin B3) for Dermatitis

Niacinamide (nicotinamide), a form of vitamin B3, has gained increasing attention for its potential therapeutic role in various dermatological conditions, including dermatitis. Scientific evidence, particularly from clinical studies, supports its use primarily in atopic dermatitis and other inflammatory skin conditions.

Niacinamide possesses anti-inflammatory, barrier-strengthening, and immunomodulatory properties. Its topical application has been shown to enhance the synthesis of ceramides, free fatty acids, and cholesterol, which are crucial for maintaining the skin's barrier function. A compromised skin barrier is a hallmark of dermatitis, especially atopic dermatitis, leading to increased transepidermal water loss and susceptibility to irritants and allergens.

Several randomized controlled trials have demonstrated that topical niacinamide can reduce inflammation, erythema, and transepidermal water loss in patients with atopic dermatitis and other eczematous conditions. For example, a double-blind study published in the International Journal of Dermatology showed that a 5% niacinamide cream was effective in improving the skin barrier and reducing symptoms in patients with atopic dermatitis, with efficacy comparable to some standard treatments such as topical steroids or calcineurin inhibitors.

Oral niacinamide is less commonly used for dermatitis but is well-recognized for preventing pellagra, a disease caused by niacin deficiency that features dermatitis among its primary symptoms. Overall, while the evidence base is moderate and further large-scale studies are warranted, current data justify the use of niacinamide as a supportive treatment for certain types of dermatitis.

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Other ingredients used for Dermatitis

aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
lactoperoxidase
lauric acid
niacinamide (vitamin B3)
oregon grape
phenolic acids
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
vitamin A
vitamin D
vitamin E
zinc
chickweed
xanthium (cockleburs)
mugwort
neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
menthol oil
melaleuca alternifolia
geranium
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Bee Propolis
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Bidens pilosa
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Boswellic Acid
Butea monosperma
Barleria
Bisabolene
Bee products
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Bassia scoparia
Coconut
Centella triterpenes
Caryophyllene
Calendula
Chlorophyllin
coconut oil
Colloid
Carvacrol
Curcuminoid
Chinese Raisintree
Curcumen
Centella asiatica
Centipeda
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Carthamus
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fibroblast growth factor
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Other health conditions supported by niacinamide (vitamin B3)

Acne
Age Spots
Alzheimer's Disease
Arthritis
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cholesterol (high)
Circulation (poor)
Dermatitis
Diabetes
Hair (loss or thinning)
Inflammation
Liver Detoxification
Memory and Brain Function
Psoriasis
Wounds and Sores

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Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Dermatitis

Table of Contents

Synopsis

Synopsis of Evidence Supporting Niacinamide (Vitamin B3) for Dermatitis

Other ingredients used for Dermatitis

Other health conditions supported by niacinamide (vitamin B3)

Products containing niacinamide (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacinamide (vitamin B3)For the health condition: Dermatitis

Table of Contents

Synopsis

Synopsis of Evidence Supporting Niacinamide (Vitamin B3) for Dermatitis

Other ingredients used for Dermatitis

Other health conditions supported by niacinamide (vitamin B3)

Products containing niacinamide (vitamin B3)

Evidence supporting the use of: Niacinamide (vitamin B3)
For the health condition: Dermatitis