Digestzymes Designs for Health | Digestive Enzyme Guide

Name: Digestzymes™
Brand: Designs For Health
SKU: DH-DIG180
Price: 79.99 USD
Availability: InStock

Explore Digestzymes Designs for Health — a multi-enzyme blend with Betaine HCl, Ox bile, and DPPIV to support protein, fat, and carbohydrate digestion.

Product Overview

Digestzymes Designs for Health: Comprehensive Digestive Enzyme Support

Digestzymes™ from Designs for Health is a multi-enzyme digestive supplement formulated to support the optimal breakdown of proteins, fats, and carbohydrates.* The formula pairs a proprietary blend of digestive enzymes with Betaine hydrochloride (HCl) and Ox bile extract, creating a broad-spectrum approach to digestive support.

What sets Digestzymes Designs for Health apart is its inclusion of the specialized protease dipeptidyl peptidase IV (DPPIV), which supports the proper breakdown of gluteomorphin (from gluten) and casomorphin (from casein).* The formula also includes Lactase to help break down the dairy sugar lactose.*

The use of Digestzymes™ before meals may be helpful for individuals who experience gas and bloating after eating, occasional constipation, or a feeling of fullness after eating only a small quantity of food.* Each bottle provides 180 capsules for a generous supply.

How It Works

A Multi-Pronged Approach to Digestive Support

Digestzymes Designs for Health addresses digestion at multiple stages. Betaine HCl supports stomach acid levels that are necessary for activating Pepsin, the primary gastric protease that initiates protein digestion.* Together, Betaine HCl and Pepsin work to break down dietary proteins into smaller peptides that can be further processed in the small intestine.*

Ox bile extract provides bile acids — natural digestive surfactants that emulsify dietary fats into smaller droplets, dramatically increasing the surface area available for Lipase to act.* This emulsification process is also vital for the absorption of fat-soluble vitamins.* Ox bile is commonly included in digestive enzyme supplement formulations for precisely this reason.

In the small intestine, the formula's blend of amylases, Glucoamylase, Lipase, Lactase, and Invertase supports the breakdown of carbohydrates, fats, and sugars into absorbable nutrients.* The specialized DPPIV protease targets proline-rich peptides from gluten and casein that are otherwise resistant to standard pancreatic and gastric proteases.*

What's inside

Key ingredients

Betaine HCl — 200 mg

Betaine hydrochloride provides a source of hydrochloric acid to support protein digestion and nutrient absorption in the stomach.* Research has identified Betaine as an osmoprotectant in intestinal epithelial cells, and animal data suggest it may help maintain barrier integrity by supporting tight junction protein expression (occludin, claudin-1).* Betaine HCl serves as the acid component that activates Pepsin and supports the acidic environment necessary for optimal gastric function.*

Ox bile extract — 180 mg

Ox bile provides bile acids — potent digestive surfactants that emulsify dietary fats, dramatically increasing the surface area available for Lipase activity and enabling fat-soluble vitamin absorption.* Research supports its role in fat digestion, particularly in individuals with bile acid deficiency or those who have had their gallbladder removed.* As a clinically used component of multi-enzyme digestive preparations, Ox bile directly supplements the endogenous bile component of digestion.* The small intestine is the primary site of bile acid action, where bile acids form micelles in the duodenum and jejunum to enable Lipase-mediated hydrolysis and are then reabsorbed in the terminal ileum.*

Peptidase (DPPIV) — 180 mg

DPPIV (dipeptidyl peptidase IV) from Aspergillus oryzae is a serine exopeptidase that cleaves N-terminal X-Pro or X-Ala dipeptides from polypeptides.* It is specifically relevant for breaking down proline-rich gluten and casein peptides that are otherwise resistant to standard pancreatic and gastric proteases.* In combination with other proteases, DPPIV has been shown to successfully degrade dietary gluten in vitro.* DPPIV is naturally expressed on the brush border membrane of the small intestinal mucosa, and brush border membrane digestion experiments have directly demonstrated its role in hydrolyzing immunodominant gliadin peptides.* It is a standard ingredient in gluten-digest enzyme supplement formulations.*

Amylases — 180 mg

Amylase is a core pancreatic and salivary digestive enzyme that catalyzes the hydrolysis of starches and glycogen into simpler sugars such as maltose and glucose.* It is a primary active ingredient in pancreatic enzyme replacement therapy (PERT), the FDA-regulated standard of care for pancreatic exocrine insufficiency.* Clinical evidence consistently supports its role in carbohydrate digestion and reducing dyspeptic symptoms.* Pancreatic Amylase is secreted into the duodenum where it completes the bulk of dietary starch hydrolysis, and research suggests Amylase deficiency in exocrine pancreatic insufficiency leads to reversible villus atrophy that is restored with supplementation.*

Pepsin — 180 mg

Pepsin is the primary gastric protease, produced as pepsinogen by chief cells of the gastric mucosa and activated by hydrochloric acid.* It initiates protein digestion in the stomach by cleaving peptide bonds, producing smaller peptides that can be easily absorbed in the small intestine.* Supplemental Pepsin, often paired with hydrochloric acid as in this formula, is used to support protein digestion in those with low stomach acid (hypochlorhydria).* Without Pepsin-initiated pre-digestion, subsequent pancreatic protease activity and small intestinal amino acid absorption may be impaired.*

