Relationship: Stress and vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Stress

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is sometimes used to support or treat stress, largely based on its role in neurotransmitter synthesis and regulation of homocysteine metabolism. Scientifically, vitamin B6 is essential for the biosynthesis of neurotransmitters such as serotonin, dopamine, and GABA, all of which are implicated in mood regulation and stress response. Several observational studies have found associations between low levels of B6 and increased symptoms of depression and anxiety, both of which are closely linked to stress. However, evidence from randomized controlled trials specifically evaluating B6 supplementation for stress reduction in healthy individuals is limited and mixed.

Some studies suggest that supplementation with B6, often in combination with other B vitamins or magnesium, may help reduce perceived stress or improve mood in certain populations, such as those with pre-existing deficiencies or premenstrual syndrome (PMS). For instance, a few trials have reported mild improvements in mood and stress levels in women with PMS when supplemented with B6. Nevertheless, these benefits are generally modest, and it is unclear whether B6 alone provides significant stress-relieving effects in the general population.

Overall, while there is a plausible biological mechanism for B6’s involvement in stress and some supportive evidence, the scientific validation is not robust, and high-quality clinical trials are lacking. Thus, the evidence supporting the use of vitamin B6 specifically for stress management is weak to moderate (rated 2/5).

More about vitamin B6
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Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
7-Keto-DHEA
Acetyl L-carnitine
Acetyl-L-Tyrosine
Agarwood
Agastache
Agmatine
Agrimony
Akebia
Albizia
Algal protein
Alpha lactalbumin
alpha-pinene
AMP-activated protein kinase (AMPK)
anemarrhena asphodeloides
anise
Anserina
antler
Antrodia camphorata
apigenin
Aralia
Arginine aspartate
arjun tree
arjuna
ashitaba
ashwagandha
asparagus
astragalus
baccosides
Bacopa
Bacopin
bacoside
baicalein
baicalin
Baikal Skullcap
banana
banyan
Basidiomycota
bee pollen
benegut perilla (proprietary)
bergamot
betony
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum
biota seed
bird\'s nest
black ginger
Black spruce
black tea
bonito peptide
borage
brahmi
Buddha\'s hand
Bupleurum
bupleurum falcatum
C-phycocyanin
calamus
Calea zacatechichi
California poppy
Canscora
Capitate Valerian
cardamom
caterpillar mushroom
catnip
catuaba
Celastrus
Centella asiatica
Centella triterpenes
chaga mushroom
chamomile
cherimoya
Chinese fleeceflower
Chinese mountain ant
chocolate
chuchuhuasi
Clary sage
Clerodendrum phlomidis
coca
cocoa
Codonopsis
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
coriander
corktree
Corydalis
cowslip
curcumin
Cymbopogon martini
cypress
damiana
date
devil\'s club
DHA (docosahexaenoic acid)
dibenzo-alpha pyrones
dismutase
dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
dodeca-2E, 4E-dienoic acid isobutylamide
dong quai root
eleuthero
emblicanin
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
Eplotab
Erythrina
Eurycoma Longifolia
Ficus religiosa
fish
fish protein
flavones
fo-ti
fragrant rosewood
frankincense
Fumaria parviflora
GABA (gamma aminobutyric acid)
galactooligosaccharides
gardenia
gastrodin
Gelsemium
Ginsenosides
Glycine
goji berry
goldthread
gotu kola
green tea
Griffonia simplicifolia
guayusa
gum
heartwood
Hemidesmus
hericium mushroom
hibiscus
Homalomena
honeybush
Honokiol
hops
Hypericum
isoliquiritigenin
Japanese kadsura
jasmine
Jatamansi
jiaogulan
jujube
jujubosides
kanna
kava
kavalactones
kola nut
kuding tea
kudzu
Kukicha
L-ornithine
L-taurine
L-theanine
L-tryptophan
l-tyrosine
lactalbumin
lactiplantibacillus plantarum
lactium casein decapeptide
Lactobacillus brevis
Lactobacillus casei
Lactobacillus helveticus
Lactococcus rhamnosus
Lactucarium
Lactucopicrin
Large-leaved linden
Lavandin
lavender
lemon balm
Lentinula edodes mycelia
Leptadenia
limonene
linden
lingzhi
lion's mane
liquid liver fractions
longan
lotus
lupulinum
Lycium
maca
macaenes
macamides
magnesium
magnolia
magnolol
mandarin
mangiferin
maral root
Marjoram
Matcha
Mate
Meadow sage
Melatonin
Mentha haplocalyx
Mesembrine
Methylxanthine
Mimosa
Mimulus
Mint
Mistletoe
Monkey flower
Motherwort
Muira puama
Mulberry
Mulungu
Mung bean
Myrcene
Nardostachys
Night jessamine
noni
Nymphaea caerulea
oat
oolong tea
orchid
oriental arborvitae
Oxindole alkaloids
passionflower
Passionfruit
Patchouli oil
Pentatropis capensis
Pepper Bark Tree
Peppermint
perilla
phosphatidylserine
phospholipids
pine bark
Piper chaba
Pistachio
Polygala
polygala root
poppy
pregnenolone
Purple Monkeyflower
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quail egg
Rauvolfia
Rehmannia
relora® (proprietary)
Rhodiola
Rooibos
Rosabin
rosavins
rose
rose oil
Safed musli
saffron
Safranal
Salidroside
Sandy Everlasting
Sarivan
sarsaparilla
sceletium
Schisandrins
Schizandrol A
Scleranthus annus
Semecarpus anacardium
sesame
Shankhpushpi
Shataverins
Shilajit
Sida cordifolia
silk tree
skullcap
spearmint leaf
Speedwell
Spikenard
spinach
St. John's Wort
Stachytarpheta cayennensis
star of Bethlehem
suma
Sumbul
Sweet Woodruff
Tagara
Taurine
Taxillus chinensis
Tetracyclic oxindole alkaloids
Tetrahydropalmatine
Traveler's Joy
Trichilia catigua
Trichopus zeylanicus
Uncaria
Valerenic acid
Valerian root
Vanilla
velvet bean
Verbena
Vetiver
Viburnum
Vine tea
vitamin B12
vitamin B6
Vitexin
Waterhyssop
whole adrenal glandular
Withanolides
Wogonin
Wood betony
Xanthine
Xanthone
Xanthophyll
Xylaria nigripes
Yellow-Fruit Nightshade
Yerba mate
Ylang ylang
Yohimbine
Yumberry
Yuzu
Zinc

