Evidence supporting the use of: Vitamin B12
For the body system: Gastrointestinal Tract

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B12 (cobalamin) has a scientifically validated role in supporting the gastrointestinal (GI) tract, primarily due to its necessity for proper cell division and maintenance of the mucosal lining of the GI system. Vitamin B12 is absorbed in the ileum, a section of the small intestine, with the help of intrinsic factor produced by the stomach. Deficiency in B12 can lead to a range of gastrointestinal symptoms, including glossitis, appetite loss, diarrhea, and malabsorption, as well as more severe structural changes such as atrophic gastritis and changes in the intestinal mucosa. Clinical studies indicate that B12 supplementation reverses these symptoms in deficient individuals.

Furthermore, certain gastrointestinal disorders, such as pernicious anemia, Crohn’s disease, celiac disease, and surgical removal of parts of the stomach or ileum, can impair B12 absorption, leading to secondary deficiencies. Supplementation in these populations is standard medical practice and supported by clinical guidelines. However, for the general population without B12 deficiency or GI pathology, evidence for B12 supporting GI tract health is limited. Overall, the scientific consensus is strong regarding the necessity of B12 for normal GI function in the context of deficiency, but supplementation beyond correcting deficiency does not appear to provide added GI benefits.

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