Evidence supporting the use of: Vitamin B6
For the health condition: Memory and Brain Function
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitamin B6 (pyridoxine) is involved in several biochemical processes essential for brain function, including neurotransmitter synthesis (such as serotonin, dopamine, and GABA), homocysteine metabolism, and overall neuronal health. There is scientific interest in the role of vitamin B6 in cognitive function, particularly in older adults and in the context of mild cognitive impairment (MCI). Some observational studies have associated low vitamin B6 levels with poorer cognitive performance and higher risk of cognitive decline. Additionally, vitamin B6, often in combination with other B vitamins (B12 and folic acid), has been investigated in randomized controlled trials to assess its effect on memory and cognitive function, largely due to its effect on lowering homocysteine—a risk factor for cognitive decline.
However, the overall evidence remains limited and mixed. While supplementation corrects deficiencies and may benefit cognition in people who are deficient, high-quality trials in healthy older adults or those with mild cognitive impairment have generally not shown significant improvements in memory or broader cognitive function from vitamin B6 supplementation alone. Most benefits are seen in correcting deficiencies rather than enhancing brain function in the general population. Thus, while there is a scientific rationale and some supporting evidence, it is not robust, and the effect size in non-deficient individuals is likely small.
Other ingredients used for Memory and Brain Function
1,3,7-Trimethylpurine-2,6-dione2'-Fucosyllactose
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Acetyl-L-Tyrosine
Acetylcholine
Agarwood
Agmatine
Algae
algal oil
Almond fruit
Alpha glyceryl
alpha-lipoic acid
alpha-pinene
amentoflavone
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
andrographolide
aniracetam
anserine
anthocyanidins
anthocyanins
anthocyanosides
apigenin
arachidonic acid
Aronia melanocarpa
ashitaba
ashwagandha
asparagus
astaxanthin
avocado
baccosides
Bacopa
Bacopin
bacoside
baicalein
baicalin
Basidiomycota
Beef liver
beet
beta caryophyllene
beta-hydroxybutyrate
Bifidobacteria
Bifidobacterium longum
bilberry
bilobalide
biota seed
bird\'s nest
black currant
black garlic
black ginger
black seed
black tea
blackberry
Blepharis
Blue-Green Alage
blueberry
Boswellia
brahmi
breadnut
broccoli
butylphthalide
Camellia sinensis
Canscora
caprylic acid
carnosic acid
Carnosine
catalpol
catechins
caterpillar mushroom
catuaba
Celastrus
Centella asiatica
Centella triterpenes
centrophenoxine
chaga mushroom
chebulic acid
Chinese Ligustrum berry
Chinese mountain ant
Chinese salvia root
chocolate
choline
chrysanthemum
cinnamic acid
cinnamon
cistanche
citicoline
cocoa
cod liver oil
Codonopsis
coenzyme Q10 (CoQ10)
coffee fruit
cola nut
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
creatine
creatine monohydrate
crocetin
cruciferous
curcumin
currant
cyanidin
cyanobacteria
cytidine
d-alpha tocopherol
danshen
date
decursin
decursinol
Dendrobium
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
dibenzo-alpha pyrones
docosahexaenoic Acid
DPA (docosapentaenoic acid)
egg
eicosapentaenoic acid
eleuthero
elk antler
emblicanin
enokitake
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
Eucommia ulmoides
ferulic acid
fisetin
fish
fish protein
Flammulina velutipes
flavanols
flavanones
flavans
flavoglycosides
flavones
fo-ti
folate
folic acid
frankincense
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
fucosterol
galangin
galantamine
gallic acid
garcinol
gastrodin
ginkgetin
ginkgo biloba
ginkgo flavone glycoside
ginkgoheteroside
