Relationship: Migraine and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated as a preventive and supportive treatment for migraine, particularly in the context of its role in homocysteine metabolism and neurotransmitter synthesis. Elevated homocysteine levels have been associated with an increased risk of migraine, especially migraine with aura. Vitamin B6, along with folate and vitamin B12, helps to lower homocysteine levels, which has led to research on its potential benefit in migraine management.

Several small clinical trials have examined vitamin B6 supplementation, sometimes in combination with other B vitamins, in people with migraine. A 2012 randomized controlled trial found that women with migraine with aura who received a combination of folic acid, vitamin B6, and vitamin B12 experienced a significant reduction in migraine frequency, severity, and disability compared to placebo. However, because these studies typically use B6 in combination with other B vitamins, it is difficult to isolate the specific effect of B6.

Laboratory studies suggest that vitamin B6 may also influence the synthesis of serotonin, a neurotransmitter involved in migraine pathophysiology. However, the clinical evidence for vitamin B6 alone is limited, and most guidelines do not recommend it as a first-line treatment. Overall, while there is some scientific rationale and preliminary evidence supporting its use, the quality and quantity of evidence are moderate at best.

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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Other health conditions supported by vitamin B6

Alcoholism
Amenorrhea
Anemia
Anxiety
Anxiety Disorders
Anger (excessive)
Arthritis
Attention Deficit Disorder
Autism
Bell's Palsy
Burning Feet or Hands
Carpal Tunnel Syndrome
Chemotherapy (reducing side effects)
Depression
Diabetes
Dysmenorrhea
Emotional Sensitivity
Energy (lack of)
Epilepsy
Fatigue
Hair (loss or thinning)
Hair Care (general)
Hangover
Hashimoto's Disease
Hiccups
Hot Flashes
Infertility
Inflammation
Insomnia
Irritability
Kidney Stones
Liver Detoxification
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Mood Swings
Morning Sickness
Nausea and Vomiting
Nerve Damage
Nervous Exhaustion
Nervousness
Neuralgia and Neuritis
Nightmares
Numbness
Obsessive Compulsive Disorder
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Rheumatoid Arthritis
Schizophrenia
Seborrhea
Seizures
Sleep (restless and disturbed)
Sore or Geographic Tongue
Stress
Thinking (cloudy)
Tics
TMJ
Tuberculosis
Twitching
Worry

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6
For the health condition: Migraine

Table of Contents

Synopsis

Other ingredients used for Migraine

Other health conditions supported by vitamin B6

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6For the health condition: Migraine

Table of Contents

Synopsis

Other ingredients used for Migraine

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Migraine