Relationship: Fatigue and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Fatigue

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is essential for numerous enzymatic reactions in the body, particularly those involved in amino acid metabolism, neurotransmitter synthesis, and energy production. Fatigue can be a symptom of vitamin B6 deficiency, and supplementation is effective in reversing fatigue caused specifically by a deficiency. In clinical practice, B6 is sometimes used in multivitamin formulations aimed at improving general energy levels or combating fatigue, particularly in populations at risk for deficiency (such as the elderly, pregnant individuals, or those with malabsorption syndromes).

However, scientific evidence directly supporting the use of vitamin B6 supplementation to treat fatigue in otherwise healthy, non-deficient individuals is limited and inconsistent. Most studies show that B6 supplementation does not reduce fatigue unless a deficiency is present. Some small studies and anecdotal reports suggest a possible benefit in conditions such as premenstrual syndrome (PMS)-related fatigue, but large, well-controlled clinical trials are lacking.

In summary, the use of vitamin B6 to treat or support fatigue is scientifically justified only in the context of deficiency, with strong evidence for correcting fatigue in that scenario (evidence rating: 4-5). For general fatigue in the absence of deficiency, the evidence is weak (rating: 0-2), and routine supplementation is not widely supported by rigorous scientific data.

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Other ingredients used for Fatigue

