Relationship: Male Reproductive System and folate

Evidence supporting the use of: Folate
For the body system: Male Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) has scientific evidence supporting its role in male reproductive health, though the strength of evidence is moderate. Folate is essential for DNA synthesis, repair, and methylation—processes vital for spermatogenesis. Multiple observational studies have found associations between higher folate intake or blood levels and improved sperm count, motility, and decreased DNA fragmentation in sperm. Some randomized controlled trials (RCTs) have also shown that folic acid supplementation, alone or in combination with zinc, can improve certain sperm parameters in subfertile men. However, results across studies remain somewhat inconsistent, and not all trials report significant benefits.

Mechanistically, folate deficiency in men has been linked to increased homocysteine levels, which may negatively affect sperm quality and function. Animal studies further support the importance of folate in testicular function and fertility. Major health organizations and reproductive medicine societies recognize folate as an important nutrient for men attempting conception, but it is not universally recommended as a stand-alone intervention for male infertility due to variability in clinical outcomes. In summary, while there is a scientific basis for using folate to support the male reproductive system, especially concerning sperm health, more large-scale, high-quality trials are needed to clarify its efficacy and optimal usage.

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Other ingredients that support Male Reproductive System

amino acids
ashwagandha
aspartic acid
beta-sitosterol
sesame
boron
broccoli
caterpillar mushroom
cordyceps
cowage seed
d-alpha tocopherol
damiana
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
fenugreek
folate
ginseng
gokhru
l-arginine
l-citrulline
lycopene
maca
magnesium
melatonin
muira puama
nettle
parsley
pomegranate
protein
pumpkin
pygeum
rehmannia glutinosa
saffron
saw palmetto
selenium
black ginger
tongkat ali
tribulus
velvet bean
vitamin B
vitamin D
vitamin E
zinc
suma
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Black Seed
Butea monosperma
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Beef liver
Bulbine natalensis
Brazil nut
Ba Ji Tian
Butea superba
Bee products
Borassus aethiopum
Curculigo orchicides
Chinese Mountain Ant
Cucurbita
Cnidium
Clerodendrum phlomidis
Cynomorium
Chinese Fleeceflower
Chinese Pond Turtle
Chlorophytum
Cruciferous
Cyanotis Vaga
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D-Aspartic Acid
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walnut
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Other body systems supported by folate

Blood
Brain
Digestive System
Female Reproductive System
Gastrointestinal Tract
Heart
Immune System
Intestinal System
Liver
Male Reproductive System
Nails
Nerves
Ovaries
Reproductive System
Small Intestines
Uterus

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Evidence supporting the use of: Folate
For the body system: Male Reproductive System

Table of Contents

Synopsis

Other ingredients that support Male Reproductive System

Health Concerns

Brands

Evidence supporting the use of: FolateFor the body system: Male Reproductive System

Table of Contents

Synopsis

Other ingredients that support Male Reproductive System

Other body systems supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the body system: Male Reproductive System