Other health conditions supported by vitamin B6

Alcoholism
Amenorrhea
Anemia
Anxiety
Anxiety Disorders
Anger (excessive)
Arthritis
Attention Deficit Disorder
Autism
Bell's Palsy
Burning Feet or Hands
Carpal Tunnel Syndrome
Chemotherapy (reducing side effects)
Depression
Diabetes
Dysmenorrhea
Emotional Sensitivity
Energy (lack of)
Epilepsy
Fatigue
Hair (loss or thinning)
Hair Care (general)
Hangover
Hashimoto's Disease
Hiccups
Hot Flashes
Infertility
Inflammation
Insomnia
Irritability
Kidney Stones
Liver Detoxification
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Mood Swings
Morning Sickness
Nausea and Vomiting
Nerve Damage
Nervous Exhaustion
Nervousness
Neuralgia and Neuritis
Nightmares
Numbness
Obsessive Compulsive Disorder
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Rheumatoid Arthritis
Schizophrenia
Seborrhea
Seizures
Sleep (restless and disturbed)
Sore or Geographic Tongue
Stress
Thinking (cloudy)
Tics
TMJ
Tuberculosis
Twitching
Worry

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6
For the health condition: Stress

Table of Contents

Synopsis

Other ingredients used for Stress

Other health conditions supported by vitamin B6

Products containing vitamin B6

Health Concerns

Brands

Evidence supporting the use of: Vitamin B6For the health condition: Stress

Table of Contents

Synopsis

Other ingredients used for Stress

Other health conditions supported by vitamin B6

Products containing vitamin B6

Evidence supporting the use of: Vitamin B6
For the health condition: Stress