Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is scientifically recognized as an essential nutrient involved in various physiological processes, including those related to cardiovascular health. Its primary cardiovascular importance stems from its role in homocysteine metabolism. Elevated homocysteine levels in the blood are considered a risk factor for cardiovascular diseases such as coronary artery disease and stroke. Vitamin B12, along with folate and vitamin B6, helps to convert homocysteine to methionine, thus reducing homocysteine concentrations. Several observational studies have shown associations between low B12 status, elevated homocysteine, and increased cardiovascular risk. However, interventional trials supplementing vitamin B12 (often in combination with folic acid and B6) have not consistently demonstrated a reduction in cardiovascular events, despite reductions in homocysteine levels. As a result, major clinical guidelines do not currently recommend vitamin B12 supplementation specifically for heart disease prevention in the general population, except in cases of deficiency. In summary, while there is a mechanistic and epidemiological link between B12 status, homocysteine, and cardiovascular health, direct clinical evidence supporting B12 supplementation for heart disease prevention or treatment is limited. Therefore, the overall evidence for vitamin B12 in supporting the heart system is rated as modest (2/5).

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Other body systems supported by vitamin B12

Products containing vitamin B12

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