Evidence supporting the use of: Vitamin B12
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 is scientifically recognized as essential for normal energy production and neurological function. Fatigue is a classic symptom of vitamin B12 deficiency, which can result from inadequate dietary intake (especially in strict vegetarians/vegans), malabsorption syndromes (e.g., pernicious anemia), or certain medical conditions affecting the digestive tract. Numerous clinical studies have demonstrated that correcting vitamin B12 deficiency in affected individuals leads to significant improvements in fatigue and related symptoms. For example, a 2006 study in the "Journal of the American Geriatrics Society" showed that B12 supplementation improved fatigue and cognitive symptoms in deficient elderly patients. However, in people with normal B12 status, robust evidence does not support the use of additional B12 supplementation for fatigue. Several studies in healthy or non-deficient individuals found no benefit of B12 supplementation on energy levels or fatigue. Thus, the scientific justification for B12 in the treatment of fatigue is strong, but primarily limited to cases of confirmed deficiency. Routine supplementation in the absence of deficiency is not supported by current evidence. In summary, vitamin B12 is an effective treatment for fatigue due to deficiency, but does not alleviate fatigue from other causes.

More about vitamin B12
More about Fatigue

Other ingredients used for Fatigue

acai berry
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
adrenal cortex
alfalfa
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
apple
arjun tree
ashwagandha
asparagus
aspartic acid
astaxanthin
astragalus
waterhyssop
barley
beet
bergamot
berry flavor
beta-alanine
betel
bifidobacterium breve
black cumin
black garlic
sesame
black tea
bonito peptide
Indian frankincense
bovine heart
bovine kidney
bovine liver
bovine spleen
branched-chain amino acids
rice
bupleurum falcatum
burdock
caffeine
cat's claw
caterpillar mushroom
chaga mushroom
chen pi
chia seed
Chinese salvia root
chlorella
chokeberry
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
damiana
DHEA (dehydroepiandrosterone)
eleuthero
fennel
fenugreek
fish protein
folate
fruit and vegetable blend (proprietary)
fu ling
ginseng
gooseberry
gotu kola
greek mountain tea
green tea
guarana
guayusa
hibiscus
Indian tinospora
iron
knotweed
jujube
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-alanyl-l-glutamine
l-carnitine
l-cysteine
l-glycine
l-leucine
l-ornithine
l-taurine
l-tyrosine
l-valine
lactiplantibacillus plantarum
lactoferrin
lentinula edodes mycelia
lion's mane
liquid liver fractions
lychee
maca
magnesium
maitake mushroom
malic acid
maltodextrin
mango
mangosteen
marine lipid
matcha
melatonin
milk
moringa
muira puama
Acetyl-L-Tyrosine
nettle
nicotinamide riboside
spruce
oat
okra
omega-3 fatty acids
ophiopogon root
orange
ornithine alpha-ketoglutarate
oyster mushroom
pantothenic acid (vitamin B5)
parsley
peppermint oil
phellodendron amurense
plum fruit
pollen
polygala root
pomegranate
potassium
prebiotic blend (proprietary)
protein
prune
pyrroloquinoline disodium salt
quail egg
quercetin
quinoa
redcurrant
rehmannia glutinosa
reishi mushroom
