Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacinamide (vitamin B3) has a scientifically validated role in supporting mitochondrial function. Niacinamide is a precursor for nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in cellular energy metabolism. NAD+ is essential for mitochondrial oxidative phosphorylation, where the majority of cellular ATP is produced. Numerous studies have shown that maintaining adequate NAD+ levels is critical for mitochondrial health, function, and biogenesis.

Preclinical research demonstrates that niacinamide supplementation can restore NAD+ pools in cells, particularly under conditions of metabolic stress or aging, where NAD+ levels often decline. Animal studies show that increased NAD+ availability through niacinamide or related compounds can improve mitochondrial function, energy production, and resilience to metabolic insults. In humans, although large-scale clinical trials are limited, smaller studies and mechanistic evidence support the role of niacinamide in boosting NAD+ and enhancing mitochondrial efficiency.

Overall, the use of niacinamide to support the mitochondrial body system is grounded in strong biochemical rationale and is increasingly supported by experimental and early clinical data. However, more large-scale human trials are needed to determine the full extent of its benefits in mitochondrial health and related diseases.

More about niacinamide (vitamin B3)
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Other ingredients that support Mitochondria

Other body systems supported by niacinamide (vitamin B3)

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