Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been studied for its role in supporting cardiovascular health, though the evidence is modest and not definitive. Scientifically, vitamin B6 is involved in the metabolism of homocysteine, an amino acid in the blood. Elevated homocysteine levels are considered a risk factor for cardiovascular disease, and vitamin B6, along with folic acid and vitamin B12, helps to lower homocysteine concentrations. Some observational studies have associated higher vitamin B6 intake or blood levels with reduced risk of heart disease. However, large randomized controlled trials have not consistently shown that B6 supplementation alone reduces cardiovascular events or mortality. The US National Institutes of Health (NIH) notes that while B6 is essential for general health and homocysteine metabolism, its direct benefit in preventing or treating heart disease remains unproven. Therefore, while there is a plausible biochemical rationale and some supportive epidemiological data, the overall scientific evidence is moderate and not strong enough to recommend B6 supplementation specifically for cardiovascular protection unless there is a deficiency.

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