Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) is scientifically validated as an important nutrient in pregnancy, with a primary role in preventing neural tube defects in the developing fetus. Regarding miscarriage prevention, the evidence is more nuanced. Several observational studies indicate that women with adequate folate intake before and during early pregnancy have a lower risk of miscarriage compared to those with low folate levels. Folate is crucial for DNA synthesis, repair, and methylation—processes vital for proper embryonic development and placental function. Deficiencies in folate can lead to abnormal cell division and compromised placental health, both of which increase the risk of miscarriage.

However, most of the data supporting folate for miscarriage prevention are associative rather than causative. Randomized controlled trials specifically investigating the effect of folate supplementation on miscarriage rates are limited, and the results are mixed. Some studies suggest a protective effect, while others do not find a significant reduction in miscarriage risk solely due to folate supplementation. Despite these ambiguities, folate is recommended as standard prenatal care due to its well-established benefits for fetal development and safety profile. Thus, while folate is not a guaranteed preventive for miscarriage, there is moderate scientific rationale and indirect evidence supporting its role in reducing risk, meriting a rating of 3 out of 5.

More about folate
More about Miscarriage (prevention)

Other ingredients used for Miscarriage (prevention)

Other health conditions supported by folate

Products containing folate

Thorne 5-MTHF 1 mg Folate
Thorne 5-MTHF 5 mg Folate
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Vitabase Active Man's Formula
Vitabase Active Woman's Multi
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Thorne Advanced Nutrients Multivitamin
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Douglas Laboratories B-Complex
Vitabase B-Complex 100 mg Sustained Release
Thorne B-Complex #12
Thorne B-Complex #6
Pure Encapsulations B-Complex Plus
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Designs For Health B-Supreme
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Pure Encapsulations B12 Folate
Pure Encapsulations B6 Complex
Pure Encapsulations B6 Complex
Thorne Basic B Complex
Thorne Basic Nutrients 2/Day Multivitamin
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Metagenics Ceralin® Forte
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Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
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Pure Encapsulations Energize Plus™ Pure Pack
Metagenics EstroFactors®
Metagenics Fem Prenatal®
Designs For Health FemGuard+Balance™
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Pure Encapsulations Folate 1,000
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Pure Encapsulations Folate 5,000
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Designs For Health L-5-MTHF 1700MCG
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Metagenics MetaKids Nutrition Powder Chocolate
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Douglas Laboratories Methyl B12 Plus
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Thorne Multi-Vitamin Elite NSF
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Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
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Pure Encapsulations O.N.E.™ Multivitamin
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Designs For Health PaleoMeal®
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Designs For Health Twice Daily Multi™
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Douglas Laboratories Ultra Preventive ® 2 Daily
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Pure Encapsulations Ultra Pure Pack
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Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
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Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
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Metagenics UltraClear RENEW Detox Powder Vanilla
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Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
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Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
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Metagenics UltraInflamX Plus 360° Pineapple/Banana
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Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
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Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations VisionPro Nutrients
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets