Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacinamide (vitamin B3) is scientifically supported as beneficial in wound healing and the treatment of certain sores, though most of the evidence comes from preclinical studies and a limited number of clinical trials. Niacinamide plays a key cellular role in energy metabolism and DNA repair, both of which are critical for tissue regeneration. Studies have shown that niacinamide can enhance keratinocyte (skin cell) proliferation and migration, leading to faster re-epithelialization of wounds. It also has anti-inflammatory properties and has been demonstrated to reduce the production of inflammatory cytokines, which is important in modulating the wound healing environment.

Topical niacinamide has been used in dermatology for its barrier-repairing effects, reducing transepidermal water loss and improving the skin’s resilience. Some small clinical studies and case reports suggest that niacinamide supplementation, either topical or oral, may improve healing rates of pressure ulcers and diabetic foot ulcers, though large, high-quality randomized controlled trials are still lacking.

Overall, while there is a plausible biological mechanism and some promising preliminary evidence, the use of niacinamide for wounds and sores is not yet universally adopted in clinical guidelines. Its use is best seen as adjunctive rather than primary therapy, and further research is needed to establish standardized protocols and efficacy.

More about niacinamide (vitamin B3)
More about Wounds and Sores

Other ingredients used for Wounds and Sores

Other health conditions supported by niacinamide (vitamin B3)

Products containing niacinamide (vitamin B3)

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