1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Acai berry
Acetyl L-carnitine
Acetyl-L-Tyrosine
Achyranthes
Adenophora
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
adrenal cortex
Adzuki bean
Agarwood
Agrimonia pilosa
AHCC
Akebia
Albizia
Aletris
Alfalfa
Algae
Algal protein
Allium tuberosum
Almond fruit
Alpha D-ribofuranose
Alpha lactalbumin
Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amaranth
amber
American Liverleaf
amino acids
Amor seco
anamu
anemarrhena asphodeloides
Angelica
animal protein
anthocyanins
antler
Antrodia camphorata
apple
apple cider vinegar
Aralia
Ardisia
Areca
Arginine aspartate
arginine creatine
Arginine malate
Arginine orotate
Arisaema
arjun tree
arjuna
arjunic acid
Armillaria mellea
ashitaba
ashwagandha
asparagus
aspartic acid
astaxanthin
aster root
astragaloside
astragalus
atractylodes
atractylone
Autumn Olive
avens
ba ji tian
baccosides
bacoside
bacteria
baicalin
banana
baobab
barley
Basidiomycota
Bassia scoparia
Bauhinia
BCAA
bee pollen
beef
Beef liver
beet
bergamot
beta-alanine
beta-hydroxybutyrate
betel
betony
Bifidobacterium breve
big quaking grass
bignay
biota seed
bird\'s nest
black cumin
black garlic
black ginger
black gram
black salt
black seed
black tea
Blepharis
Blue-Green Alage
Boerhavia diffusa
bone marrow
bonito peptide
Borassus aethiopum
borassus palm
borneol
bottle gourd
bovine heart
bovine kidney
bovine liver
bovine spleen
brahmi
branched-chain amino acids
breadnut
Broussonetia
Bupleurum
bupleurum falcatum
burdock
C-phycocyanin
cactus
caffeine
California chia
Camellia sinensis
Canscora
cardamom
Carthamus
cat's claw
catalpol
caterpillar mushroom
catuaba
Centella asiatica
Centella triterpenes
cereal grass
Cereus
chaga mushroom
chanterelle
chard
chen pi
chestnut
chia seed
chia seed
Chinese fleeceflower
Chinese Ligustrum berry
Chinese mountain ant
Chinese pond turtle
Chinese salvia root
Chinese silkvine
chlorella
Chlorophytum
chocolate
chokeberry
Chondracanthus chamissoi
Chondrus
chuchuhuasi
Cinnamomum
cistanche
citrus sinensis (proprietary)
Clary sage
coca
cocarboxylase
cocoa
coconut
Coconut Water
Codonopsis
coenzyme Q10 (CoQ10)
coffee fruit
cola nut
cordyceps
coriolus mushroom
corktree
costus
cowpea
creatine
creatine monohydrate
cumin
curcumen
currant
curry leaf
cyanobacteria
Cyanotis vaga
Cyathula
Cyclanthera pedata
Cymbopogon martini
Cynomorium
D-Ribose
damiana
date
deer root
deer velvet
Dendrobium
devil\'s club
dextrose
DHEA
DHEA (dehydroepiandrosterone)
dibenzo-alpha pyrones
dioscorea
DMPX
dodder
dodeca-2E, 4E-dienoic acid isobutylamide
Dolichos
dong quai
dragon fruit
dragonhead
duckweed
dulse
dulse leaf
durian
ecdysteroids
Ecklonia
electrolytes blend (proprietary)
eleuthero
elk antler
Embelia
emblicanin
enokitake
Ephedra
ephedrine
ergothioneine
eriocitrin
Erodium cicutarium
Erythropalum scandens
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Euglena gracilis
Eupolyphaga sinensis
European five-finger grass
European hornbeam
Euryale seed
Eurycoma Longifolia
eurycomanone
fatty acids
fennel
fenugreek
fenuside
finger-leaf morning glory
fish
fish protein
Flammulina velutipes
flat-stem milk-vetch
flavin mononucleotide
Flemingia philippinensis
fo-ti
folate
folic acid
Foxtail millet
fruit and vegetable blend (proprietary)
fu ling
fulvic acid
fungus
furostanols
gamma-glutamylcysteine
ganoderma
garden cress
gastrodia
Gentianella alborosea
Gerovital H3
giant blazingstar
ginseng
Ginsenosides
Glechoma hederacea
glucose
Glutathione
Glycosaponin
GMS-ribose
goji berry
gooseberry
gotu kola
Greek mountain tea
green tea
guanidinoacetic acid
guarana
Guaranine
guayusa
Gypenoside
haliotis
Hemidesmus
Hempnettle
Herb Robert
hericium mushroom
hibiscus
hijiki
Himalaya berry
Himalayan salt
honeybush
horny goat weed
horse gram
Horsemint
hydroxymethylbutyrate
Hygrophila
hypsizygus marmoreus
icariin
Ilex
Indian fagonia
Indian frankincense
Indian sarsparilla
Indian tinospora
iridoid glycosides
iridoids
iron
isomaltulose
Jaboticaba
Japanese kadsura
Jatoba
jiaogulan
joe-pye
jujube
Kefir
ketone salts
ketosterones
kiwi
knotweed
Kokam
Kokilaksha
kola nut
Kombucha
kucha tea
kuding tea
kudzu
Kukicha
Kumquat
Kutkins
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
l-carnitine
L-cysteine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
lactiplantibacillus plantarum
Lactoferrin
Legume protein
lemon balm
Lentinula edodes mycelia
Leptadenia
ligustilides
Ligustrum
Lindera
lingzhi
lion's mane
liquid liver fractions
little ironweed
longan
Loranthus
lotus
lotus seed
lucuma
lychee
Lycium
Lycopodium
maca
macaenes
macamides
magnesium
maitake mushroom
Malay bush
malic acid
malt
mandarin
mangiferin
mango
mangosteen
maral root
Marine lipid
Marjoram
Massularia acuminata
Matcha
Mate
Melatonin
Methylcobalamin
Methylliberine
Methylxanthine
Milk
Milk Protein
millet seed
Mimosa
Ming Dang Shen
Mistletoe
Molasses
Momordica
Morinda
Moringa
Morus
Mountain pride
Muira puama
Mulberry
Mung bean
Mushroom
NADH
Nardostachys
Natsudaidai
Nettle
nicotinamide riboside
noni
nopal
nut grass
oat
okra
omega-3 fatty acids
Onosma bracteatum
oolong tea
Ophiopogon
ophiopogon root
orange
orchid
Orchis latifolia
Ornithine
ornithine alpha-ketoglutarate
ornithine L-aspartic acid
Oroxylum indicum
oryza
Osmanthus
oxaloacetic acid
Oxindole alkaloids
Oxypregnane glycoside
oyster mushroom
paeoniflorin
Palatinose
pantothenic acid (vitamin B5)
paraxanthine
parsley
Passionfruit
Pentacyclic triterpenoids
Pentatropis capensis
peony
Pepper
Peppermint
Peptides
Persimmon
Phaeophyceae
phellodendron amurense
Phosphocreatine
Phyllanthus
Physalis angulata
Phytoecdysteroid
Piper nigrum
Plankton
Pleurotus eryngii
plum fruit
pollen
polygala root
Polygonatum
Polygonum
polyporous mushroom
polysaccharides
pomegranate
Portulaca
potassium
prebiotic blend (proprietary)
Prickly Pear Cactus
Propionyl-L-Carnitine
protein
prune
Pseudostellaria
Puerain
punarnava
purslane
Pycnogenol
pyrroloquinoline disodium salt
pyrroloquinoline quinone
pyruvate
quail egg
quercetin
quinoa
Quinoa Protein
Rehmannia
rehmannia glutinosa
reishi mushroom
relora® (proprietary)
Rhaponticum
Rhodiola
Rhodymenia
riboflavin (vitamin B2)
ribose
rice
robusta coffee
rockweed
Rooibos
root tuber
Rosa roxburghii
Rosabin
rosavins
rosemary
royal jelly
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
Rubus
Safed musli
Salidroside
Salvia
saponins
Sarivan
sarsaparilla
Scabrous Gentian
Schisandrins
Schizandrol A
scrophularia root
sea salt
seaweed
Selaginella
Semecarpus anacardium
sesame
Sete sangrias
Shark Liver Oil
Shataverins
shiitake mushroom
Shilajit
Sichuan Lovage
Sida cordifolia
silk tree
Silkmoth
smilax
Sophora
soursop
Spanish Needle
Spantholobus
Spelt
Spikenard
spinach
spirulina
spruce
Sulbutiamine
suma
Sumac
Sweet Bay
Sweet Orange alcohol
Sword Bean
Tamarind
Tea
Teacrine
Tejocote
Terminalia
Theacrine
Thiamin (vitamin B1)
thyroid substance
Tiger Nut
Tinospora cordifolia
Tongkat ali
trace minerals
Trametes
Tremella
Trichilia catigua
Trichopus zeylanicus
Trimethylglycine (TMG)
Triphala
Turkey tail mushroom
turmeric
Turtle Head
ubiquinol
Uncaria
Urolithin A
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
Vegetable Protein
velvet bean
Vetiver
Vine tea
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
Water Pepper
Watercress
Waterhyssop
Watermelon
Wax Gourd
Wheat
wheat germ
wheat grass
Whey protein
White Tea
whole adrenal glandular
Winter Begonia
Withanolides
Wood betony
Wulinshen
Xanthine
Xanthone
Xanthophyll
Xylaria nigripes
Yeast
Yerba buena
Yerba mate
Yohimbine
Yuzu
Zapilopatle Bean
Zedoary
Zucchini
β-nicotinamide mononucleotide (NMN)

