Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacinamide (vitamin B3) does have some scientific basis for supporting liver health, though the evidence is limited and not robust. Niacinamide is a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme involved in numerous metabolic processes, including those in the liver. NAD+ is crucial for cellular energy production, oxidative stress management, and DNA repair. In animal studies and some human clinical observations, deficiencies in niacin (and its derivatives) have been associated with hepatic dysfunction and an increased risk of fatty liver disease. Furthermore, niacinamide and related compounds have been studied for their potential to protect against certain types of chemical-induced liver injury, primarily due to their antioxidant and anti-inflammatory actions. However, the majority of clinical research on niacin (another form of vitamin B3) and liver health pertains to its use in treating hyperlipidemia, which may secondarily benefit liver fat metabolism. High doses of niacin have been associated with hepatotoxicity, but niacinamide is generally considered less hepatotoxic. There are no major clinical trials supporting routine use of niacinamide specifically for "liver detoxification" in the context of dietary supplements or alternative medicine, and its benefits for this purpose are largely extrapolated from basic biochemical roles rather than direct clinical outcomes. In summary, while there is a scientific rationale for niacinamide’s involvement in liver function, strong evidence for its use in liver detoxification or treatment of liver disease in humans is lacking, meriting a low-moderate evidence score.

More about niacinamide (vitamin B3)
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