ginkgolides
Ginkgoside
Ginsenosides
Glucoraphanin
glucose
Glutamate
glycerophosphocholine (GPC)
Glycine
Glycosphingolipids
goji berry
gooseberry
gotu kola
grape
green tea
guarana
Guaranine
guayusa
Gypenoside
hazelnut
Hericenones
hericium mushroom
hesperetin
Homotaurine
Honokiol
huperzine A
hydroxytyrosol
icariin
Idebenone
Indian frankincense
inositol
isoliquiritigenin
isovitexin
Jatamansi
jiaogulan
jujube
Kaempferol
kale
krill oil
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
L-carnosine
L-serine
L-taurine
L-theanine
l-tyrosine
Lactobacillus reuteri
lecithin
lemon balm
linalool
lingzhi
lion's mane
longan
lotus seed
lutein
luteolin
Lycium
lysophosphatidylcholine
maca
magnolol
mangiferin
Marine fat
Marine lipid
Matcha
Mate
medium chain triglycerides (MCT)
Methoxylated flavones
Methylcobalamin
Methylxanthine
Monounsaturated fat
Moringa
Morus
Muira puama
Mulberry
Myricetin
NADH
Nardostachys
Naringenin
Naringin
Nervonic acid
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nobiletin
oat
oleic acid
olive
omega-3 fatty acids
oolong tea
ophiopogon root
Osthole
paeoniflorin
paraxanthine
perilla
Periwinkle
phosphatidylcholine
phosphatidylserine
Phosphocreatine
phospholipids
Phthalides
phytocannabinoids
pine bark
Piperine
Plankton
Pleurotus eryngii
pollen
Polydatin
Polygala
polygala root
Polygonum
polysaccharides
polyunsaturated fat
pomegranate
pregnenolone
prolyl endopeptidase (PEP)
Puerain
Puerarin
pumpkin
punicalagins
purslane
Pycnogenol
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quail egg
quercetin
Rehmannia
reishi mushroom
resveratrol
Rhodiola
robusta coffee
root tuber
rosmarinic acid
royal jelly
Rubiaceae
rutin
saffron
Safranal
Salidroside
Salmon Oil
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sarcosine
Schisandrins
Schizandrol A
Schizochytrium
Schizochytrium Oil
seaweed
selenium
sesame
Shankhpushpi
Shilajit
Sialic acid
Soy
specialized pro-resolving mediators (SPMs)
spinach
spirulina
Stilbenoid
strawberry
Sulbutiamine
Sulforaphane
sulforaphane glucosinolate
suma
Tanshinone
Taurine
Taxillus chinensis
Terminalia
terpene lactones
Threonic acid
Tiger Nut
Tinospora cordifolia
tocotrienols
Trans-pterostilbene
Tremella
Triacetyluridine
Trichilia catigua
Trichopus zeylanicus
Tumerone
turmeric
Turmerones
ubiquinol
Uncaria
Uridine
Urolithin A
vegetable and fruit blend (proprietary)
velvet bean
Vincamine
Vinpocetine
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
Vitexin
Walnut
Waterhyssop
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
Xanthophyll
Xylaria nigripes
Yerba mate
Yohimbine
Yumberry
Yuzu
Zinc
β-nicotinamide mononucleotide (NMN)
Other health conditions supported by vitamin B6
AlcoholismAmenorrhea
Anemia
Anxiety
Anxiety Disorders
Anger (excessive)
Arthritis
Attention Deficit Disorder
Autism
Bell's Palsy
Burning Feet or Hands
Carpal Tunnel Syndrome
Chemotherapy (reducing side effects)
Depression
Diabetes
Dysmenorrhea
Emotional Sensitivity
Energy (lack of)
Epilepsy
Fatigue
Hair (loss or thinning)
Hair Care (general)
Hangover
Hashimoto's Disease
Hiccups
Hot Flashes
Infertility
Inflammation
Insomnia
Irritability
Kidney Stones
Liver Detoxification
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Mood Swings
Morning Sickness
Nausea and Vomiting
Nerve Damage
Nervous Exhaustion
Nervousness
Neuralgia and Neuritis
Nightmares
Numbness
Obsessive Compulsive Disorder
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Rheumatoid Arthritis
Schizophrenia
Seborrhea
Seizures
Sleep (restless and disturbed)
Sore or Geographic Tongue
Stress
Thinking (cloudy)
Tics
TMJ
Tuberculosis
Twitching
Worry
Products containing vitamin B6
Thorne
5-Hydroxytryptophan
Designs For Health
5-HTP Supreme™
Designs For Health
5-HTP Synergy™
Designs For Health
