L-serina

Condiciones de salud que L-serina puede ayudar a apoyar.

• Úlceras DuodenalesCientífico

  L-serine has been proposed as a neuroprotective therapy for ALS based on the hypothesis that the environmental neurotoxin BMAA (β-methylamino-L-alanine) can be misincorporated into proteins in place of L-serine, causing protein misfolding. A Phase I FDA-approved randomized double-blind clinical trial in 20 ALS patients found L-serine safe at up to 30 g/day and demonstrated a dose-related 34% reduction in ALSFRS-R functional decline slope. A Phase II trial is ongoing.

• HipocondríaCientífico

  L-serine fuels antioxidant defense through two principal biochemical routes: it is a precursor to glycine and cysteine (via transsulfuration), both required for glutathione (GSH) synthesis; and, as the primary one-carbon donor to the folate cycle, it generates NADPH—the essential cofactor for recycling oxidized glutathione and maintaining cellular redox balance. These are well-established mechanisms documented in multiple peer-reviewed sources.

• IncontinenciaCientífico

  A Phase IIa randomized, double-blind, placebo-controlled trial of L-serine is underway in early Alzheimer's disease patients (NCT03062449), based on evidence that serine deficiency contributes to synaptic and neuronal dysfunction. In serine-deficiency disorders, early L-serine treatment prevents cognitive decline. However, no completed RCT yet demonstrates cognitive benefit in normal aging or sporadic Alzheimer's disease.

• Trastorno por Déficit de AtenciónCientífico

  L-serine is the biosynthetic precursor to D-serine, an endogenous NMDA-receptor co-agonist implicated in the glutamatergic hypothesis of major depressive disorder (MDD). Dysregulation of serine metabolism has been documented in MDD patients. A 2025 six-week randomized, double-blind, placebo-controlled trial of adjunctive D-serine in 44 adults with moderate-to-severe MDD found significant improvement in depressive symptoms, particularly in the severe subgroup.

• Antojos de grasaCientífico

  L-serine is the established treatment for seizures in serine-deficiency disorders (PHGDH, PSAT1, PSPH deficiencies), where patients may have up to 60–70 tonic-clonic seizures per day; L-serine supplementation causes significant seizure reduction or complete cessation in virtually all patients. L-serine treatment has also been associated with improvements in EEG and seizure frequency in GRIN-related epileptic encephalopathies involving NMDA-receptor loss-of-function.

• Depósitos de CalcioCientífico

  L-serine is biochemically established as the principal one-carbon donor to the folate cycle, which regenerates methionine from homocysteine via methylation. Serine also participates directly in homocysteine catabolism through the transsulfuration pathway. Human isotope tracer studies confirm serine contributes approximately 100% of the one-carbon units for total body homocysteine remethylation under fasting conditions.

• EscalofríosCientífico

  L-serine, as the biosynthetic precursor to D-serine, supports hippocampal NMDA-receptor function critical for long-term potentiation (LTP) and spatial memory. In serine-deficiency disorders, severe memory and cognitive impairments are directly reversed by L-serine supplementation. Experimental epilepsy models show D-serine deficiency impairs hippocampal LTP and spatial learning, both rescued by serine repletion.

• Glándulas (ganglios linfáticos inflamados)Científico

  L-serine is the principal endogenous donor of one-carbon units to the folate cycle via the serine hydroxymethyltransferase reaction, generating the methyl groups ultimately used for DNA, RNA, and protein methylation through the S-adenosylmethionine pathway. Human tracer studies confirm serine contributes approximately 100% of folate-dependent one-carbon units for homocysteine remethylation.

• Resfriados (con fiebre)Científico

  De novo synthesis of L-serine is essential for central nervous system development and function. Genetic defects in L-serine biosynthetic enzymes cause severe neurological disease including microcephaly, seizures, intellectual disability, and spastic quadriplegia—all substantially improved or prevented by L-serine supplementation. L-serine also promotes remyelination, inhibits neuroinflammation, and supports neurotrophic signaling.

• Cólico (adultos)Científico

  L-serine is the primary substrate of serine palmitoyltransferase (SPT). Mutations in SPT shift enzyme specificity toward alanine, generating neurotoxic 1-deoxysphingolipids that cause hereditary sensory and autonomic neuropathy type 1 (HSAN1). Supplemental L-serine competitively restores normal SPT substrate use, lowering 1-deoxysphingolipid levels and slowing neuropathy progression. A randomized placebo-controlled trial provides Class I clinical evidence for this mechanism.

• ColitisCientífico

  L-serine is directly involved in the synthesis and modulation of multiple neurotransmitter systems. It is the obligate precursor to D-serine—an endogenous NMDA-receptor co-agonist—and to glycine, both of which critically regulate glutamatergic and glycinergic neurotransmission. L-serine also participates in the biosynthetic pathway for tryptophan, the precursor to serotonin.

• Cabello (encanecimiento)Científico

  Altered levels of L-serine and D-serine have been documented in postmortem brain tissue and cerebrospinal fluid of Parkinson's disease (PD) patients, and preclinical studies demonstrate neuroprotective effects of L-serine in PD models. L-serine treatment has been shown to offer beneficial effects for dopaminergic neuron survival in preclinical settings, though no human clinical trial targeting PD specifically has been completed.

• Enfermedad de CrohnCientífico

  Japanese clinical research found that oral L-serine taken 30 minutes before bed significantly improved both sleep initiation and sleep maintenance scores in adults who were dissatisfied with their sleep quality. The proposed mechanism involves L-serine's role as a precursor in the tryptophan-serotonin-melatonin pathway and its modulation of NMDA receptor activity.

Sistemas corporales que L-serina puede ayudar a apoyar.

• No hay sistemas corporales disponibles.