Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folate (vitamin B9) has strong scientific backing for its role in supporting the nervous system. Folate is essential for one-carbon metabolism, which is critical for the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. It is also required for the formation of S-adenosylmethionine (SAMe), a compound involved in methylation reactions vital for neural function and maintenance. Deficiency in folate can lead to neurological symptoms including cognitive impairment, depression, and neuropathy. Most notably, adequate folate is crucial during early pregnancy to prevent neural tube defects (NTDs) such as spina bifida and anencephaly in the developing fetus. Numerous randomized controlled trials and epidemiological studies have demonstrated that folic acid supplementation reduces the risk of NTDs, leading to widespread public health recommendations. In adults, low folate status has been associated with cognitive decline and increased risk of neurodegenerative diseases, although supplementation benefits in these contexts are less clear. Overall, the use of folate to support the nervous system is grounded in robust scientific evidence, particularly regarding its roles in neurodevelopment and neurotransmitter synthesis.

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Other ingredients that support Nerves

Other body systems supported by folate

Products containing folate

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