Relationship: Fatigue and thiamin (vitamin B1)

Evidence supporting the use of: Thiamin (vitamin B1)
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Thiamin (vitamin B1) has a scientifically established role in energy metabolism, as it is an essential coenzyme in carbohydrate metabolism and plays a crucial part in mitochondrial energy production. Thiamin deficiency leads to conditions such as beriberi and Wernicke-Korsakoff syndrome, both of which are characterized by symptoms that include profound fatigue, muscle weakness, and neurological disturbances. Supplementation with thiamin in deficient individuals has been shown to reverse these symptoms, providing clear scientific support for its use in treating fatigue specifically resulting from deficiency.

However, the evidence for using thiamin supplementation to treat fatigue in the general population—where deficiency is not present—is significantly weaker. Few high-quality clinical trials demonstrate benefits for fatigue in otherwise healthy or non-deficient individuals. Most studies focus on populations at risk of deficiency (such as those with malnutrition, chronic alcoholism, or certain chronic illnesses). In these groups, correcting thiamin deficiency can improve fatigue, but this does not translate to a general recommendation for thiamin supplementation to treat nonspecific fatigue in healthy populations.

In summary, the use of thiamin to support fatigue is scientifically justified, but primarily in cases of deficiency. Evidence does not support its routine use for fatigue in those with adequate thiamin status. The overall evidence rating is therefore modest, reflecting clear benefit in deficiency but limited data for broader applications.

More about thiamin (vitamin B1)
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Other health conditions supported by thiamin (vitamin B1)

Alcoholism
Burning Feet or Hands
Congestive Heart Failure
Diabetes
Fatigue
Nerve Damage
Nervous Exhaustion
Peripheral Neuropathy

Products containing thiamin (vitamin B1)

Health Concerns

Brands

Evidence supporting the use of: Thiamin (vitamin B1)
For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by thiamin (vitamin B1)

Products containing thiamin (vitamin B1)

Health Concerns

Brands

Evidence supporting the use of: Thiamin (vitamin B1)For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by thiamin (vitamin B1)

Products containing thiamin (vitamin B1)

Evidence supporting the use of: Thiamin (vitamin B1)
For the health condition: Fatigue