Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Choline is an essential nutrient that plays a critical role in brain function, particularly in the synthesis of the neurotransmitter acetylcholine, which is involved in memory, mood, and other cognitive processes. Scientific interest in choline for memory and brain health is based on its biological importance and evidence from both animal and human studies. Several randomized controlled trials have investigated the effects of choline supplementation (or its derivatives, such as citicoline and alpha-GPC) on cognitive performance. Some studies suggest that choline supplementation may improve memory and attention in older adults with mild cognitive impairment and in stroke patients. A 2015 meta-analysis found modest benefits for cognitive function in aging adults, especially when using choline precursors like citicoline and alpha-GPC.

However, evidence for choline’s effectiveness in healthy adults or in preventing cognitive decline in the general population is limited and somewhat inconsistent. The most robust benefits appear in populations with existing choline deficiencies or certain neurological conditions. Overall, choline is widely accepted as essential for normal brain function, and deficiency can impair memory, but supplementation beyond the recommended dietary intake has only modest and specific effects. Thus, while scientific evidence exists, it does not unanimously support routine supplementation for memory enhancement in healthy individuals.

More about choline
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Other ingredients used for Memory and Brain Function

Other health conditions supported by choline

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