Relationship: Fatigue and folate

Evidence supporting the use of: Folate
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) is scientifically recognized as essential for numerous metabolic processes, particularly in DNA synthesis and the production of red blood cells. Folate deficiency is well-established as a cause of megaloblastic anemia—a condition characterized by the production of abnormally large red blood cells that are inefficient at transporting oxygen. One of the primary symptoms of this type of anemia is fatigue, as tissues and organs receive less oxygen than needed. Supplementation with folate is a validated treatment for correcting folate-deficiency anemia, which in turn alleviates associated fatigue. However, the evidence supporting the use of folate to treat fatigue in individuals with normal folate levels is much weaker. Most clinical studies indicate that folate supplementation does not improve fatigue unless there is a documented deficiency. In healthy populations, fatigue has multifactorial causes, and supplementation with folate does not appear to provide significant benefit unless there is an underlying deficiency or increased requirement (e.g., pregnancy). In summary, folate is scientifically validated for the treatment of fatigue specifically when caused by folate-deficiency anemia, but not as a general remedy for fatigue in individuals with adequate folate status. Therefore, folate’s use for fatigue is best targeted at those with proven deficiency, and indiscriminate supplementation for fatigue is not supported by current research.

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bupleurum falcatum
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citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
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Products containing folate

Health Concerns

Brands

Evidence supporting the use of: Folate
For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Fatigue