Relationship: Liver and folate

Evidence supporting the use of: Folate
For the body system: Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) is a water-soluble B-vitamin that plays a crucial role in DNA synthesis, repair, and methylation, as well as amino acid metabolism. Its use in supporting liver health is primarily justified by scientific evidence, though the evidence is moderate rather than overwhelming. The liver is a key organ in folate metabolism; it stores a significant portion of the body's folate and is involved in converting folate to its biologically active forms. Folate deficiency can lead to elevated homocysteine levels, which are associated with liver disease progression, particularly in conditions such as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease. Some studies indicate that adequate folate status may help reduce the risk of hepatic steatosis and fibrosis by supporting methylation reactions and reducing oxidative stress. Additionally, folate supplementation has been evaluated as part of strategies to lower homocysteine and potentially slow liver disease progression. However, while animal and human observational studies support these mechanisms, direct clinical trial evidence for folate supplementation as a treatment for liver disease remains limited. As such, folate is recognized as important for overall liver function and health, especially in the context of deficiency, but it is not considered a primary therapeutic agent for liver disorders.

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Other body systems supported by folate

Blood
Brain
Digestive System
Female Reproductive System
Gastrointestinal Tract
Heart
Immune System
Intestinal System
Liver
Male Reproductive System
Nails
Nerves
Ovaries
Reproductive System
Small Intestines
Uterus

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: Folate
For the body system: Liver

Table of Contents

Synopsis

Other ingredients that support Liver

Other body systems supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the body system: Liver

Table of Contents

Synopsis

Other ingredients that support Liver

Other body systems supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the body system: Liver