Relationship: PMS (general) and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: PMS (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is commonly used to support or treat symptoms of premenstrual syndrome (PMS). There is some scientific evidence supporting its use, though the quality and consistency of the data are moderate, not strong. Several randomized controlled trials and systematic reviews have investigated vitamin B6 supplementation (typically in doses of 50-100 mg/day) for PMS symptoms such as mood changes, irritability, and breast tenderness. A meta-analysis published in the British Journal of Obstetrics and Gynaecology (Wyatt et al., 1999) found that vitamin B6 was more effective than placebo in relieving overall PMS symptoms, particularly emotional symptoms, though the effect size was modest and some studies included in the review had methodological limitations.

The rationale for using vitamin B6 stems from its role in neurotransmitter synthesis, including serotonin and dopamine, which are implicated in mood regulation. Some women with PMS may have altered neurotransmitter metabolism, and B6 could potentially help correct this imbalance. However, more recent reviews (e.g., Cochrane Database, 2019) conclude that while there is some benefit, the evidence is not robust, and further high-quality trials are needed to confirm efficacy and safety. Vitamin B6 is generally safe at recommended doses, but chronic high intake can cause neuropathy.

In summary, the use of vitamin B6 for PMS is supported by moderate scientific evidence, particularly for mood-related symptoms, but it is not considered a definitive or first-line treatment.

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Other health conditions supported by vitamin B6

Alcoholism
Amenorrhea
Anemia
Anxiety
Anxiety Disorders
Anger (excessive)
Arthritis
Attention Deficit Disorder
Autism
Bell's Palsy
Burning Feet or Hands
Carpal Tunnel Syndrome
Chemotherapy (reducing side effects)
Depression
Diabetes
Dysmenorrhea
Emotional Sensitivity
Energy (lack of)
Epilepsy
Fatigue
Hair (loss or thinning)
Hair Care (general)
Hangover
Hashimoto's Disease
Hiccups
Hot Flashes
Infertility
Inflammation
Insomnia
Irritability
Kidney Stones
Liver Detoxification
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Mood Swings
Morning Sickness
Nausea and Vomiting
Nerve Damage
Nervous Exhaustion
Nervousness
Neuralgia and Neuritis
Nightmares
Numbness
Obsessive Compulsive Disorder
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Rheumatoid Arthritis
Schizophrenia
Seborrhea
Seizures
Sleep (restless and disturbed)
Sore or Geographic Tongue
Stress
Thinking (cloudy)
Tics
TMJ
Tuberculosis
Twitching
Worry

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Evidence supporting the use of: Vitamin B6
For the health condition: PMS (general)

Table of Contents

Synopsis

Other ingredients used for PMS (general)

Other health conditions supported by vitamin B6

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6For the health condition: PMS (general)

Table of Contents

Synopsis

Other ingredients used for PMS (general)

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: PMS (general)