Relationship: Fatigue and folate

Evidence supporting the use of: Folate
For the health condition: Fatigue

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) is scientifically recognized as essential for numerous metabolic processes, particularly in DNA synthesis and the production of red blood cells. Folate deficiency is well-established as a cause of megaloblastic anemia—a condition characterized by the production of abnormally large red blood cells that are inefficient at transporting oxygen. One of the primary symptoms of this type of anemia is fatigue, as tissues and organs receive less oxygen than needed. Supplementation with folate is a validated treatment for correcting folate-deficiency anemia, which in turn alleviates associated fatigue. However, the evidence supporting the use of folate to treat fatigue in individuals with normal folate levels is much weaker. Most clinical studies indicate that folate supplementation does not improve fatigue unless there is a documented deficiency. In healthy populations, fatigue has multifactorial causes, and supplementation with folate does not appear to provide significant benefit unless there is an underlying deficiency or increased requirement (e.g., pregnancy). In summary, folate is scientifically validated for the treatment of fatigue specifically when caused by folate-deficiency anemia, but not as a general remedy for fatigue in individuals with adequate folate status. Therefore, folate’s use for fatigue is best targeted at those with proven deficiency, and indiscriminate supplementation for fatigue is not supported by current research.

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Other ingredients used for Fatigue

