Relationship: Fatigue and riboflavin (vitamin B2)

Evidence supporting the use of: Riboflavin (vitamin B2)
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Riboflavin (vitamin B2) is an essential water-soluble vitamin that plays a critical role in cellular energy production, mainly as a precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These cofactors are crucial for oxidative phosphorylation in mitochondria and for the metabolism of carbohydrates, fats, and proteins into usable cellular energy (ATP). Deficiency in riboflavin can cause symptoms such as fatigue, weakness, and anemia due to impaired energy production.

However, scientific evidence for the use of riboflavin supplementation to treat or reduce fatigue in the general population (i.e., in those without a diagnosed deficiency) is limited. Most controlled studies demonstrating benefit are in the context of riboflavin deficiency, where supplementation clearly alleviates fatigue and related symptoms. For otherwise healthy individuals, there is little robust evidence that additional riboflavin improves energy levels or reduces fatigue.

Some studies have investigated riboflavin in specific populations (e.g., individuals with migraine or chronic fatigue syndromes), but results are mixed and often confounded by other variables. Thus, while the biological plausibility is strong in deficiency states, scientific validation for use in treating general fatigue is modest, reflected in the evidence rating of 2/5. Riboflavin supplementation is justified to treat fatigue only in cases of deficiency, not as a general energy booster.

More about riboflavin (vitamin B2)
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Other health conditions supported by riboflavin (vitamin B2)

Anemia
Cataracts
Dermatitis
Fatigue
Headache (general)
Headache (tension)
Inflammation
Migraine
Seborrhea

Products containing riboflavin (vitamin B2)

Health Concerns

Brands

Evidence supporting the use of: Riboflavin (vitamin B2)
For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by riboflavin (vitamin B2)

Products containing riboflavin (vitamin B2)

Health Concerns

Brands

Evidence supporting the use of: Riboflavin (vitamin B2)For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by riboflavin (vitamin B2)

Products containing riboflavin (vitamin B2)

Evidence supporting the use of: Riboflavin (vitamin B2)
For the health condition: Fatigue