relora® (proprietary)
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
scrophularia root
shiitake mushroom
black ginger
spinach
spirulina
thiamin (vitamin B1)
tongkat ali
trimethylglycine (TMG)
triphala
almond fruit
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
seaweed
watercress
watermelon
wheat grass
whey protein
mulberry
whole adrenal glandular
yeast
β-nicotinamide mononucleotide (NMN)
sarsaparilla
suma
jiaogulan
oryza
tangerine
gastrodia
cardamom
atractylodes
nut grass
punarnava
smilax
tinospora cordifolia
rubia cordifolia
bee pollen
peony
lingzhi
morus
root tuber
silk tree
haliotis
amber
cistanche
dioscorea
dodder
ganoderma
lotus seed
morinda
electrolytes blend (proprietary)
dulse leaf
royal jelly
trace minerals
anemarrhena asphodeloides
purslane
fulvic acid
aster root
yerba mate
wheat germ
noni
wood betony
biota seed
nopal
goji berry
amaranth
millet seed
algae
cocoa
thyroid substance
ashitaba
soursop
sea salt
DMPX
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Aralia
Avens
Arjuna
akebia
Apple Cider Vinegar
Alpha polylactate
Antler
Arginine Creatine
Ardisia
Angelica
Antrodia camphorata
Arginine malate
Arginine aspartate
Achyranthes
Anamu
Autumn Olive
Albizia
Arginine orotate
AHCC
Aletris
Adrafinil
Agarwood
American Liverleaf
Alpha-Lipoic Acid
Astragaloside
Armillaria mellea
Alpha lactalbumin
Areca
Adzuki bean
Agrimonia pilosa
adenosine triphosphate (ATP)
Algal protein
Arjunic Acid
Adenophora
Allium tuberosum
Amor seco
Arisaema
Atractylone
Animal protein
Betony
Black Seed
Broussonetia
Beta-hydroxybutyrate
Breadnut
Blepharis
Beef
Beef liver
Big Quaking Grass
Bone Marrow
Baccosides
Basidiomycota
Black Gram
Bauhinia
Brahmi
Ba Ji Tian
black salt
Borassus Palm
Borassus aethiopum
Bacteria
Blue-Green Alage
banana
Baobab
BCAA
Bupleurum
bacoside
Baicalin
Bassia scoparia
Bignay
Boerhavia diffusa
Bottle gourd
Borneol
Bird's nest
Chia seed
Cumin
Camellia sinensis
Coconut
Centella triterpenes
Chinese Silkvine
Curry leaf
Cowpea
California chia
Cinnamomum
Clary sage
Cocarboxylase
Chinese Mountain Ant
Cyanobacteria
Catalpol
Coriolus mushroom
Codonopsis
Cactus
Cynomorium
Cyathula
Chinese Fleeceflower
Chinese Pond Turtle
Cereal grass
Chlorophytum
Chuchuhuasi
Cyclanthera pedata
Curcumen
Cymbopogon Martini
Cyanotis Vaga
Centella asiatica
Coca
Coconut Water
Chocolate
Chard
Chinese Ligustrum berry
Creatine
Chicken
Corktree
Chanterelle
Catuaba
C-Phycocyanin
Chondracanthus chamissoi
Chestnut
Costus
Cereus
Carthamus
cola nut
Canscora
Currant
Chondrus
DHEA
Dendrobium
Deer Root
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dragon Fruit
Durian
Deer Velvet
Dong Quai
Dibenzo-alpha pyrones
Dragonhead
Devil's Club
Dolichos
Date
Dulse
D-Ribose
Dextrose
Duckweed
Ephedra
Erythropalum scandens
Eriocitrin
Eupolyphaga sinensis
Erodium cicutarium
Euryale seed
Ergothioneine
Elk antler
Emblicanin
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Euglena gracilis
Ephedrine
European-Five Finger Grass
European Hornbeam
Embelia
Ecklonia
Enokitake
Folic Acid
Finger-Leaf Morning Glory
Flammulina velutipes
glucose
Himalayan Salt
Ketone Salts
Lotus
Little ironweed
Molasses
Milk Protein
Mistletoe
Mimosa
Orchid
Prickly Pear Cactus
Quinoa Protein
Spikenard
Sumac
Sweet Orange alcohol
Wheat
yohimbine
Zucchini

