Relationship: Heart and folate

Evidence supporting the use of: Folate
For the body system: Heart

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) is scientifically validated as important for heart health, primarily due to its role in regulating homocysteine levels in the blood. Elevated homocysteine is a known risk factor for cardiovascular disease, and folate, along with vitamins B6 and B12, is involved in its metabolism. Multiple observational studies and meta-analyses have demonstrated that low levels of folate are associated with higher homocysteine and increased cardiovascular risk. Supplementation with folic acid reliably lowers homocysteine concentrations, as confirmed by randomized controlled trials (RCTs).

However, the translation of reduced homocysteine to reduced cardiovascular events (such as heart attack and stroke) is less clear. Large RCTs, including the HOPE-2 and NORVIT trials, have generally shown that while folic acid supplementation lowers homocysteine, it does not significantly reduce the incidence of heart attacks or overall cardiovascular mortality in populations with adequate folate intake. There is, however, some evidence that folic acid supplementation may reduce the risk of stroke, particularly in populations where folate deficiency is common and foods are not fortified.

In summary, while folate is essential for cardiovascular health and reliably lowers a known risk marker (homocysteine), the evidence that supplementation reduces cardiovascular events is mixed. The scientific rationale for folate supporting the heart system is therefore moderate (3/5), with the strongest support being in homocysteine management rather than direct prevention of heart disease or heart attacks.

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Other body systems supported by folate

Blood
Brain
Digestive System
Female Reproductive System
Gastrointestinal Tract
Heart
Immune System
Intestinal System
Liver
Male Reproductive System
Nails
Nerves
Ovaries
Reproductive System
Small Intestines
Uterus

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: Folate
For the body system: Heart

Table of Contents

Synopsis

Other ingredients that support Heart

Other body systems supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the body system: Heart

Table of Contents

Synopsis

Other ingredients that support Heart

Other body systems supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the body system: Heart