Acnutrol™
Integrative Therapeutics
Active B-Complex
Vitabase
Active Man's Formula
Vitabase
Active Woman's Multi
Designs For Health
Adrenal Complex
Designs For Health
Adrenal Complex
Metagenics
Adrenogen
Designs For Health
Adrenotone™
Designs For Health
Adrenotone™
Metagenics
AdvaClear
Metagenics
AdvaClear
Thorne
Advanced Bone Support Oscap
Thorne
Advanced Nutrients Multivitamin
Designs For Health
Amino Acid Supreme™
Designs For Health
Amino Acid Synergy
Pure Encapsulations
Amino-NR
Pure Encapsulations
Amino Replete
Metagenics
Axis Endo™ Mango
Douglas Laboratories
B-Complex
Vitabase
B-Complex 100 mg Sustained Release
Thorne
B-Complex #12
Thorne
B-Complex #6
Pure Encapsulations
B-Complex Plus
Pure Encapsulations
B-Complex Plus
Designs For Health
B-Supreme
Designs For Health
B-Supreme
Pure Encapsulations
B6 Complex
Pure Encapsulations
B6 Complex
Thorne
Basic B Complex
Thorne
Basic Nutrients 2/Day Multivitamin
Thorne
Basic Prenatal Multivitamin
Pure Encapsulations
CarbCrave Complex
Thorne
Catalyte
Designs For Health
CatecholaCalm™
Metagenics
Ceralin® Forte
Vitabase
Cholesterol Support
Metagenics
Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics
Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics
Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics
Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics
Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics
Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics
Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics
Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics
Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics
Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics
Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics
Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics
Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics
Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics
Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics
Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics
Clear Change Daily Essentials
Integrative Therapeutics
Clinical Nutrients HP
Metagenics
Collagenics®
Metagenics
Cortico-B5B6®
Designs For Health
CraveArrest™
Thorne
Craving and Stress Support Relora Plus
Integrative Therapeutics
Detoxication Factors
Designs For Health
DFH Complete Multi™
Designs For Health
DFH Complete Multi™ with Copper
Designs For Health
DFH Complete Multi™ with Copper & Iron
Designs For Health
DopaBoost™
Pure Encapsulations
DopaPlus
Integrative Therapeutics
EHB
Pure Encapsulations
Emotional Wellness
Pure Encapsulations
Emotional Wellness
Designs For Health
EndoTrim™
Metagenics
Endura® Lemonade
Pure Encapsulations
Energize Plus™ Pure Pack
Metagenics
EstroFactors®
Metagenics
Fem EstroPlex®
Metagenics
Fem Prenatal®
Designs For Health
FemGuard+Balance™
Thorne
Ferrasorb
Metagenics
Fibroplex®
Pure Encapsulations
Folate 5,000 Plus
Metagenics
GI Sustain™ Powder
Metagenics
Glutagenics
Integrative Therapeutics
Glycemic Manager
Metagenics
Glycogenics
Vitabase
Hair, Skin & Nails Formula
Vitabase
Healthy Sleep Support
Metagenics
Hemagenics
Metagenics
Hemagenics
Metagenics
HerSynergy®
Pure Encapsulations
Homocysteine Factors
Pure Encapsulations
Homocysteine Factors
Designs For Health
Homocysteine Supreme™
Designs For Health
Homocysteine Supreme™
Designs For Health
Insomnitol™
Designs For Health
Insomnitol™ Chewables
Integrative Therapeutics
K-PAX MitoNutrients
Metagenics
Ketogenic Shake Chocolate
Metagenics
Ketogenic Shake Vanilla
Klean Athlete
Klean B-Complex
Klean Athlete
Klean Electrolytes ™
Klean Athlete
Klean Multivitamin ™
Pure Encapsulations
L-Tryptophan
Pure Encapsulations
L-Tryptophan
Douglas Laboratories
L-Tryptophan
Vitabase
Life's Essentials Plus
Metagenics
Lipo-Gen™
