Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pantothenic acid (vitamin B5) is an essential vitamin involved in numerous physiological processes, particularly as a component of coenzyme A, which is critical for fatty acid metabolism and the synthesis of steroid hormones. The glandular system, which includes endocrine glands such as the adrenal glands, relies on pantothenic acid for hormone production. Several studies—primarily in animal models and limited human trials—have indicated that pantothenic acid deficiency can impair adrenal function, leading to reduced synthesis of adrenal hormones such as cortisol. Historical nutritional research (e.g., Fry et al., 1976) demonstrated that pantothenic acid is necessary for the maintenance of adrenal gland structure and function in animals.

In the context of dietary supplementation, pantothenic acid is sometimes marketed to support "adrenal health" or general glandular function, based on its biochemical role in steroidogenesis. However, while its necessity for normal adrenal function is established, robust clinical trials demonstrating that supplementation offers additional benefit to glandular health in individuals without deficiency are lacking. Thus, the scientific evidence supports pantothenic acid’s essential role in glandular (especially adrenal) function, but evidence for benefits from supplementation beyond preventing deficiency is limited. The evidence rating of 3 reflects a moderate level of support for its physiological necessity, but not for additional therapeutic use in healthy individuals.

More about pantothenic acid (vitamin B5)
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