Relationship: Fatigue and pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Fatigue

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Synopsis
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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Pantothenic acid (vitamin B5) is traditionally used as a remedy for fatigue, largely based on its fundamental role in energy metabolism. As a component of coenzyme A, pantothenic acid is essential for the synthesis and oxidation of fatty acids, as well as the metabolism of carbohydrates and proteins—processes central to cellular energy production. Historically, some practitioners and supplement manufacturers have promoted pantothenic acid for combating general tiredness and supporting adrenal "health" under the assumption that it helps the body cope with physical and mental stress. This idea was partly influenced by early animal studies in the mid-20th century indicating that deficiency led to symptoms such as fatigue, irritability, and malaise. However, scientific validation for the use of pantothenic acid supplementation to alleviate fatigue in otherwise healthy individuals is lacking. While deficiency can cause symptoms of fatigue, true pantothenic acid deficiency is extremely rare due to its wide availability in foods. Clinical studies specifically evaluating supplemental pantothenic acid for fatigue in non-deficient populations are nearly absent, and systematic reviews do not support its use for this purpose. Current guidelines do not recommend pantothenic acid as a treatment for fatigue except in the context of laboratory-confirmed deficiency. Thus, while the traditional rationale is rooted in its biochemical role, robust clinical evidence is limited.

More about pantothenic acid (vitamin B5)
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Other health conditions supported by pantothenic acid (vitamin B5)

Acne
Adrenal Fatigue
Burning Feet or Hands
Energy (lack of)
Fatigue
Hair (loss or thinning)

Products containing pantothenic acid (vitamin B5)

Health Concerns

Brands

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

Health Concerns

Brands

Evidence supporting the use of: Pantothenic acid (vitamin B5)For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by pantothenic acid (vitamin B5)

Products containing pantothenic acid (vitamin B5)

Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the health condition: Fatigue