Metagenics
Lipo-Gen
Designs For Health
Liposomal B Supreme
Integrative Therapeutics
Lipotropic Complex
Pure Encapsulations
Lipotropic Detox
Pure Encapsulations
Liquid B-Complex
Pure Encapsulations
Liquid Magnesium
Douglas Laboratories
Liquid Multivitamin
Pure Encapsulations
LiquiNutrients
Designs For Health
LV-GB Complex™
Thorne
MediClear Plus
Thorne
Men's Multi 50+
Designs For Health
Metabolic Synergy™
Designs For Health
Metabolic Synergy™
Metagenics
MetaGlycemX™
Metagenics
MetaGlycemX
Metagenics
MetaKids Multi Soft Chew Grape
Metagenics
MetaKids Nutrition Powder Chocolate
Metagenics
MetaKids Nutrition Powder Vanilla
Metagenics
MetaRelax®
Thorne
Methyl-Guard
Thorne
Methyl-Guard Plus
Pure Encapsulations
MethylAssist
Metagenics
MethylCare
Designs For Health
Mitochondrial NRG™
Metagenics
MitoVive
Pure Encapsulations
MotilPro
Pure Encapsulations
Multi t/d
Pure Encapsulations
Multi t/d
Thorne
Multi-Vitamin Elite NSF
Thorne
Multi-Vitamin Elite NSF
Metagenics
Multigenics®
Metagenics
Multigenics Chewable Orange
Metagenics
Multigenics Intensive Care
Metagenics
Multigenics Intensive Care without Iron
Metagenics
Multigenics without Iron
Integrative Therapeutics
Multiplex-1 No-Iron
Designs For Health
NeuroCalm™
Designs For Health
Neurolink™
Pure Encapsulations
NeuroMood Pure Pack
Pure Encapsulations
NeuroPure
Designs For Health
NeuroRenew™
Pure Encapsulations
NR Longevity
Pure Encapsulations
Nutrient 950®
Pure Encapsulations
Nutrient 950®
Pure Encapsulations
Nutrient 950®
Pure Encapsulations
Nutrient 950® A without Copper & Iron
Pure Encapsulations
Nutrient 950® with NAC
Pure Encapsulations
Nutrient 950® with Vitamin K
Pure Encapsulations
Nutrient 950® without Copper, Iron & Iodine
Pure Encapsulations
Nutrient 950® without Iron
Pure Encapsulations
Nutrient 950® without Iron
Integrative Therapeutics
Nutrivitamin No-Iron
Pure Encapsulations
O.N.E.™ Multivitamin
Pure Encapsulations
O.N.E.™ Multivitamin
Pure Encapsulations
O.N.E.™ Multivitamin
Designs For Health
OcuForce™
Integrative Therapeutics
Osteoprime Forte
Integrative Therapeutics
Osteoprime Ultra
Designs For Health
P-5-P
Pure Encapsulations
P-5-P 50
Pure Encapsulations
P-5-P 50
Designs For Health
PaleoCleanse Plus™
Designs For Health
PaleoCleanse Plus™
Designs For Health
PaleoCleanse Plus™ Detox Program
Designs For Health
PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health
PaleoMeal®
Designs For Health
PaleoMeal®
Integrative Therapeutics
Physicians Elemental Diet Dextrose Free
Integrative Therapeutics
Physician's Elemental Diet
Integrative Therapeutics
Physician's Elemental Diet
Integrative Therapeutics
Physicians Elemental Diet Kit
Metagenics
PhytoMulti™ Multivitamin
Metagenics
PhytoMulti With Iron
Metagenics
PhytoMulti Without Iron
Metagenics
PhytoMultivitamin
Designs For Health
Plant Protein Cleanse
Designs For Health
Plant Protein Cleanse Plus™ 570g
Designs For Health
Plant Protein Meal
Designs For Health
Plant Protein Meal Plus
Designs For Health
Plant Protein Meal
Metagenics
PlusOne® Daily Prenatal Packs
Pure Encapsulations
Polyphenol Nutrients
Pure Encapsulations
Polyphenol Nutrients
Douglas Laboratories
Prenatal
Pure Encapsulations
PreNatal Nutrients
Pure Encapsulations
PreNatal Nutrients
Designs For Health
Prenatal Pro™
Designs For Health
Primal Multi™
Vitabase
Prostate Complex (Formerly Prostate Complete)
Designs For Health
Prostate Supreme™
Designs For Health
Prostate Supreme™
Integrative Therapeutics
ProThrivers Multivitamin
Pure Encapsulations
PureGenomics® B-Complex
Pure Encapsulations
PureGenomics® UltraMultivitamin
Pure Encapsulations
PureLean® Protein
Pure Encapsulations
PurePals
Pure Encapsulations
PurePals with Iron
Pure Encapsulations
PureResponse™ Multivitamin
Thorne
Pyridoxal 5 Phosphate B6