Other health conditions supported by vitamin B6

Alcoholism
Amenorrhea
Anemia
Anxiety
Anxiety Disorders
Anger (excessive)
Arthritis
Attention Deficit Disorder
Autism
Bell's Palsy
Burning Feet or Hands
Carpal Tunnel Syndrome
Chemotherapy (reducing side effects)
Depression
Diabetes
Dysmenorrhea
Emotional Sensitivity
Energy (lack of)
Epilepsy
Fatigue
Hair (loss or thinning)
Hair Care (general)
Hangover
Hashimoto's Disease
Hiccups
Hot Flashes
Infertility
Inflammation
Insomnia
Irritability
Kidney Stones
Liver Detoxification
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Mood Swings
Morning Sickness
Nausea and Vomiting
Nerve Damage
Nervous Exhaustion
Nervousness
Neuralgia and Neuritis
Nightmares
Numbness
Obsessive Compulsive Disorder
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Rheumatoid Arthritis
Schizophrenia
Seborrhea
Seizures
Sleep (restless and disturbed)
Sore or Geographic Tongue
Stress
Thinking (cloudy)
Tics
TMJ
Tuberculosis
Twitching
Worry

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6
For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by vitamin B6

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6For the health condition: Fatigue

Table of Contents

Synopsis

Other ingredients used for Fatigue

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Fatigue