Relationship: Memory and Brain Function and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Memory and Brain Function

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is involved in several biochemical processes essential for brain function, including neurotransmitter synthesis (such as serotonin, dopamine, and GABA), homocysteine metabolism, and overall neuronal health. There is scientific interest in the role of vitamin B6 in cognitive function, particularly in older adults and in the context of mild cognitive impairment (MCI). Some observational studies have associated low vitamin B6 levels with poorer cognitive performance and higher risk of cognitive decline. Additionally, vitamin B6, often in combination with other B vitamins (B12 and folic acid), has been investigated in randomized controlled trials to assess its effect on memory and cognitive function, largely due to its effect on lowering homocysteine—a risk factor for cognitive decline.

However, the overall evidence remains limited and mixed. While supplementation corrects deficiencies and may benefit cognition in people who are deficient, high-quality trials in healthy older adults or those with mild cognitive impairment have generally not shown significant improvements in memory or broader cognitive function from vitamin B6 supplementation alone. Most benefits are seen in correcting deficiencies rather than enhancing brain function in the general population. Thus, while there is a scientific rationale and some supporting evidence, it is not robust, and the effect size in non-deficient individuals is likely small.

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Other ingredients used for Memory and Brain Function

2'-Fucosyllactose
acai berry
acetyl l-carnitine
algal oil
alpha-pinene
amino acids
anchovies
anthocyanins
ashwagandha
asparagus
astaxanthin
waterhyssop
beet
berry flavor
beta caryophyllene
bifidobacterium longum
bilberry
black currant
black garlic
sesame
black tea
blackberry
blueberry
Indian frankincense
broccoli
caprylic acid
catechins
caterpillar mushroom
chaga mushroom
Chinese salvia root
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish protein
folate
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginkgo biloba
glycerophosphocholine (GPC)
gooseberry
gotu kola
grape
green tea
guarana
guayusa
hesperetin
huperzine A
inositol
jujube
kale
krill oil
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
l-carnosine
l-serine
l-taurine
l-theanine
l-tyrosine
lactobacillus reuteri
lecithin
lion's mane
lutein
luteolin
maca
mackerel
marine lipid
matcha
medium chain triglycerides (MCT)
moringa
muira puama
Acetyl-L-Tyrosine
naringin
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oat
oleic acid
olive
omega-3 fatty acids
ophiopogon root
perilla
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
pine bark
pollen
polygala root
pomegranate
pregnenolone
prolyl endopeptidase (PEP)
pumpkin
pyrroloquinoline disodium salt
quail egg
quercetin
reishi mushroom
resveratrol
rhodiola
rutin
saffron
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
black ginger
specialized pro-resolving mediators (SPMs)
spinach
spirulina
strawberry
sulforaphane glucosinolate
threonic acid
tocotrienols
tomato
trans-pterostilbene
almond fruit
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
velvet bean
vinpocetine
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
suma
jiaogulan
tinospora cordifolia
lingzhi
morus
root tuber
ferulic acid
chrysanthemum
cistanche
lotus seed
royal jelly
terpene lactones
purslane
yerba mate
biota seed
goji berry
algae
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
1,3,7-Trimethylpurine-2,6-dione
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
Arachidonic Acid
Apigenin
Aronia melanocarpa
Anserine
Alpha glyceryl
Andrographolide
Avocado
Agmatine
Adrafinil
Acetylcholine
Amentoflavone
Agarwood
Acacetin
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Acer Truncatum bunge
Aniracetam
anthocyanosides
Black Seed
Bilobalide
Butylphthalide
Beta-hydroxybutyrate
Breadnut
Blepharis
Beef liver
Baccosides
Bacopin
Baicalein
Basidiomycota
Boswellia
Brahmi
Bacopa
Blue-Green Alage
Bifidobacteria
bacoside
Baicalin
Bird's nest
Centrophenoxine
Camellia sinensis
Centella triterpenes
Chinese Mountain Ant
Cyanobacteria
Carnosine
Catalpol
Chebulic acid
Cod Liver Oil
Codonopsis
Cyanidin
Cruciferous
Centella asiatica
Cinnamic Acid
Chocolate
Chinese Ligustrum berry
Creatine
Catuaba
Convolvulus prostratus
Crocetin
Convolvulus Pluricaulis
Celastrus
Cytidine
cola nut
Canscora
Currant
Carnosic acid
Docosahexaenoic Acid
Danshen
Dendrobium
Decursin
Decursinol
Dibenzo-alpha pyrones
Date
epicatechin
Egg
Ergothioneine
Elk antler
Emblicanin
Eicosapentaenoic Acid
Eucommia ulmoides
Enokitake
Folic Acid
Flammulina velutipes
glucose
Glycine
Periwinkle
walnut
yohimbine

Other health conditions supported by vitamin B6

Alcoholism
Amenorrhea
Anemia
Anxiety
Anxiety Disorders
Anger (excessive)
Arthritis
Attention Deficit Disorder
Autism
Bell's Palsy
Burning Feet or Hands
Carpal Tunnel Syndrome
Chemotherapy (reducing side effects)
Depression
Diabetes
Dysmenorrhea
Emotional Sensitivity
Energy (lack of)
Epilepsy
Fatigue
Hair (loss or thinning)
Hair Care (general)
Hangover
Hashimoto's Disease
Hiccups
Hot Flashes
Infertility
Inflammation
Insomnia
Irritability
Kidney Stones
Liver Detoxification
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Mood Swings
Morning Sickness
Nausea and Vomiting
Nerve Damage
Nervous Exhaustion
Nervousness
Neuralgia and Neuritis
Nightmares
Numbness
Obsessive Compulsive Disorder
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Rheumatoid Arthritis
Schizophrenia
Seborrhea
Seizures
Sleep (restless and disturbed)
Sore or Geographic Tongue
Stress
Thinking (cloudy)
Tics
TMJ
Tuberculosis
Twitching
Worry

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6
For the health condition: Memory and Brain Function

Table of Contents

Synopsis

Other ingredients used for Memory and Brain Function

Other health conditions supported by vitamin B6

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6For the health condition: Memory and Brain Function

Table of Contents

Synopsis

Other ingredients used for Memory and Brain Function

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Memory and Brain Function