1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Acai berry
Acetyl L-carnitine
Acetyl-L-Tyrosine
Achyranthes
Adenophora
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
adrenal cortex
Adzuki bean
Agarwood
Agrimonia pilosa
AHCC
Akebia
Albizia
Aletris
Alfalfa
Algae
Algal protein
Allium tuberosum
Almond fruit
Alpha D-ribofuranose
Alpha lactalbumin
Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amaranth
amber
American Liverleaf
amino acids
Amor seco
anamu
anemarrhena asphodeloides
Angelica
animal protein
anthocyanins
antler
Antrodia camphorata
apple
apple cider vinegar
Aralia
Ardisia
Areca
Arginine aspartate
arginine creatine
Arginine malate
Arginine orotate
Arisaema
arjun tree
arjuna
arjunic acid
Armillaria mellea
ashitaba
ashwagandha
asparagus
aspartic acid
astaxanthin
aster root
astragaloside
astragalus
atractylodes
atractylone
Autumn Olive
avens
ba ji tian
baccosides
bacoside
bacteria
baicalin
banana
baobab
barley
Basidiomycota
Bassia scoparia
Bauhinia
BCAA
bee pollen
beef
Beef liver
beet
bergamot
beta-alanine
beta-hydroxybutyrate
betel
betony
Bifidobacterium breve
big quaking grass
bignay
biota seed
bird\'s nest
black cumin
black garlic
black ginger
black gram
black salt
black seed
black tea
Blepharis
Blue-Green Alage
Boerhavia diffusa
bone marrow
bonito peptide
Borassus aethiopum
borassus palm
borneol
bottle gourd
bovine heart
bovine kidney
bovine liver
bovine spleen
brahmi
branched-chain amino acids
breadnut
Broussonetia
Bupleurum
bupleurum falcatum
burdock
C-phycocyanin
cactus
caffeine
California chia
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Canscora
cardamom
Carthamus
cat's claw
catalpol
caterpillar mushroom
catuaba
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cereal grass
Cereus
chaga mushroom
chanterelle
chard
chen pi
chestnut
chia seed
chia seed
Chinese fleeceflower
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Chinese salvia root
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cistanche
citrus sinensis (proprietary)
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cocarboxylase
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coenzyme Q10 (CoQ10)
coffee fruit
cola nut
cordyceps
coriolus mushroom
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costus
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creatine
creatine monohydrate
cumin
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curry leaf
cyanobacteria
Cyanotis vaga
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Cymbopogon martini
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D-Ribose
damiana
date
deer root
deer velvet
Dendrobium
devil\'s club
dextrose
DHEA
DHEA (dehydroepiandrosterone)
dibenzo-alpha pyrones
dioscorea
DMPX
dodder
dodeca-2E, 4E-dienoic acid isobutylamide
Dolichos
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dragon fruit
dragonhead
duckweed
dulse
dulse leaf
durian
ecdysteroids
Ecklonia
electrolytes blend (proprietary)
eleuthero
elk antler
Embelia
emblicanin
enokitake
Ephedra
ephedrine
ergothioneine
eriocitrin
Erodium cicutarium
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Ethyl-Alpha-Guanido-Methyl-Ethanoate
Euglena gracilis
Eupolyphaga sinensis
European five-finger grass
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Euryale seed
Eurycoma Longifolia
eurycomanone
fatty acids
fennel
fenugreek
fenuside
finger-leaf morning glory
fish
fish protein
Flammulina velutipes
flat-stem milk-vetch
flavin mononucleotide
Flemingia philippinensis
fo-ti
folate
folic acid
Foxtail millet
fruit and vegetable blend (proprietary)
fu ling
fulvic acid
fungus
furostanols
gamma-glutamylcysteine
ganoderma
garden cress
gastrodia
Gentianella alborosea
Gerovital H3
giant blazingstar
ginseng
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Glechoma hederacea
glucose
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gooseberry
gotu kola
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guanidinoacetic acid
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hericium mushroom
hibiscus
hijiki
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Himalayan salt
honeybush
horny goat weed
horse gram
Horsemint
hydroxymethylbutyrate
Hygrophila
hypsizygus marmoreus
icariin
Ilex
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Indian sarsparilla
Indian tinospora
iridoid glycosides
iridoids
iron
isomaltulose
Jaboticaba
Japanese kadsura
Jatoba
jiaogulan
joe-pye
jujube
Kefir
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ketosterones
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knotweed
Kokam
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l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
l-carnitine
L-cysteine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
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lactiplantibacillus plantarum
Lactoferrin
Legume protein
lemon balm
Lentinula edodes mycelia
Leptadenia
ligustilides
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Lindera
lingzhi
lion's mane
liquid liver fractions
little ironweed
longan
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lotus seed
lucuma
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maral root
Marine lipid
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Matcha
Mate
Melatonin
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Methylxanthine
Milk
Milk Protein
millet seed
Mimosa
Ming Dang Shen
Mistletoe
Molasses
Momordica
Morinda
Moringa
Morus
Mountain pride
Muira puama
Mulberry
Mung bean
Mushroom
NADH
Nardostachys
Natsudaidai
Nettle
nicotinamide riboside
noni
nopal
nut grass
oat
okra
omega-3 fatty acids
Onosma bracteatum
oolong tea
Ophiopogon
ophiopogon root
orange
orchid
Orchis latifolia
Ornithine
ornithine alpha-ketoglutarate
ornithine L-aspartic acid
Oroxylum indicum
oryza
Osmanthus
oxaloacetic acid
Oxindole alkaloids
Oxypregnane glycoside
oyster mushroom
paeoniflorin
Palatinose
pantothenic acid (vitamin B5)
paraxanthine
parsley
Passionfruit
Pentacyclic triterpenoids
Pentatropis capensis
peony
Pepper
Peppermint
Peptides
Persimmon
Phaeophyceae
phellodendron amurense
Phosphocreatine
Phyllanthus
Physalis angulata
Phytoecdysteroid
Piper nigrum
Plankton
Pleurotus eryngii
plum fruit
pollen
polygala root
Polygonatum
Polygonum
polyporous mushroom
polysaccharides
pomegranate
Portulaca
potassium
prebiotic blend (proprietary)
Prickly Pear Cactus
Propionyl-L-Carnitine
protein
prune
Pseudostellaria
Puerain
punarnava
purslane
Pycnogenol
pyrroloquinoline disodium salt
pyrroloquinoline quinone
pyruvate
quail egg
quercetin
quinoa
Quinoa Protein
Rehmannia
rehmannia glutinosa
reishi mushroom
relora® (proprietary)
Rhaponticum
Rhodiola
Rhodymenia
riboflavin (vitamin B2)
ribose
rice
robusta coffee
rockweed
Rooibos
root tuber
Rosa roxburghii
Rosabin
rosavins
rosemary
royal jelly
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
Rubus
Safed musli
Salidroside
Salvia
saponins
Sarivan
sarsaparilla
Scabrous Gentian
Schisandrins
Schizandrol A
scrophularia root
sea salt
seaweed
Selaginella
Semecarpus anacardium
sesame
Sete sangrias
Shark Liver Oil
Shataverins
shiitake mushroom
Shilajit
Sichuan Lovage
Sida cordifolia
silk tree
Silkmoth
smilax
Sophora
soursop
Spanish Needle
Spantholobus
Spelt
Spikenard
spinach
spirulina
spruce
Sulbutiamine
suma
Sumac
Sweet Bay
Sweet Orange alcohol
Sword Bean
Tamarind
Tea
Teacrine
Tejocote
Terminalia
Theacrine
Thiamin (vitamin B1)
thyroid substance
Tiger Nut
Tinospora cordifolia
Tongkat ali
trace minerals
Trametes
Tremella
Trichilia catigua
Trichopus zeylanicus
Trimethylglycine (TMG)
Triphala
Turkey tail mushroom
turmeric
Turtle Head
ubiquinol
Uncaria
Urolithin A
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
Vegetable Protein
velvet bean
Vetiver
Vine tea
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
Water Pepper
Watercress
Waterhyssop
Watermelon
Wax Gourd
Wheat
wheat germ
wheat grass
Whey protein
White Tea
whole adrenal glandular
Winter Begonia
Withanolides
Wood betony
Wulinshen
Xanthine
Xanthone
Xanthophyll
Xylaria nigripes
Yeast
Yerba buena
Yerba mate
Yohimbine
Yuzu
Zapilopatle Bean
Zedoary
Zucchini
β-nicotinamide mononucleotide (NMN)

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: Folate
For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Fatigue