Glucoamylase — 180 mg

Glucoamylase (amyloglucosidase) is an exo-acting carbohydrase that cleaves glucose units from the non-reducing ends of starch and dextrins.* It complements Amylase activity by completing the final hydrolysis step of dietary starch to absorbable glucose.* Supplemental Glucoamylase, typically included in multi-enzyme blends, has been shown in clinical trials to support carbohydrate digestion and reduce associated GI symptoms.* As the maltase-Glucoamylase (MGAM) enzyme complex, it is physically embedded in the brush border membrane of the small intestinal epithelium.*

Lactase — 180 mg

Lactase (beta-galactosidase) is the enzyme that hydrolyzes lactose — the sugar in dairy — into glucose and galactose.* Supplemental Lactase is the established approach for lactose intolerance, one of the most common digestive enzyme deficiencies globally.* Multiple randomized controlled trials and systematic reviews confirm that Lactase enzyme supplements effectively reduce GI symptoms of lactose intolerance, including bloating, gas, and discomfort.* Lactase is physiologically located on the brush border of the small intestinal mucosa, and exogenous oral supplements function within the small intestinal lumen to replicate this hydrolysis.*

Invertase — 180 mg

Invertase (sucrase, β-fructofuranosidase) hydrolyzes sucrose into glucose and fructose, supporting digestion of table sugar and sucrose-containing foods.* It is a natural brush-border enzyme produced in the small intestine and is included in digestive enzyme supplements to support carbohydrate digestion.* Deficiency of this enzyme causes congenital sucrase-isomaltase deficiency, a recognized and clinically significant digestive disorder.* Invertase acts specifically in the small intestine, anchored to the brush-border membrane of enterocytes in the duodenum and jejunum.*

Lipase — 180 mg

Lipase is the primary digestive enzyme responsible for hydrolyzing dietary triglycerides into fatty acids and glycerol in the small intestine.* It is a principal component of FDA-regulated pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency, and deficiency leads to fat malabsorption (steatorrhea) and fat-soluble vitamin deficiencies.* Lipase works with bile from the liver to break down fat molecules so they can be absorbed and used by the body.* Evidence from multiple randomized controlled trials and a meta-analysis confirms its role in improving fat absorption.*

Medium chain triglycerides

Medium chain triglycerides (MCTs) are lipids composed of fatty acids with 6–12 carbon atoms that follow a fundamentally different absorption pathway than long-chain fats.* Research shows MCTs are hydrolyzed in the small intestine by gastric and pancreatic Lipase and absorbed directly into the portal circulation without requiring bile salt micellization or chylomicron formation.* This makes MCTs clinically useful in conditions that compromise the normal digestive pathway for fat, including those with impaired small intestinal absorptive capacity.*

Designs For Health

Digestzymes™

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Digestzymes™

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Who Benefits

Who May Benefit from Digestzymes™

Digestzymes Designs for Health is designed for adults looking for comprehensive digestive enzyme support. The formula may be particularly helpful for individuals who experience occasional gas and bloating after eating, a feeling of fullness after consuming only a small quantity of food, or occasional constipation.*

The inclusion of DPPIV makes this formula relevant for those seeking support for the proper breakdown of gluten and casein peptides.* The Lactase component supports those who have difficulty digesting the dairy sugar lactose.* And the Ox bile extract provides bile acids that are especially important for the digestion of fat and fat-soluble vitamins — making this formula potentially supportive for individuals dealing with malabsorption and maldigestion of fats.*

This product is non-GMO.

Directions

How to Take Digestzymes™

Take 1 capsule per day with a meal or as directed by your health-care practitioner.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What does Digestzymes Designs for Health do?

Digestzymes™ is comprised of a proprietary blend of digestive enzymes along with Betaine hydrochloride (HCl) to support the optimal digestion of proteins, fats, and carbohydrates.* It contains the special protease DPPIV, which supports the proper breakdown of gluteomorphin (from gluten) and casomorphin (from casein), as well as Lactase for dairy sugar digestion and Ox bile for fat and fat-soluble vitamin digestion.*

Why does Digestzymes™ include Ox bile?

Ox bile provides bile acids, which are key to the digestion of fat and fat-soluble vitamins.* Bile acids act as natural digestive surfactants that emulsify dietary fats into smaller droplets, increasing the surface area available for Lipase to break down fats. Ox bile digestive enzyme formulas can offer further support for malabsorption and maldigestion, including fats.*

How does the DPPIV enzyme in Digestzymes™ support gluten and casein digestion?

DPPIV (dipeptidyl peptidase IV) is a specialized protease that targets proline-rich peptides found in gluten and casein — peptides that are otherwise resistant to breakdown by standard pancreatic and gastric proteases.* Research confirms that DPPIV cleaves N-terminal X-Pro dipeptides from these proteins, and in vitro studies have demonstrated its ability to degrade dietary gluten peptides.* It supports the proper breakdown of gluteomorphin and casomorphin.*

How many capsules are in a bottle of Digestzymes™?

Each bottle contains 180 capsules. At the recommended serving size of 1 capsule per day with a meal, this provides a 180-day supply.

Is Digestzymes™ non-GMO?

Yes, Digestzymes™ is a non-GMO product.

Can Digestzymes™ help with occasional bloating after meals?

The use of Digestzymes™ before meals may be helpful for individuals who experience gas and bloating after eating, occasional constipation, or a feeling of fullness after eating only a small quantity of food.* The formula's combination of digestive enzymes, Betaine HCl, and Ox bile works to support the breakdown of proteins, fats, and carbohydrates.*

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