Products containing vitamin B12

Integrative Therapeutics Active B-Complex
Vitabase Active Man's Formula
Vitabase Active Woman's Multi
Pure Encapsulations Adenosyl/Hydroxy B12
Pure Encapsulations Adenosyl/Hydroxy B12 Liquid
Metagenics AdvaClear
Metagenics AdvaClear
Thorne Advanced Bone Support Oscap
Thorne Advanced Nutrients Multivitamin
Pure Encapsulations Amino-NR
Metagenics Axis Endo™ Mango
Douglas Laboratories B-Complex
Vitabase B-Complex 100 mg Sustained Release
Thorne B-Complex #12
Thorne B-Complex #6
Pure Encapsulations B-Complex Plus
Pure Encapsulations B-Complex Plus
Designs For Health B-Supreme
Designs For Health B-Supreme
Pure Encapsulations B12 5000 liquid
Integrative Therapeutics B12-Active
Pure Encapsulations B12 Folate
Pure Encapsulations B12 Liquid
Pure Encapsulations B6 Complex
Pure Encapsulations B6 Complex
Thorne Basic B Complex
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Metagenics Blisphora®
Thorne Catalyte
Designs For Health CatecholaCalm™
Metagenics Ceralin® Forte
Vitabase Cholesterol Support
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change Daily Essentials
Integrative Therapeutics Clinical Nutrients HP
Designs For Health CraveArrest™
Thorne Craving and Stress Support Relora Plus
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health DFH Complete Multi™ with Copper & Iron
Vitabase Easy Iron
Pure Encapsulations Energize Plus™ Pure Pack
Metagenics EstroFactors®
Metagenics Fem Prenatal®
Designs For Health FemGuard+Balance™
Thorne Ferrasorb
Pure Encapsulations Folate 5,000 Plus
Metagenics GI Sustain™ Powder
Metagenics Glutagenics
Integrative Therapeutics Glycemic Manager
Metagenics Glycogenics
Vitabase Hair, Skin & Nails Formula
Metagenics Hemagenics
Metagenics Hemagenics
Metagenics HerSynergy®
Pure Encapsulations Homocysteine Factors
Pure Encapsulations Homocysteine Factors
Designs For Health Homocysteine Supreme™
Designs For Health Homocysteine Supreme™
Metagenics Intrinsi B-12 Folate
Metagenics Intrinsi B12-Folate
Integrative Therapeutics Iron Complex
Integrative Therapeutics K-PAX MitoNutrients
Metagenics Ketogenic Shake Chocolate
Metagenics Ketogenic Shake Vanilla
Klean Athlete Klean B-Complex
Klean Athlete Klean Multivitamin ™
Vitabase Life's Essentials Plus
Metagenics Lipo-Gen™
Metagenics Lipo-Gen
Designs For Health Liposomal B Supreme
Integrative Therapeutics Lipotropic Complex
Pure Encapsulations Lipotropic Detox
Pure Encapsulations Liquid B-Complex
Douglas Laboratories Liquid B12
Integrative Therapeutics Liquid Iron
Designs For Health Lithium Synergy
Designs For Health LV-GB Complex™
Thorne MediClear Plus
Thorne Men's Multi 50+
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaGlycemX™
Metagenics MetaGlycemX
Metagenics MetaKids Multi Soft Chew Grape
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Metagenics MetaRelax®
Douglas Laboratories Methyl B12 Plus
Thorne Methyl-Guard
Thorne Methyl-Guard Plus
Pure Encapsulations MethylAssist
Metagenics MethylCare
Pure Encapsulations Methylcobalamin 1,000 mcg
Pure Encapsulations Methylcobalamin 1,000 mcg
Designs For Health Mitochondrial NRG™
Metagenics MitoVive
Designs For Health Mood-Stasis™
Pure Encapsulations Multi t/d
Pure Encapsulations Multi t/d
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Metagenics Multigenics®
Metagenics Multigenics Chewable Orange
Metagenics Multigenics Intensive Care
Metagenics Multigenics Intensive Care without Iron
Metagenics Multigenics without Iron
Integrative Therapeutics Multiplex-1 No-Iron
Designs For Health NeuroCalm™
Pure Encapsulations NeuroMood Pure Pack
Designs For Health NeuroRenew™
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950® A without Copper & Iron
Pure Encapsulations Nutrient 950® with NAC
Pure Encapsulations Nutrient 950® with Vitamin K
Pure Encapsulations Nutrient 950® without Copper, Iron & Iodine
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations Nutrient 950® without Iron
Integrative Therapeutics Nutrivitamin No-Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Designs For Health OcuForce™
Integrative Therapeutics Osteoprime Forte
Integrative Therapeutics Osteoprime Ultra
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health PaleoMeal®
Designs For Health PaleoMeal®
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
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Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse
Designs For Health Plant Protein Cleanse Plus™ 570g
Designs For Health Plant Protein Meal
Designs For Health Plant Protein Meal Plus
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Metagenics PlusOne® Daily Prenatal Packs
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Integrative Therapeutics ProThrivers Multivitamin
Pure Encapsulations PureGenomics® B-Complex
Pure Encapsulations PureGenomics® Multivitamin
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureLean® Protein
Pure Encapsulations PureMelt B12 Folate
Pure Encapsulations PurePals
Pure Encapsulations PurePals with Iron
Pure Encapsulations PureResponse™ Multivitamin
Douglas Laboratories Relora ®-Plex
Metagenics Renagen™ DTX
Pure Encapsulations RevitalAge™ Nerve
Designs For Health SAMe
Designs For Health SAMe
Metagenics SeroSyn
Thorne Stress B-Complex
Douglas Laboratories Stress-B-Plus ™
Designs For Health Super Liquid Folate
Vitabase Super Stress Formula
Metagenics Testralin®
Thorne Thyrocsin
Designs For Health Tricobalamin™ lozenges
Designs For Health Trifolamin™ lozenges
Designs For Health Twice Daily Essential Packets
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Douglas Laboratories Ultra B-Complex
Pure Encapsulations Ultra B-Complex with PQQ
Designs For Health Ultra B12-Folate
Metagenics Ultra Glucose Control® Chocolate
Metagenics Ultra Glucose Control Chocolate
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Glucose Control Vanilla
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ® 2 Daily
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Douglas Laboratories Ultra Protein Green
Pure Encapsulations Ultra Pure Pack
Metagenics UltraClear Detox Powder
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations VisionPro Nutrients
Designs For Health Vitamin B12 Lozenges
Thorne Vitamin B12 Methylcobalamin
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets