Relationship: Memory and Brain Function and folate

Evidence supporting the use of: Folate
For the health condition: Memory and Brain Function

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Source of validity: Scientific
Rating (out of 5): 2

Folate (vitamin B9) is an essential nutrient involved in numerous physiological processes, including DNA synthesis, repair, and methylation, as well as the metabolism of homocysteine. There is some scientific rationale for the use of folate in supporting memory and brain function, particularly because folate deficiency is associated with cognitive impairment and neuropsychiatric disorders. Several observational studies have found correlations between low folate levels and increased risk of cognitive decline, dementia, and Alzheimer's disease, especially in older adults. Additionally, elevated homocysteine levels—often resulting from inadequate folate—have been linked to poorer cognitive outcomes and greater risk of neurodegenerative diseases.

However, while supplementation with folate can correct a deficiency and may help prevent cognitive decline in individuals with low folate status, large randomized controlled trials in generally healthy populations have provided mixed results. Most studies have not demonstrated significant cognitive benefits from folate supplementation in people with normal folate levels. Therefore, current scientific evidence supports the use of folate for memory and brain function primarily in those who are deficient, but not as a general cognitive enhancer. Professional guidelines recommend maintaining adequate folate intake for overall health, but do not specifically endorse high-dose supplementation for cognitive improvement in the absence of deficiency.

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2'-Fucosyllactose
acai berry
acetyl l-carnitine
algal oil
alpha-pinene
amino acids
anchovies
anthocyanins
ashwagandha
asparagus
astaxanthin
waterhyssop
beet
berry flavor
beta caryophyllene
bifidobacterium longum
bilberry
black currant
black garlic
sesame
black tea
blackberry
blueberry
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broccoli
caprylic acid
catechins
caterpillar mushroom
chaga mushroom
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choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish protein
folate
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginkgo biloba
glycerophosphocholine (GPC)
gooseberry
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grape
green tea
guarana
guayusa
hesperetin
huperzine A
inositol
jujube
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krill oil
kudzu
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l-carnitine
l-carnosine
l-serine
l-taurine
l-theanine
l-tyrosine
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lecithin
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lutein
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maca
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medium chain triglycerides (MCT)
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Evidence supporting the use of: Folate
For the health condition: Memory and Brain Function

Table of Contents

Synopsis

Other ingredients used for Memory and Brain Function

Other health conditions supported by folate

Products containing folate

Health Concerns

Brands

Evidence supporting the use of: FolateFor the health condition: Memory and Brain Function

Table of Contents

Synopsis

Other ingredients used for Memory and Brain Function

Other health conditions supported by folate

Products containing folate

Evidence supporting the use of: Folate
For the health condition: Memory and Brain Function