Pure Encapsulations
Rapid Calm
Vitabase
Relaxation Support
Douglas Laboratories
Relora ®-Plex
Metagenics
Renagen™ DTX
Pure Encapsulations
RevitalAge™ Nerve
Designs For Health
S-Acetyl Glutathione Synergy
Designs For Health
SAMe
Designs For Health
SAMe
Pure Encapsulations
SeroPlus
Metagenics
SeroSyn
Thorne
Stress B-Complex
Douglas Laboratories
Stress-B-Plus ™
Thorne
Stress Balance Phytisone
Designs For Health
StressArrest™
Vitabase
Super Antioxidant Formula
Vitabase
Super Fat Burner
Vitabase
Super Stress Formula
Metagenics
Testralin®
Metagenics
Trancor®
Designs For Health
Twice Daily Essential Packets
Designs For Health
Twice Daily Multi™
Designs For Health
Twice Daily Multi™
Designs For Health
Twice Daily Multi™
Douglas Laboratories
Ultra B-Complex
Pure Encapsulations
Ultra B-Complex with PQQ
Douglas Laboratories
Ultra Benfotiamine
Metagenics
Ultra Glucose Control® Chocolate
Metagenics
Ultra Glucose Control Chocolate
Metagenics
Ultra Glucose Control Vanilla
Metagenics
Ultra Glucose Control Vanilla
Douglas Laboratories
Ultra Preventive
Douglas Laboratories
Ultra Preventive
Douglas Laboratories
Ultra Preventive ® 2 Daily
Douglas Laboratories
Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories
Ultra Preventive ®-EZ Swallow
Douglas Laboratories
ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories
Ultra Preventive One Daily
Douglas Laboratories
Ultra Preventive® X
Metagenics
Ultra Prostagen Concentrated
Douglas Laboratories
Ultra Protein Green
Pure Encapsulations
Ultra Pure Pack
Metagenics
UltraClear Detox Powder
Metagenics
UltraClear Plus® Detox Powder
Metagenics
UltraClear Plus Detox Powder Berry
Metagenics
UltraClear Plus Detox Powder Pineapple/Banana
Metagenics
UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics
UltraClear Plus pH Detox Powder Vanilla
Metagenics
UltraClear RENEW Detox Powder Berry
Metagenics
UltraClear RENEW Detox Powder Chai
Metagenics
UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations
UltraDetox 10-Day Pure Pack
Metagenics
UltraGI Replenish® Chocolate
Metagenics
UltraGI Replenish Chocolate
Metagenics
UltraGI Replenish Vanilla
Metagenics
UltraGI Replenish Vanilla
Metagenics
UltraInflamX Plus 360°® Chocolate/Orange
Metagenics
UltraInflamX Plus 360° Mango
Metagenics
UltraInflamX Plus 360° Mango
Metagenics
UltraInflamX Plus 360° Orange
Metagenics
UltraInflamX Plus 360° Original Spice
Metagenics
UltraInflamX Plus 360° Pineapple/Banana
Metagenics
UltraInflamX Plus 360° Pineapple/Banana
Metagenics
UltraMeal Advanced Protein® Dutch Chocolate
Metagenics
UltraMeal Advanced Protein French Vanilla
Metagenics
UltraMeal Advanced Protein Plain
Metagenics
UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics
UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics
UltraMeal® Daily Support Dutch Chocolate
Metagenics
UltraMeal Daily Support Mixed Berry
Metagenics
UltraMeal Rice Vanilla
Pure Encapsulations
UltraNutrient®
Pure Encapsulations
UltraNutrient®
Pure Encapsulations
UltraNutrient®
Douglas Laboratories
Uro-Pro ®
Designs For Health
UT Synergy™
Pure Encapsulations
VisionPro Nutrients
Designs For Health
Vitamin B-6 Liquid
Designs For Health
Weight Loss Support Packets
Metagenics
Wellness Essentials Active Daily Packs
Metagenics
Wellness Essentials Brain Health Daily Packs
Metagenics
Wellness Essentials® Daily Packs
Metagenics
Wellness Essentials Healthy Balance Daily Packs
Metagenics
Wellness Essentials Men's Vitality Daily Packs
Metagenics
Wellness Essentials Women's Daily Packs
Metagenics
Wellness Essentials Women's Prime Daily Packs
Thorne
Women's Multi 50+
Pure Encapsulations
Women's Nutrients
Pure Encapsulations
Women's Nutrients
Designs For Health
Women's Twice Daily Essential Packets
Designs For Health
Zinc Supreme™
